Searched for: subject:"Physiological%5C+Sciences"
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Hulsman, M. (author), Mentink, A. (author), van Someren, E.P. (author), Dechering, K.J. (author), de Boer, J. (author), Reinders, M.J.T. (author), TNO Kwaliteit van Leven (author)
Background: Oligonucleotide arrays have become one of the most widely used high-throughput tools in biology. Due to their sensitivity to experimental conditions, normalization is a crucial step when comparing measurements from these arrays. Normalization is, however, far from a solved problem. Frequently, we encounter datasets with significant...
article 2010
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van Cruchten, S.T.J. (author), de Waart, D.R. (author), Kunne, C. (author), Hooiveld, G.J.E.J. (author), Boekschoten, M.V. (author), Katan, M.B. (author), Oude Elferink, R.P.J. (author), Witkamp, R.F. (author), TNO Kwaliteit van Leven (author)
Cafestol is a diterpene present in unfiltered coffees. It is the most potent cholesterol-elevating compound present in the human diet. However, the precise mechanisms underlying this effect are still unclear. In contrast, cafestol is also known as a hepatoprotective compound, which is likely to be related to the induction of glutathione...
article 2010
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Pham, T.M. (author), Hagman, B. (author), Codita, A. (author), van Loo, P.L.P. (author), Strömmer, L. (author), Baumans, V. (author), TNO Kwaliteit van Leven (author)
The impact of invasive experimental procedures on perceived stress and pain may be dependent on both physical and social environmental conditions. The aim of this study was to evaluate the effects of a physically and a socially enriched environment on the need for pain relief following painful experimental procedures. A non-invasive method to...
article 2010
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Huber, M. (author), van de Vijver, L.P.L. (author), Parmentier, H. (author), Savelkoul, H. (author), Coulier, L. (author), Wopereis, S. (author), Verheij, E. (author), van der Greef, J. (author), Nierop, D. (author), Hoogenboom, R.A.P. (author), TNO Kwaliteit van Leven (author)
Consumers expect organic products to be healthier. However, limited research has been performed to study the effect of organic food on health. The present study aimed to identify biomarkers of health to enable future studies in human subjects. A feeding experiment was performed in two generations of three groups of chickens differing in immune...
article 2010
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Smilde, A.K. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Bijlsma, S. (author), Rubingh, C.M. (author), Vis, D.J. (author), Jellema, R.H. (author), Pijl, H. (author), Roelfsema, F. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
In metabolomics, time-resolved, dynamic or temporal data is more and more collected. The number of methods to analyze such data, however, is very limited and in most cases the dynamic nature of the data is not even taken into account. This paper reviews current methods in use for analyzing dynamic metabolomic data. Moreover, some methods from...
article 2010
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van de Pas, N.C.A. (author), Soffers, A.E.M.F. (author), Freidig, A.P. (author), van Ommen, B. (author), Woutersen, R.A. (author), Rietjens, I.M.C.M. (author), de Graaf, A.A. (author), TNO Kwaliteit van Leven (author)
Elevated plasma cholesterol, a well-known risk factor for cardiovascular diseases, is the result of the activity of many genes and their encoded proteins in a complex physiological network. We aim to develop a minimal kinetic computational model for predicting plasma cholesterol levels. To define the scope of this model, it is essential to...
article 2010
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van Erk, M.J. (author), Wopereis, S. (author), Rubingh, C. (author), van Vliet, T. (author), Verheij, E. (author), Cnubben, N.H. (author), Pedersen, T.L. (author), Newman, J.W. (author), Smilde, A.K. (author), Greef, J.V.D. (author), Hendriks, H.F. (author), van Ommen, B. (author), TNO Kwaliteit van Leven (author)
Background. Chronic systemic low-grade inflammation in obese subjects is associated with health complications including cardiovascular diseases, insulin resistance and diabetes. Reducing inflammatory responses may reduce these risks. However, available markers of inflammatory status inadequately describe the complexity of metabolic responses to...
article 2010
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van Ommen, B. (author), El-Sohemy, A. (author), Hesketh, J. (author), Kaput, J. (author), Fenech, M. (author), Evelo, C.T. (author), McArdle, H.J. (author), Bouwman, J. (author), Lietz, G. (author), Mathers, J.C. (author), Fairweather-Tait, S. (author), van Kranen, H. (author), Elliott, R. (author), Wopereis, S. (author), Ferguson, L.R. (author), Méplan, C. (author), Perozzi, G. (author), Allen, L. (author), Rivero, D. (author), TNO Kwaliteit van Leven (author)
Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, for maintaining good health. With advances in systems biology and genomics technologies, it is becoming feasible to assess the activity of...
article 2010
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de Graaf, A.A. (author), Maathuis, A. (author), de Waard, P. (author), Deutz, N.E.P. (author), Dijkema, C. (author), de Vos, W.M. (author), Venema, K. (author), TNO Kwaliteit van Leven (author)
This study introduces a stable-isotope metabolic approach employing [U-13C]glucose that, as a novelty, allows selective profiling of the human intestinal microbial metabolic products of carbohydrate food components, as well as the measurement of the kinetics of their formation pathways, in a single experiment. A well-established, validated in...
article 2010
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Bakker, G.C.M. (author), van Erk, M.J. (author), Pellis, L. (author), Wopereis, S. (author), Rubingh, C.M. (author), Cnubben, N.H.P. (author), Kooistra, T. (author), van Ommen, B. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Background: Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Objective: It was hypothesized that specific dietary components are able to reduce low-grade inflammation as well as metabolic and oxidative stress. Design: Dietary products [resveratrol, green tea extract, α-tocopherol,...
article 2010
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Joosten, M.M. (author), TNO Kwaliteit van Leven (author), KvL (author)
doctoral thesis 2010
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Draisma, H.H.M. (author), Reijmers, T.H. (author), van Kloet, F.D. (author), Bobeldijk-Pastorova, I. (author), Spies-Faber, E. (author), Vogels, J.T.W.E. (author), Meulman, J.J. (author), Boomsma, D.I. (author), van Greef, J.D. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Combination of data sets from different objects (for example, from two groups of healthy volunteers from the same population) that were measured on a common set of variables (for example, metabolites or peptides) is desirable for statistical analysis in "omics" studies because it increases power. However, this type of combination is not directly...
article 2010
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Mateo Anson, N. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author), TNO Kwaliteit van Leven (author)
Wholegrain consumption is associated with several health benefits, in contrast to the consumption of refined grains. This can partly be related to the antioxidant compounds in the outer parts of the grain kernel. The bioaccessibility of these antioxidant compounds from the wholegrain matrix during gastrointestinal digestion is crucial for their...
article 2010
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Vis, D.J. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Pijl, H. (author), Roelfsema, F. (author), van der Greef, J. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)
The detection of hormone secretion episodes is important for understanding normal and abnormal endocrine functioning, but pulse identification from hormones measured with short interval sampling is challenging. Furthermore, to obtain useable results, the model underlying hormone secretion and clearance must be augmented with restrictions based...
article 2010
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Kaput, J. (author), Evelo, C.T. (author), Perozzi, G. (author), van Ommen, B. (author), Cotton, R. (author), TNO Kwaliteit van Leven (author)
Nutrigenomics is the science of analyzing and understanding gene-nutrient interactions, which because of the genetic heterogeneity, varying degrees of interaction among gene products, and the environmental diversity is a complex science. Although much knowledge of human diversity has been accumulated, estimates suggest that ~90% of genetic...
article 2010
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Baumans, V. (author), van Loo, P.L.P. (author), Pham, T.M. (author), TNO Kwaliteit van Leven (author)
Rats and mice are the most commonly used species as laboratory animal models of diseases in biomedical research. Environmental factors such as cage size, number of cage mates and cage structure such as environmental enrichment can affect the physiology and behavioural development of laboratory animals and their well-being throughout their lives....
article 2010
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Werkman, A. (author), Hulshof, P.J. (author), Stafleu, A. (author), Kremers, S.P. (author), Kok, F.J. (author), Schouten, E.G. (author), Schuit, A.J. (author), TNO Kwaliteit van Leven (author)
Background. The increased prevalence of overweight and obesity warrants preventive actions, particularly among people in transitional stages associated with lifestyle changes, such as occupational retirement. The purpose is to investigate the effect of a one year low-intensity computer-tailored energy balance programme among recent retirees on...
article 2010
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Hogenkamp, P.S. (author), Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)
Background: An important question in the regulation of energy intake is whether dietary learning of energy content depends on the food's characteristics, such as texture. Texture might affect the duration of sensory exposure and eating rate. Objective: The objective was to investigate whether a long sensory exposure, due to differences in means...
article 2010
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Gubbels, J.S. (author), Kremers, S.P.J. (author), Stafleu, A. (author), Dagnelie, P.C. (author), de Vries, N.K. (author), Thijs, C. (author), TNO Kwaliteit van Leven (author)
Background: Previous research has shown that children in child-care do not comply with dietary intake recommendations (i.e. either exceeding or not meeting recommendations), which may be attributable to specific features of the child-care environment. The present study explored the relationship between the social and physical child-care (day...
article 2010
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Pfuhler, S. (author), Kirkland, D. (author), Kasper, P. (author), Hayashi, M. (author), Vanparys, P. (author), Carmichael, P. (author), Dertinger, S. (author), Eastmond, D. (author), Elhajouji, A. (author), Krul, C.A.M. (author), Rothfuss, A. (author), Schoening, G. (author), Smith, A. (author), Speit, G. (author), Thomas, C. (author), van Benthem, J. (author), Corvi, R. (author), TNO Kwaliteit van Leven (author)
In vivo genetic toxicology tests measure direct DNA damage or the formation of gene or chromosomal mutations, and are used to predict the mutagenic and carcinogenic potential of compounds for regulatory purposes and/or to follow-up positive results from in vitro testing. These tests are widely used and consume large numbers of animals, with a...
article 2009
Searched for: subject:"Physiological%5C+Sciences"
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