Searched for: subject%3A%22Phenylalanine%22
(1 - 20 of 26)

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Anjema, K. (author), van Rijn, M. (author), Verkerk, P.H. (author), Burgerhof, J.G.M. (author), Heiner-Fokkema, M.R. (author), van Spronsen, F.J. (author)
In phenylketonuria, knowledge about the relation between behavior and plasma phenylalanine is scarce. The aim of this study was to determine whether high phenylalanine is associated with disturbed behavior noticed by the patient and or close environment (parents or partners). 48 early treated PKU patients (median age 8.5, range 0-35. years)...
article 2011
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Molhoek, E.M. (author), van Dijk, A. (author), Veldhuizen, E.J.A. (author), Haagsman, H.P. (author), Bikker, F.J. (author)
A truncated version of host defense peptide chicken cathelicidin-2, C1-15, possesses potent, broad spectrum antibacterial activity. A variant of this peptide, F2,5,12W, which contains 3 phenylalanine to tryptophan substitutions, possesses improved antibacterial activity and lipopolysaccharide (LPS) neutralizing activity compared to C1-15. In...
article 2011
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van Spronsen, F.J. (author), Rijn, M. (author), Dorgelo, B. (author), Hoeksma, M. (author), Bosch, A.M. (author), Mulder, M.F. (author), de Klerk, J.B.C. (author), de Koning, T. (author), Rubio-Gozalbo, M.E. (author), de Vries, M. (author), Verkerk, P.H. (author)
Background: The clinical severity of phenylalanine hydroxylase deficiency is usually defined by either pre-treatment phenylalanine (Phe) concentration or Phe tolerance at 5 years of age. So far, little is known about the course of Phe tolerance or the ability of both pre-treatment Phe and Phe tolerance at early age to predict Phe tolerance at...
article 2009
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TNO Kwaliteit van Leven (author), Verhoef, S. (author), Wierckx, N. (author), Westerhof, R.G.M. (author), Winde, J.H.de (author), Ruijssenaars, H.J. (author)
Two solvent-tolerant Pseudomonas putida S12 strains, originally designed for phenol and p-coumarate production, were engineered for efficient production of p-hydroxystyrene from glucose. This was established by introduction of the genes pal and pdc encoding L-phenylalanine/L-tyrosine ammonia lyase and p-coumaric acid decarboxylase, respectively....
article 2009
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TNO Kwaliteit van Leven (author), Hageman, J.A. (author), Hendriks, M.M.W.B. (author), Westerhuis, J.A. (author), van der Werf, M.J. (author), Berger, R. (author), Smilde, A.K. (author)
One of the new expanding areas in functional genomics is metabolomics: measuring the metabolome of an organism. Data being generated in metabolomics studies are very diverse in nature depending on the design underlying the experiment. Traditionally, variation in measurements is conceptually broken down in systematic variation and noise where the...
article 2008
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Tchetverikov, I. (author), Kraan, M.C. (author), van El, B. (author), Hanemaaijer, R. (author), de Groot, J. (author), Huizinga, T.W.J. (author)
Objective: To analyse the effects of leflunomide and methotrexate treatment on matrix metalloproteinase (MMP) activity levels in a2 macroglobulin/MMP (α2M/MMP) complexes in the systemic circulation of rheumatoid arthritis (RA) patients. Methods: A total of 102 RA patients from a prospective, double-blind, randomised clinical trial comparing...
article 2008
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Nijkamp, K. (author), Westerhof, R.G.M. (author), Ballerstedt, H. (author), de Bont, J.A.M. (author), Wery, J. (author), TNO Kwaliteit van Leven (author)
A Pseudomonas putida S12 strain was constructed that is able to convert glucose to p-coumarate via the central metabolite l-tyrosine. Efficient production was hampered by product degradation, limited cellular L-tyrosine availability, and formation of the by-product cinnamate via L-phenylalanine. The production host was optimized by inactivation...
article 2007
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Verhoef, S. (author), Ruijssenaars, H.J. (author), de Bont, J.A.M. (author), Wery, J. (author), TNO Kwaliteit van Leven (author)
Pseudomonas putida strain S12palB1 was constructed that produces p-hydroxybenzoate from renewable carbon sources via the central metabolite l-tyrosine. P. putida S12palB1 was based on the platform strain P. putida S12TPL3, which has an optimised carbon flux towards l-tyrosine. Phenylalanine ammonia lyase (Pal) was introduced for the conversion...
article 2007
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Hoeksma, M. (author), van Rijn, M. (author), Verkerk, P.H. (author), Bosch, A.M. (author), Mulder, M.F. (author), de Klerk, J.B.C. (author), de Koning, T.J. (author), Rubio-Gozalbo, E. (author), de Vries, M. (author), Sauer, P.J.J. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)
In a previous study, Dutch children with phenylketonuria (PKU) were found to be slightly shorter than their healthy counterparts. In the literature, it has been hypothesized that a higher protein intake is necessary to optimize growth in PKU patients. The study aimed to investigate whether protein intake (total, natural and protein substitute)...
article 2005
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Crone, M.R. (author), Spronsen, F.J. (author), Oudshoorn, K. (author), Bekhof, J. (author), van Rijn, G. (author), Verkerk, P.H. (author), TNO Preventie en Gezondheid (author)
Background. The objective of this study was to determine the importance of parental factors possibly related to dietary control in early and continuously treated patients with phenylketonuria (PKU). Methods. A questionnaire was disseminated among parents of 238 patients with PKU born after the nationwide introduction of newborn screening for PKU...
article 2005
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Nijkamp, K. (author), van Luijk, N. (author), de Bont, J.A.M. (author), Wery, J. (author), TNO Kwaliteit van Leven TNO Voeding (author)
A Pseudomonas putida S12 strain was constructed that efficiently produced thefine chemical cinnamic acid from glucose or glycerol via the central metabolite phenylalanine. The gene encoding phenylalanine ammonia lyase from the yeast Rhodosporidium toruloides was introduced. Phenylalanine availability was the main bottleneck in cinnamic acid...
article 2005
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TNO Kwaliteit van Leven (author), Kypreos, K.E. (author), van Dijk, K.W. (author), Havekes, L.M. (author), Zannis, V.I. (author)
To identify the residues in the carboxyl-terminal region 260-299 of human apolipoprotein E (apoE) that contribute to hypertriglyceridemia, two sets of conserved, hydrophobic amino acids between residues 261 and 283 were mutated to alanines, and recombinant adenoviruses expressing these apoE mutants were generated. Adenovirus-mediated gene...
article 2005
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Brink, E.J. (author), Boelsma, E. (author), Steijns, J. (author), Hendriks, H.F.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The aim of the study was to investigate the bioavailability of tryptophan (Trp) from a Trp-enriched peptide mixture in healthy men. A second objective was to investigate the effect of this Trp-enriched protein hydrolysate on potential parameters of serotonergic activity. serum serotonim melatonin and prolactin and urinary 5-hydroxyindol-acetic...
article 2004
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Klaasse, E. (author), de Ligt, R.A.F. (author), Roerink, S.F. (author), Lorenzen, A. (author), Milligan, G. (author), Leurs, R. (author), IJzerman, A.P. (author), TNO Voeding (author)
We studied fusion proteins between the human adenosine A1 receptor and different 351Cys-mutated Gi1 α-subunits (A1-Giα) with respect to two important concepts in receptor pharmacology, i.e. allosteric modulation and constitutive activity/inverse agonism. The aim of our study was twofold. We first analysed whether such fusion products are still...
article 2004
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Collen, A. (author), Hanemaaijer, R. (author), Lupu, F. (author), Quax, P.H.A. (author), van Lent, N. (author), Grimbergen, J. (author), Peters, E. (author), Koolwijk, P. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Adult angiogenesis, associated with pathologic conditions, is often accompanied by the formation of a fibrinous exudate. This temporary matrix consists mainly of fibrin but is intermingled with plasma proteins and collagen fibers. The formation of capillary structures in a fibrinous matrix in vivo was mimicked by an in vitro model, in which...
article 2003
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TNO Kwaliteit van Leven (author), Huijbregts, S.C.J. (author), van Spronsen, F.J. (author), Licht, R. (author), de Sonneville, L.M.J. (author), Berends, I.E. (author), Verkerk, P.H. (author), Sergeant, J.A. (author)
This study examined motor control in 61 early and continuously treated patients with phenylketonuria (PKU) and 69 control participants, aged 7 to 14 years. The pursuit task demanded concurrent planning and execution of unpredictable movements, whereas the tracking task required a highly automated circular movement that could be planned in...
article 2003
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Noort, D. (author), Hulst, A.G. (author), Jansen, R. (author), Prins Maurits Laboratorium TNO (author)
Covalent binding of various clinically important nitrogen mustards to the cysteine-34 residue of human serum albumin, in vitro and in vivo, is demonstrated. A rapid method for detection of these adducts is presented, based on liquid chromatography-tandem mass spectrometry analysis of the adducted tripeptide Cys*-Pro-Phe after digestion of the...
article 2002
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Huijbregts, S.C.J. (author), de Sonneville, L.M.J. (author), Licht, R. (author), van Spronsen, F.J. (author), Verkerk, P.H. (author), Sergeant, J.A. (author)
Fifty-seven 7-14-year-old early- and continuously treated phenylketonuria (PKU) patients and 65 matched controls performed a sustained attention task. PKU patients with plasma phenylalanine (phe) levels higher than 360 μmol/l at the time of testing exhibited, compared to controls, lower speed of information processing, a lower ability to inhibit...
article 2002
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Koolwijk, P. (author), Sidenius, N. (author), Peters, E. (author), Sier, C.F.M. (author), Hanemaaijer, R. (author), Blasi, F. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Pericellular proteolysis plays an important role in cell migration and the formation of new capillary structures. The plasminogen activator/plasmin and matrix degrading metalloproteinase (MMP) cascades act together in the remodeling of matrix and cell-matrix contacts. Previously we have shown that the formation of capillary structures by human...
article 2001
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Stemerdink, B.A. (author), Kalverboer, A.F. (author), van der Meere, J.J. (author), van der Molen, M.W. (author), Huisman, J. (author), de Jong, L.W.A. (author), Slijper, F.M.E. (author), Verkerk, P.H. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)
Thirty patients with early and continuously treated phenylketonuria (PKU) between 8 and 20 years of age were compared with 30 controls, matched individually for age, sex, and educational level of both parents, on behaviour rating scales for parents and teachers as well as a school achievement scale. PKU patients, as a group, demonstrated more...
article 2000
Searched for: subject%3A%22Phenylalanine%22
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