N-Type self-assembled monolayer field-effect transistors and complementary inverters

This work describes n-type self-assembled monolayer field-effect transistors (SAMFETs) based on a perylene derivative which is covalently fixed to an aluminum oxide dielectric via a phosphonic acid linker. N-type SAMFETs spontaneously formed by a single layer of active molecules are demonstrated for transistor channel length up to 100 μm. Highly...

Environmental risk assessment of phosphonates, used in domestic laundry and cleaning agents in the Netherlands

In the long-term cooperative project Voluntary Plan of Action (1990) between the Dutch Soap and Detergent Association (NVZ) and the Dutch Ministry of Housing, Spatial Planning and the Environment (VROM) environmental risk assessments of several main components of laundry cleaning formulations were completed. As a part of that project the...

Determination of alkylphosphonic acids by microcolumn liquid chromatography with gradient elution coupled on-line with flame photometric detection

Microcolumn liquid chromatography with gradient elution and on-line flame photometric detection has been used for the selective and rapid determination of non-volatile alkylphosphonic acids, which are hydrolysis products of nerve agents, in aqueous samples. A make-up of water was used to maintain stable introduction of the eluent during a...

Identification of the C3H7 moiety of isopropyl- and propylphosphonates by electrospray tandem mass spectrometry

Structure analysis of phosphorus compounds within the framework of the Chemical Weapons Convention requires the specific identification of alkyl substituents on phosphorus. In this work the distinction of the P-propyl substituent in propylphosphonic acid derivatives by electrospray tandem mass spectrometry was investigated. P-Isopropyl and P-n...

Synthesis of pyrophosphonic acid analogues of farnesyl pyrophosphate

The synthesis of four new analogues (i.e. 3-6) of farnesyl pyrophosphate (FPP), which may function as inhibitor of squalene synthase, is described. Compounds 3 and 4 were readily accessible by reaction of farnesal with diethyl phosphite or dimethyl lithiomethylphosphonate, respectively, followed by condensation of the resulting alcohols with...

The binding of sarin in the blood plasma of the rat

Sephadex filtration of serum from rats 10 min after injection of 50 μg/kg of 32P-sarin demonstrated that about 70 per cent of the radioactivity present in the serum was attached to molecules with a molecular weight above 10,000. Incubation of samples of this serum with oximes caused a decrease in the amounts of 32P attached to the large...

The influence of triorthocresylphosphate on the distribution of 32P in the body of the rat after the injection of 32P-sarin

The ChE- and AE- activities and the 32P-concentration of the plasma from rats 1 and 24 hr after s.c. injection of 32P-sarin (200 μg kg) were measured. One hr after the injection the ChE was inhibited to approx. 10 per cent and the AE to 40-50 per cent; 23 hr later 50 per cent of the ChE activity was found to be restored and the AE had recovered...