Searched for: subject%3A%22Pilot%255C%2Bstudies%22
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Degraen, D. (author), Bruno Fruchard, B. (author), Smolders, F. (author), Potetsianakis, E. (author), Güngör, S. (author), Krüger, A. (author), Steimle, J. (author)
Effective haptic feedback in virtual reality (VR) is an essential element for creating convincing immersive experiences. To design such feedback, state-of-the-art VR setups provide APIs for programmatically generating controller vibration patterns. While tools for designing vibrotactile feedback keep evolving, they often require expert knowledge...
conference paper 2021
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Klein Velderman, M. (author), Pannebakker, F.D. (author), van Vliet, W. (author), Reijneveld, S.A. (author)
Objective: Parental divorce has strong impacts on children. Evidence-based programs to support young children after parental divorce are rare. The U.S.-developed Children of Divorce Intervention Program (CODIP) is one of these. CODIP’s effectiveness outside the U.S. setting is to be further replicated. This study aimed at cultural adaptation of...
article 2018
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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)
Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...
article 2018
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Ding, D. (author), Burger, F. (author), Brinkman, W.P. (author), Neerincx, M.A. (author)
A number of negotiation training systems have been developed to improve people’s performance in negotiation. They mainly focus on the skills development, and less on negotiation understanding and improving self-efficacy. We propose a virtual reality negotiation training system that exposes users to virtual cognitions during negotiation with...
conference paper 2017
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Deziel, N.C. (author), Nuckols, J.R. (author), Jones, R.R. (author), Graubard, B.I. (author), de Roos, A.J. (author), Pronk, A. (author), Gourley, C. (author), Colt, J.S. (author), Ward, M.H. (author)
Proximity to facilities emitting polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/F) has been associated with increased risk of non-Hodgkin lymphoma (NHL). There is limited information about whether proximity to industrial sources leads to indoor PCDD/F contamination of homes. We measured carpet dust concentrations (pg/g...
article 2017
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Kardinaal, A.F.M. (author), van Erk, M.J. (author), Dutman, A.E. (author), Stroeve, J.H.M. (author), van de Steeg, E. (author), Bijlsma, S. (author), Kooistra, T. (author), van Ommen, B. (author), Wopereis, S. (author)
Metabolism maintains homeostasis at chronic hypercaloric conditions, activating postprandial response mechanisms, which come at the cost of adaptation processes such as energy storage, eventually with negative health consequences. This study quantified the metabolic adaptation capacity by studying challenge response curves. After a high-fat...
article 2015
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van Lint, C.L. (author), van der Boog, P.J.M. (author), Wang, W. (author), Brinkman, W.P. (author), Rövekamp, T.J.M. (author), Neerincx, M.A. (author), Rabelink, T.J. (author), van Dijk, S. (author)
Background: After a kidney transplantation, patients have to visit the hospital often to monitor for early signs of graft rejection. Self-monitoring of creatinine in addition to blood pressure at home could alleviate the burden of frequent outpatient visits, but only if patients are willing to self-monitor and if they adhere to the self...
article 2015
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O’Cathain, A. (author), Hoddinott, P. (author), Lewin, S. (author), Thomas, K.J. (author), Young, B. (author), Adamson, J. (author), Jansen, J.F.M. (author), Mills, N. (author), Moore, G. (author), Donovan, J.L. (author)
Feasibility studies are increasingly undertaken in preparation for randomised controlled trials in order to explore uncertainties and enable trialists to optimise the intervention or the conduct of the trial. Qualitative research can be used to examine and address key uncertainties prior to a full trial. We present guidance that researchers,...
article 2015
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Mooij, M.G. (author), van Duijn, E. (author), Knibbe, C.A.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Vaes, W.H.J. (author), Spaans, E. (author), Fabriek, B.O. (author), Sandman, H. (author), Grossouw, D. (author), Hanff, L.M. (author), Janssen, P.J.J.M. (author), Koch, B.C.P. (author), Tibboel, D. (author), de Wildt, S.N. (author)
Results: Ten infants (aged 0.1–83.1 months) were included; one was excluded as he vomited shortly after administration. In nine patients, [14C]AAP and metabolites in blood samples were detectable at expected concentrations: median (range) maximum concentration (Cmax) [14C]AAP 1.68 (0.75–4.76) ng/L, [14C]AAP-Glu 0.88 (0.34–1.55) ng/L, and [14C...
article 2014
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Dumay, A.C.M. (author), Haaker, T.I. (author), TNO Kwaliteit van Leven (author)
Background: A locum practitioner is an out-of-hours general practitioner who needs access to the electronic health record of visiting patients. The electronic locum record is a summary of the electronic health record available to the locum practitioner and includes the most significant health problems, the most recent records of the patient's...
article 2010
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Lubelli, B.A. (author), Nijland, T.G. (author), van Hees, R.P.J. (author), Hacquebord, A. (author), TNO Bouw en Ondergrond (author)
Salt crystallization is a common cause of damage to porous building materials. Recent research has shown that some chemical compounds may inhibit salt crystallization or alter the mode of crystallization, thus limiting salt damage development, provided that the inhibitor was introduced prior to salt crystallization. In this paper, a pilot study...
article 2010
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van de Ven, P. (author), Fransman, W. (author), Schinkel, J. (author), Rubingh, C. (author), Warren, N. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
The web-based tool "Stoffenmanager" was initially developed to assist small- and medium-sized enterprises in the Netherlands to make qualitative risk assessments and to provide advice on control at the workplace. The tool uses a mechanistic model to arrive at a "Stoffenmanager score" for exposure. In a recent study it was shown that variability...
article 2010
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van Peppen, R.P.S. (author), Schuurmans, M.J. (author), Stutterheim, E.C. (author), Lindeman, E. (author), van Meeteren, N.L.U. (author), TNO Kwaliteit van Leven (author)
Objective: To determine the influence of tutor expertise on the uptake of a physiotherapists' educational programme intended to promote the use of outcome measures in the management of patients with stroke. Design: Pilot randomized controlled trial. Methods: Thirty physiotherapists involved in stroke management were randomized into two groups...
article 2009
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Smit, M.G.D. (author), Bechmann, R.K. (author), Hendriks, A.J. (author), Skadsheim, A. (author), Larsen, B.K. (author), Baussant, T. (author), Bamber, S. (author), Sannei, S. (author), TNO Industrie en Techniek (author)
Biomarkers are widely used to measure environmental impacts on marine species. For many biomarkers, it is not clear how the signal levels relate to effects on the whole organism. This paper shows how species sensitivity distributions (SSDs) can be applied to evaluate multiple biomarker responses in species assemblages. To our knowledge, the...
article 2009
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Doornebosch, A.J. (author), Cools, H.J.M. (author), Slee-Turkenburg, M.E.C. (author), van Elk, M.G. (author), Schoone-Harmsen, M. (author), TNO Industrie en Techniek TNO Kwaliteit van Leven (author)
Although scientific evidence shows that therapy improves movement recovery following a stroke, the duration of the reimbursed therapy available to patients is decreasing. To compensate for the reduction in personal therapy self-training procedures using robotic arms have been developed for hemiplegic patients. In this Dutch pilot study, the...
article 2007
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van Geer, F. (author), Marsman, A. (author), Janssen, G.M.C.M. (author), TNO Bouw en Ondergrond (author)
Usually the design of the monitoring system is based on the relation between the monitoring effort and the uncertainty of the information. Often the estimation error standard deviation is used as a criterion for the design. Despite the fact that, for scientists, the standard deviation as a measure of uncertainty is a logical criterion, water...
conference paper 2007
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Robitail, S. (author), Simeoni, M.-C. (author), Erhart, M. (author), Ravens-Sieberer, U. (author), Bruil, J. (author), Auquier, P. (author), TNO Preventie en Gezondheid (author)
Purpose: The KIDSCREEN project aims to develop a European cross-cultural generic self-administered Health-Related Quality of Life (HRQoL) instrument for children and adolescents. Proxy measures HRQoL should be a useful and practical alternative to assess children's HRQoL. The KIDSCREEN pilot study involved 3988 children and 2526 child-proxy...
article 2006
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Ravens-Sieberer, U. (author), Gosch, A. (author), Rajmil, L. (author), Erhart, M. (author), Bruil, J. (author), Duer, W. (author), Auquier, P. (author), Power, M. (author), Abel, T. (author), Czemy, L. (author), Mazur, J. (author), Czimbalmos, A. (author), Tountas, Y. (author), Hagquist, C. (author), Kilroe, J. (author), Fuerth, K. (author), Auquier, P. (author), Robitail, S. (author), Simeoni, M.C. (author), Orbicini, D. (author), von Rueden, U. (author), Dimitrakaki, C. (author), Detmar, S. (author), Verips, E. (author), Mierzejewska, E. (author), Berra, S. (author), Tebé, C. (author), Bisegger, C. (author), Cloetta, B. (author), Atherton, C. (author), TNO Preventie en Gezondheid (author)
This study describes the development and reports the first psychometric results of the European KIDSCREEN-52 generic health-related quality-of-life questionnaire for children and adolescents. The KIDSCREEN-52, including ten dimensions, was applied in a European survey involving 12 countries (i.e., Austria, Switzerland, Czech Republic, Germany,...
article 2005
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van Helden, H.H.P.M. (author), Vanwersch, R.A.P. (author), Kuijpers, W.C. (author), Trap, H.C. (author), Philippens, I.H.C. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
The main purpose of this pilot study was to estimate the lowest observable adverse effect level (LOAEL) for the electroencephalogram (EEG) upon long-term, low-level exposure of vehicle-pretreated and pyridostigmine-pretreated marmoset monkeys to sarin vapour. This is the C·t value (t = 5 h) of exposure at which the EEG becomes significantly...
article 2004
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van Helden, H.P.M. (author), Trap, H.C. (author), Kuijpers, W.C. (author), Oostdijk, J.P. (author), Benschop, H.P. (author), Langenberg, J.P. (author), Prins Maurits Laboratorium TNO (author)
The purpose of this pilot study was to indicate, for low-level exposure of conscious guinea pigs and marmoset monkeys to sarin vapour in air, the lowest-observable-adverse-effect level (LOAEL) of sarin for miosis. This is the concentration × time (C·t) value (t = 5 h) of exposure at which miosis becomes significant. The ratio of pupil and iris...
article 2004
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