Searched for: subject:"Placenta"
(1 - 17 of 17)
document
Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)
Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...
article 2018
document
Zaura, E. (author), Nicu, E.A. (author), Krom, B.P. (author), Keijser, B.J. (author)
The oral microbiota survives daily physical and chemical perturbations from the intake of food and personal hygiene measures, resulting in a long-term stable microbiome. Biological properties that confer stability in the microbiome are important for the prevention of dysbiosis-a microbial shift toward a disease, e.g., periodontitis or caries....
article 2014
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Rosman, A.N. (author), Guijt, A. (author), Vlemmix, F. (author), Rijnders, M. (author), Mol, B.W.J. (author), Kok, M. (author)
Objective. External cephalic version (ECV) is a safe and effective intervention that can prevent breech delivery, thus reducing the need for cesarean delivery. It is recommended in national guidelines. These guidelines also mention contraindications for ECV, and thereby restrict the application of ECV. We assessed whether the formulation of...
article 2013
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de Ruiter, M.C. (author), Alkemade, F.E. (author), de Gittenberger - Groot, A.C. (author), Poelmann, R.E. (author), Havekes, L.M. (author), van Dijk, K.W. (author), TNO Kwaliteit van Leven (author)
In this review, we briefly summarize the possible signals crossing the placental barrier and discuss the molecular mechanisms of epigenetic programming in the developing fetus leading to increased athero-susceptibility of the vessel wall. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
article 2008
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Bansal, S. (author), Gaspari, M. (author), Raj, H.G. (author), Kumar, A. (author), Cuda, G. (author), Verheij, E. (author), Tyagi, Y.K. (author), Ponnan, P. (author), Rastogi, R.C. (author), Parmar, V.S. (author), TNO Kwaliteit van Leven (author)
Our earlier investigations identified acetoxy drug: protein transacetylase (TAase), a unique enzyme in the endoplasmic reticulum (ER) catalyzing the transfer of acetyl groups from polyphenolic acetates (PA) to certain functional proteins. Recently we have established the identity of TAase with ER protein calreticulin (CR) and subsequently...
article 2008
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Kalanda, B.F. (author), van Buuren, S. (author), Verhoeff, F.H. (author), Brabin, B.J. (author), TNO Kwaliteit van Leven (author)
Objective: To describe fetal growth centiles in relation to maternal malaria and HIV status, using cross sectional measurements at birth. Design: A cross sectional study of pregnant women and their babies. Data on maternal socioeconomic status and current pregnancy, including HIV status and newborn anthropometry, were collected. Malaria...
article 2005
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Kalanda, B.F. (author), van Buuren, S. (author), Verhoeff, F.H. (author), Brabin, B.J. (author), TNO Kwaliteit van Leven (author)
Introduction: Infant growth has not been studied in developing countries in relation to maternal factors related to malaria in pregnancy and maternal illiteracy. Objective: To describe growth patterns in infants with low and normal birthweight and determine maternal risk factors for infant undernutrition. Methods: Babies born in a rural district...
article 2005
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Waalkens-Berendsen, D.H. (author), Kuilman-Wahls, M.E.M. (author), Bär, A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone (NHDC) was examined in Wistar Crl:(WI)WU BR rats. NHDC was fed at dietary concentrations of 0, 1.25, 2.5 or 5 to groups of 28 mated female rats from day 0 to 21 of gestation. At Cesarean section 25, 22, 23, and 23 rats were found to be pregnant in the control, low-, mid-, and...
article 2004
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Waalkens-Berendsen, D.H. (author), Smits-Van Prooije, A.E. (author), Bär, A. (author), TNO Voeding (author)
In a standard embryotoxicity/teratogenicity study, α-cyclodextrin (α-CD) was administered to groups of sixteen, artificially inseminated New Zealand White rabbits at dietary concentrations of 0, 5, 10, or 20%. An additional group received a diet containing 20% lactose. Treatment started on day 0 of gestation and ended on day 29 when the animals...
article 2004
document
Richardus, J.H. (author), Graafmans, W.C. (author), Verloove-Vanhorick, S.P. (author), Mackenbach, J.P. (author), Masuy-Stroobant, G. (author), Alderdice, F. (author), Blondel, B. (author), Kaminski, M. (author), Leidinger, J. (author), Da Purificação Araújo, M. (author), Lopes De Oliveira, L.F. (author), Bergsjø, P. (author), Lloyd, D.J. (author), Bakketeig, L.S. (author), Bannon, E.M. (author), Borkent-Polet, M. (author), Davidson, L.L. (author), Defoort, P. (author), Leitão, A.E. (author), Langhoff-Roos, J. (author), Garcia, A.M. (author), Papantoniou, N.E. (author), Wennergren, M. (author), Aelvoet, W. (author), Bødker, B. (author), Lindmark, G. (author), Penney, G. (author), Macfarlane, A. (author), Rantakalli, P. (author), Hartikainen, A.L. (author), Gissler, M. (author), Bakoula, C. (author), Lekea, V. (author), van der Pal, K. (author), Amelink-Verburg, M. (author), Holt, J. (author), Rebagliato, M. (author), Bolumar, F. (author)
Objective: A European concerted action (the EuroNatal study) investigated the background of differences in perinatal mortality between countries of Europe. The study aimed to determine the contribution of differences in quality of care, by looking at differences in the presence of suboptimal factors in individual cases of perinatal death. Design...
article 2003
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Waalkens-Berendsen, D.H. (author), Smits-van Prooije, A.E. (author), Bär, A. (author)
In a standard embryotoxicity/teratogenicity study, γ-cyclodextrin (γ-CD) was administered to groups of 16, artificially inseminated New Zealand White rabbits at dietary concentrations of 0, 5, 10, or 20%. A comparison group received a diet containing 20% lactose. Treatment started on day 0 of gestation and ended on day 29 when the animals were...
article 1998
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Bank, R.A. (author), Beekman, B. (author), Tenni, R. (author), Tekoppele, J.M. (author), Gaubius Instituut TNO (author)
Measurement of the glycosylated hydroxylysines galactosyl- and glucosylgalactosylhydroxylysine (GH and GGH) in combination with other amino acids has been based on ion-exchange chromatography followed by reaction with ninhydrin. Here, a rapid and sensitive high-performance liquid chromatographic method with fluorimetric detection has been...
article 1997
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Barrett-Bergshoeff, M.M. (author), Moorman, F. (author), Bos, R. (author), Rijken, D.C. (author), Gaubius Instituut TNO (author)
To study the role of the mannose receptor in cellular uptake and degradation of tissue-type plasminogen activator (t-PA), a set of five monoclonal antibodies (Moab) was generated against the mannose receptor isolated from human placental tissue. All Moab specifically recognised the 175 kDa mannose receptor in a crude placenta extract, as shown...
article 1997
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Ploemen, J.P.H.T.M. (author), Wormhoudt, L.W. (author), Haenen, G.R.M.M. (author), Oudshoorn, M.J. (author), Commandeur, J.N.M. (author), Vermeulen, N.P.E. (author), de Waziers, I. (author), Beaune, P.H. (author), Watabe, T. (author), van Bladeren, P.J. (author)
Ethylene dibromide (1,2-dibromoethane, EDB) is metabolized by two routes: a conjugative route catalyzed by glutathione S-transferases (GST) and an oxidative route catalyzed by cytochrome P450 (P450). The GST route is associated with carcinogenicity. An approach is presented to use human purified GST and P450 enzymes to explore the importance of...
article 1997
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Rompelberg, C.J.M. (author), Ploemen, J.H.T.M. (author), Jespersen, S. (author), van der Greef, J. (author), Verhagen, H. (author), van Bladeren, P.J. (author), TNO Voeding (author)
The irreversible and reversible inhibition of glutathione S-transferases (GSTs) by eugenol was studied in rat, mouse and man. Using liver cytosol of human, rat and mouse, species differences were found in the rate of irreversible inhibition of GSTs by eugenol in the presence of the enzyme tyrosinase. Tyrosinase was used to oxidize eugenol. No...
article 1996
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Dirven, H.A.A.M. (author), Dictus, E.L.J.T. (author), Broeders, N.L.H.L. (author), van Ommen, B. (author), van Bladeren, P.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Nonenzymatic and glutathione S-transferase (GST) catalyzed glutathione (GSH) conjugation has been postulated as a mechanism by which alkylating cytostatic drugs can be inactivated intracellularly. In this study, we describe studies on the glutathione-dependent biotransformation of thiotepa (tris(1-aziridinyl)phosphine sulfide), a trifunctional...
article 1995
document
Gaubius Institute TNO, 2313 AD Leiden, Netherlands (author), Bosma, P.J. (author), van den Berg, E.A. (author), Kooistra, T. (author), Siemieniak, D.R. (author), Slightom, J.L. (author)
We have determined the nucleotide sequence of the human plasminogen activator inhibitor-1 (PAI-1) gene and significant stretches of DNA which extend into its 5'- and 3'-flanking DNA regions; a total sequence of 15,867 base pairs (bp) is presented. The sequenced 5'-flanking DNA (1,520 bp) contains the essential eukaryotic cis-type proximal...
article 1988
Searched for: subject:"Placenta"
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