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- de Weert, J. (author), Smedes, F. (author), Beeltje, H. (author), de Zwart, D. (author), Hamers, T. (author) article 2020
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Bolt, R.J. (author), Bruni, S. (author), Neto, A. (author), Gerini, G. (author), TNO Defensie en Veiligheid (author)This contribution describes the design and characterization of a very compact 8-element proximity fed cavity antenna array realized completely in PCB technology. The cavities are formed by the placement of a series of through pins (vias) along a rectangular outline. Micro-strip lines excite the structure, and slot coupling is used to feed the...conference paper 2008
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Leeman, W.R. (author), van den Berg, K.J. (author), Houben, G.F. (author), TNO Kwaliteit van Leven (author)The human risk assessment of feed contaminants has often been hampered by a lack of knowledge concerning their behaviour when consumed by livestock. To gain a better understanding of the transfer of contaminants from animal feed to animal products, a meta-analysis of public literature was made. Data concerning feed contaminant concentrations,...article 2007
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van der Denier Gon, H. (author), van het Bolscher, M. (author), Visschedijk, A. (author), Zandveld, P.Y.J. (author), TNO Bouw en Ondergrond (author)An emission inventory for persistent organic pollutants (POP) is made for the year 2000 based on submissions of emission data from the Parties to the Convention on LRTAP. The inventory covers the UNECE territory except Canada and the United States. For the countries, sources or compounds lacking in official submissions, default emission...article 2007
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Vreugdenhil, H.J.I. (author), Emmen, H.H. (author), Mulder, P.G.H. (author), Weisglas-Kuperus, N. (author), TNO Voeding (author)PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old children of the Rotterdam PCB-dioxin cohort,...article 2004
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Vreugdenhil, H.J.I. (author), Lanting, C.I. (author), Mulder, P.G.H. (author), Boersma, E.R. (author), Weisglas-Kuperus, N. (author), TNO Preventie en Gezondheid (author)Objective: Our purpose was to evaluate whether effects of exposure to environmental levels of PCBs and dioxins on development in the Dutch cohort persist until school age. Study design: In the Dutch PCB/dioxin study, cognitive and motor abilities were assessed with the McCarthy Scales of Children's Abilities in children at school age. During...article 2002
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Oomen, A.G. (author), Sips, A.J.A.M. (author), Groten, J.P. (author), Sijm, D.T.H.M. (author), Tolls, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Children can take up contaminated soil via hand-to-mouth behavior. The contaminants can be mobilized from the soil by digestive juices and thus become available for intestinal absorption (i.e. become bioaccessible). In the present study components of an in vitro digestion model were varied to study their effect on the mobilization of several...article 2000
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Dulfer, W.J. (author), Govers, H.A.J. (author), Groten, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Most of the accumulation of polychlorinated biphenyls (PCBs) over the food chain can be attributed to contaminant uptake from food. The effect of fatty acid absorption on net uptake and transport fluxes of a selection of 14 PCBs over the organismal gut epithelium has been determined in monolayers of the colon carcinoma cell line Caco-2 as a...article 1998
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Brussaard, J.H. (author), van Dokkum, W. (author), van der Paauw, C.G. (author), de Vos, R.H. (author), de Kort, W.L.A.M. (author), Löwik, M.R.H. (author), TNO Voeding (author)To assess the level of exposure to food contaminants (cadmium, lead, PCBs, DDT, hexachlorobenzene, nitrate and malathion) a total-diet study was carried out. A total of 226 food products were analysed individually; the concentration of contaminants in products not selected for analysis was estimated with the help of published data. The results...article 1996
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Koopman-Esseboom, C. (author), Weisglas-Kuperus, N. (author), de Ridder, M.A.J. (author), van der Paauw, C.G. (author), Tuinstra, L.G.M.T. (author), Sauer, P.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective. To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants. Design. Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposure of breastfed infants was...article 1996
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Morse, D.C. (author), Plug, A. (author), Wesseling, W. (author), van den Berg, K.J. (author), Brouwer, A. (author), TNO Voeding (author)Pregnant Wistar WU rats were exposed to 0, 5, and 25 mg of the commercial polychlorinated biphenyl (PCB) mixture Aroclor 1254 per kilogram of body weight on Days 10 to 16 of gestation. Pregnant rats were sacrificed on Gestation Day 20 to observe effects on fetal body and brain weights. Male and female offspring were sacrificed on Postnatal Days...article 1996
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TNO Nutrition and Food Research (author), Vethaak, A.D. (author), Jol, J.G. (author), Meijboom, A. (author), Eggens, M.L. (author), Rheinallt, T.A. (author), Wester, P.W. (author), van de Zande, T. (author), Bergman, A. (author), Dankers, N. (author), Ariese, F. (author), Baan, R.A. (author), Everts, J.M. (author), Opperhuizen, A. (author), Marquenie, J.M. (author)Chemicals/CAS: Metals; Polychlorinated Biphenyls; Water Pollutantsarticle 1996
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Dulfer, W.J. (author), Groten, J.P. (author), Govers, H.A.J. (author)Polychlorinated biphenyls (PCBs) dissolved in dietary fat are absorbed in the gastrointestinal tract by the enterocytes in combination with the fatty acid proceeding from the lipid hydrolysis in the gut lumen. The effect of fatty acid absorption on the uptake and transport of 14 PCBs in enterocytes was studied using monolayers of the human...article 1996
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Huisman, M. (author), Koopman-Esseboom, C. (author), Fidler, V. (author), Hadders-Algra, M. (author), van der Paauw, C.G. (author), Tuinstra, L.G.M.Th. (author), Weisglas-Kuperus, N. (author), Sauer, P.J.J. (author), Touwen, B.C.L. (author), Boersma, E.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Polychlorinated biphenyls (PCBs) and dioxins (polychlorinated dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs)) are widespread environmental contaminants which are neurotoxic in animals. Perinatal exposure to PCBs, PCDDs, and PCDFs occurs prenatally via the placenta and postnatally via breast milk. To investigate whether such an exposure...article 1995
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van den Berg, K.J. (author), van Raaij, J.A.G.M. (author), Bragt, P.C. (author), Notten, W.R.F. (author), Medisch Biologisch Laboratorium TNO (author)Previous results in experimental systems have suggested that hydroxylated PCBs may decrease thyroid hormone levels through associative interaction with transthyretin. In the present paper it was investigated whether this property was also shared by various industrial chemicals, mainly pesticides. In total, 65 compounds from 12 chemical groups...article 1991
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de Vos, R.H. (author), van Dokkum, W. (author), Olthof, P.D.A. (author), Quirijns, J.K. (author), Muys, T. (author), van der Poll, J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Over a period of 2 yr 126 different food items of a market basket of 16-18 yr old males were purchased every 2 months. The foodstuffs were prepared as for eating, and were combined in 12 commodity groups. Twelves samples of each food group were homogenized and analysed for 78 different chemicals, including pesticides, PCBs, bromine, heavy metals...article 1984
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Wade, D.R. (author), Lohman, P.H.M. (author), Mattern, I.E. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)A commercial sample of the tuberculostatic drug isoniazid (INH) was found to have a weak mutagenic activity towards Salmonella typhimurium strains TA100 and TA1535. The addition of a rat or mouse liver homogenate to the test system decreased the mutagenic effect of INH. Hydrazine, an impurity of the INH sample, was also weakly mutagenic in...article 1981
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Vink, G.J. (author), Davis, P.B. (author), Hooftman, R.N. (author), Mattern, I.E. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: aroclor, 12767-79-2; benzo[a]pyrene, 50-32-8; mesylic acid ethyl ester, 62-50-0; mesylic acid methyl ester, 66-27-3; triaziquone, 68-76-8article 1981
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- Cocchiarella, L. (author), Mattern, I.E. (author), van Kralingen, C.G. (author), Medisch Biologisch Laboratorium TNO (author) article 1980
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Mattern, I.E. (author), Greim, H. (author), Medisch Biologisch Laboratorium TNO (author)Bacterial systems for the screening of chemical substances for mutagenic potential are receiving widespread attention. Now that many laboratories have introduced these test systems and a large number of substances has been tested, discrepancies in the results have become apparent. To discuss this problem, a workshop was organized at Neuherberg ...article 1978