Searched for: subject:"Phenol"
(1 - 20 of 46)

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Bosilj, M. (author), Rustam, L. (author), Thomann, R. (author), Melke, J. (author), Fischer, A. (author), White, R.J. (author)
Selective hydrogenations in the aqueous phase are an important transformation in the context of developing biorefinery concepts. In this report the application and optimisation of nitrogen-doped carbon (NDC) supported Pd nanoparticles as hydrogenation catalysts is discussed in the context of directing support (e.g. N) chemistry for improved...
article 2020
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Casas, M. (author), Chevrier, C. (author), Hond, E.D. (author), Fernandez, M.F. (author), Pierik, F. (author), Philippat, C. (author), Slama, R. (author), Toft, G. (author), Vandentorren, S. (author), Wilhelm, M. (author), Vrijheid, M. (author)
There are emerging concerns about potential effects on child health and development of early-life exposure to substances such as brominated flame retardants (BFRs), perfluorinated compounds (PFCs), phthalates and phenols (including bisphenol A (BPA)); pregnancy and birth cohort studies are ideally designed to study such concerns prospectively....
article 2013
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Strikwold, M. (author), Spenkelink, B. (author), Woutersen, R.A. (author), Rietjens, I.M.C.M. (author), Punt, A. (author)
In vitro assays are often used for the hazard characterisation of compounds, but their application for quantitative risk assessment purposes is limited. This is because in vitro assays cannot provide a complete in vivo dose-response curve from which a point of departure (PoD) for risk assessment can be derived, like the no observed adverse...
article 2013
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Strikwold, M. (author), Woutersen, R.A. (author), Spenkelink, B. (author), Punt, A. (author), Rietjens, I.M.C.M. (author)
The applicability of the embryonic stem cell test (EST) as an alternative for in vivo embryotoxicity testing was evaluated for a series of five p-substituted phenols. To this purpose, the potency ranking for this class of compounds derived from the inhibition of cardiomyocyte differentiation in the EST was compared to in vivo embryotoxic potency...
article 2012
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van Duuren, J.B.J.H. (author), Wijte, D. (author), Karge, B. (author), Martins dos Santos, V.A. (author), Yang, Y. (author), Mars, A.E. (author), Eggink, G. (author)
Pseudomonas putida KT2440-JD1 is able to cometabolize benzoate to cis, cis-muconate in the presence of glucose as growth substrate. P. putida KT2440-JD1 was unable to grow in the presence of concentrations above 50 mM benzoate or 600 mM cis, cis-muconate. The inhibitory effects of both compounds were cumulative. The maximum specific uptake rate...
article 2012
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van Duuren, J.B.J.H. (author), Wijte, D. (author), Leprince, A. (author), Karge, B. (author), Puchalka, J. (author), Wery, J. (author), Dos Santos, V.A.P.M. (author), Eggink, G. (author), Mars, A.E. (author)
Pseudomonas putida KT2440-JD1 was derived from P. putida KT2440 after N-methyl-N'-nitro-N-nitrosoguanidine (NTG)-mutagenesis and exposure to 3-fluorobenzoate (3-FB). The mutant was no longer able to grow using benzoate as a sole carbon source, but co-metabolized benzoate to cis, cis-muconate during growth on glucose, which accumulated in the...
article 2011
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Heerema, L. (author), Wierckx, N. (author), Roelands, C.P.M. (author), Hanemaaijer, J.H. (author), Goetheer, E.L.V. (author), Verdoes, D. (author), Keurentjes, J. (author)
In situ phenol pertraction with 1-octanol has been experimentally studied to improve the production of the model component phenol by a recombinant strain of Pseudomonas putida S12. When the phenol concentration in the reactor reaches 2mM, the cells in fermentations without phenol removal are inhibited in growth and phenol production. Growth and...
article 2011
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van den Berg, C. (author), Boon, F. (author), Roelands, C.P.M. (author), Bussmann, P.J.Th. (author), Goetheer, E.L.V. (author), Verdoes, D. (author), Wielen, L.A.M. (author)
Most fermentation products have a feedback inhibiting effect on the host organism. In situ product recovery (ISPR) can be a means to overcome this product inhibition in fermentations. Particles such as solvent impregnated resins or capsules can be valuable tools for product recovery based on extraction. To evaluate, which kind of particle will...
article 2010
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Hemery, Y.M. (author), Anson, N.M. (author), Havenaar, R. (author), Haenen, G.R.M.M. (author), Noort, M.W.J. (author), Rouau, X. (author), TNO Kwaliteit van Leven (author)
This study evaluated the potential of using ultra-fine grinding and electrostatic separation of wheat bran as methods to improve the bioaccessibility of para-coumaric acid (pCA), sinapic acid (SA) and ferulic acid (FA) from bran-rich breads. Bran fractions were produced and used to bake white bread, whole-grain bread, and seven different bran...
article 2010
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Oudshoorn, A. (author), van den Berg, C. (author), Roelands, C.P.M. (author), Straathof, A.J.J. (author), van der Wielen, L.A.M. (author), TNO Industrie en Techniek (author)
Microorganisms are generally sensitive to high concentrations of products that they excrete. Such product inhibition and toxicity effects can significantly be reduced by the integration of fermentations with separation technologies to remove the products continuously. Cost-calculations are required to select the preferred integration method....
article 2010
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Rouau, X. (author), Mateo-Anson, N. (author), Barron, C. (author), Chaurand, M. (author), Lullien-Pellerin, V. (author), Mabille, F. (author), Samson, M.-F. (author), Abecassis, J. (author), Hemery, Y. (author), TNO Kwaliteit van Leven (author)
Wheat bioactive compounds (fibres, minerals, vitamins, antioxidants) are concentrated in grain outer layers, which constitute the bran fraction obtained after the milling process leading to the white flour. In order to improve the health value of the flours, whole grains can be processed or alternatively, bran fractions can be added to white...
article 2010
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van den Berg, C. (author), Roelands, C.P.M. (author), Bussmann, P.J.Th. (author), Goetheer, E.L.V. (author), Verdoes, D. (author), van der Wielen, L.A.M. (author)
Since the concept of solvent impregnated resins was introduced in the early 1980s, the technique has been applied to a limited amount of applications. The main disadvantage of the resins was that the amount of solvent inside was limited to approximately 1.5 ml/g polymer. A new generation of solvent impregnated resins is introduced. These...
article 2009
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Boot, M. (author), Frijters, P. (author), Luijten, C. (author), Somers, B. (author), Baert, R.S.G. (author), Donkerbroek, A. (author), Klein-Douwel, R.J.H. (author), Dam, N. (author), TNO Industrie en Techniek (author)
Combustion behavior of various oxygenated fuels has been studied in a DAF heavy-duty (HD) directinjection (DI) diesel engine. From these fuels, it is well-known that they lead to lower particle (PM) emissions; however, for a given fuel oxygen mass fraction, there are significant differences in PM reduction. Although this can be traced back to...
article 2009
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Wierckx, N. (author), Ruijssenaars, H.J. (author), de Winde, J.H. (author), Schmid, A. (author), Blank, L.M. (author), TNO Kwaliteit van Leven (author)
The physiological effects of genetic and transcriptional changes observed in a phenol producing mutant of the solvent-tolerant Pseudomonas putida S12 were assessed with metabolic flux analysis. The upregulation of a malate/lactate dehydrogenase encoding gene could be connected to a flux increase from malate to oxaloacetate. A mutation in the...
article 2009
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Verhoef, S. (author), Wierckx, N. (author), Westerhof, R.G.M. (author), de Winde, J.H. (author), Ruijssenaars, H.J. (author), TNO Kwaliteit van Leven (author)
Two solvent-tolerant Pseudomonas putida S12 strains, originally designed for phenol and p-coumarate production, were engineered for efficient production of p-hydroxystyrene from glucose. This was established by introduction of the genes pal and pdc encoding L-phenylalanine/L-tyrosine ammonia lyase and p-coumaric acid decarboxylase, respectively....
article 2009
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Burghoff, B. (author), Goetheer, E.L.V. (author), de Haan, A.B. (author), TNO Industrie en Techniek (author)
The focus of this investigation is the development of a fast and reliable extractant screening approach. Phenol extraction is selected as the model process. A quantum chemical conductor-like screening model for real solvents (COSMO-RS) is combined with molecular design considerations. For this purpose, phenol distribution coefficients KD of...
article 2008
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Angelova, N. (author), Kong, H.-W. (author), van de Heijden, R. (author), Yang, S.-Y. (author), Choi, Y.H. (author), Kim, H.K. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author), Xu, G. (author), Verpoorte, R. (author), TNO Kwaliteit van Leven (author)
This review summarises the most recent developments in ginseng analysis, in particular the novel approaches in sample pre-treatment and the use of high-performance liquid-chromatography-mass spectrometry. The review also presents novel data on analysing ginseng extracts by nuclear magnetic resonance spectroscopy and high-resolution mass...
article 2008
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Ehlert, K.A. (author), Beumer, C.W.E. (author), Groot, M.C.E. (author), TNO Kwaliteit van Leven (author)
A comprehensive migration database was established for bisphenol A from polycarbonate baby bottles into water during exposure to microwave heating. Eighteen different brands of polycarbonate baby bottles sold in Europe were collected. Initial residual content of bisphenol A and migration after microwave heating were determined. Residual content...
article 2008
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Wierckx, N.J.P. (author), Ballerstedt, H. (author), de Bont, J.A.M. (author), de Winde, J.H. (author), Ruijssenaars, H.J. (author), Wery, J. (author), TNO Kwaliteit van Leven (author)
The unknown genetic basis for improved phenol production by a recombinant Pseudomonas putida S12 derivative bearing the tpl (tyrosine-phenol lyase) gene was investigated via comparative transcriptomics, nucleotide sequence analysis, and targeted gene disruption. We show upregulation of tyrosine biosynthetic genes and possibly decreased...
article 2008
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van den Berg, C. (author), Roelands, C.P.M. (author), Bussmann, P.J.Th. (author), Goetheer, E.L.V. (author), Verdoes, D. (author), van der Wielen, L. (author), TNO Kwaliteit van Leven TNO Separation Technolog (author)
The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol...
article 2008
Searched for: subject:"Phenol"
(1 - 20 of 46)

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