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Korst, A.E.C. (author), van der Sterre, M.L.T. (author), Eeltink, C.M. (author), Fichtinger-Schepman, A.M.J. (author), Vermorken, J.B. (author), van der Vijgh, W.J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)We showed previously that amifostine (WR 2721; Ethyol), a protector against carboplatin-induced toxicities, changed the pharmacokinetics of carboplatin in tumor-bearing nude mice. In the present study, the influence of amifostine on the pharmacokinetics of carboplatin was studied in patients when carboplatin was given in combination with three...article 1997
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- Centraal Instituut voor Voedingsonderzoek TNO (author), Mientjes, E.J. (author) doctoral thesis 1996
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- TNO Voeding (author), Hissink, A.M. (author) doctoral thesis 1996
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- TNO Preventie en Gezondheid (author), van Griensven, J.M.T. (author) doctoral thesis 1995
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- TNO Voeding (author), Cassee, F.R. (author) doctoral thesis 1995
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TNO Preventie en Gezondheid (author), Zegers, N.D. (author)Synthetic peptides are useful tools for the generation of antibodies. The use of antibodies as specific reagents in inununochemical assays is widely applied. In this chapter, the application of synthetic peptides for the generation of antibodies is described. The different steps that lead to the unique reagents, such as the selection of the...doctoral thesis 1995
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- TNO Preventie en Gezondheid (author), Twisk, J. (author) doctoral thesis 1994
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de Vries, A.C.J. (author), Vermeer, M.A. (author), Bredman, J.J. (author), Bar, P.R. (author), Cohen, L.H. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)The influence of the 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors pravastatin and simvastatin on lens cholesterol metabolism was investigated in the rat. Short-term organ culture experiments with explanted lenses from 21-day-old Wistar rats showed that simvastatin was at least 35 times more effective than pravastatin in...article 1993
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Instituut voor Milieu- en Energietechnologie TNO Instituut voor Biotechnologie en Chemie TNO (author), de Weger, D. (author), Feron, V.J. (author), Zwart, A. (author), de Vrijer, F. (author)Door de Afdeling Industriële Veiligheid van IMET-TNO (Instituut voor Milieu- en Energietechnologie, Hoofdgroep Milieu en Energie te Apeldoorn) en de Afdeling Biologische Toxicologie van ITV-TNO (Instituur voor Toxicologie en voeding, Hoofdgroep Voeding te Zeist) is het project 'Gezondheidsschade door calamiteiten met Gevaarlijke Stoffen' (GSGS)...report 1993
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- Nederlands Instituut voor Praeventieve Gezondheidszorg (author), Wijlhuizen, G.J. (author), Güttinger, V.A. (author), Hofman, A. (author) report 1993
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Zwart, A. (author), Arts, J.H.E. (author), ten Berge, W.F. (author), Appelman, L.M. (author)A new design for acute inhalation toxicity testing was evaluated and compared with results obtained according to OECD guideline 403. The new design consists of a range-finding test, which is compatible with a conventional limit test, and can be followed by determination of a concentration-time-mortality relationship, enabling calculation of LC50...article 1992
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Emeis, J.J. (author), van den Hoogen, C.M. (author), Gaubius Laboratory IVVO-TNO, P.O. Box 430, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)Pharmacological modulation of the in vivo induction of plasminogen activator inhibitor type-1 (PAI-1) synthesis was studied in rats using the induction of PAI-1 by endotoxin as a model system. Both the cyclooxygenase inhibitors acetylsalicylic acid and indomethacin enhanced PAI-1 induction. The combined cyclooxygenase-lipoxygenase inhibitor,...article 1992
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- Gezondheidsorganisatie TNO Gaubius instituut TNO (author), Tranquille-Mouchabeck, N. (author) doctoral thesis 1991
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- Instituut voor verouderings- en vaatziekten onderzoek TNO Instituut voor experimentele gerontologie TNO (author), Stijnen, A.M. (author) doctoral thesis 1991
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- Instituut voor Toegepaste Radiobiologie en Immunologie TNO (author), Kornet, L.M.W. (author) doctoral thesis 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Reuzel, P.G.J. (author), Bruijntjes, J.P. (author), Feron, V.J. (author), Woutersen, R.A. (author)The inhalation toxicity of three amorphous silicas (Aerosol 200, Aerosil R 974 and Sipernat 22S) was compared with that of quartz dust. Rast were exposed to 1, 6 or 30 mg Aerosil 200/m3, 30 mg Aerosil R 974/m3, 30 mg Sipernat 22S/m3 or 60 mg quartz/m3 for 6 hr/day, 5 day/wk for 13 wk. Some rats were killed at the end of the exposure period and...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Groten, J.P. (author), Sinkeldam, E.J. (author), Muys, T. (author), Luten, J.B. (author), van Bladeren, P.J. (author)The toxicity of Cd was examined in rats fed diets containing 30 mg Cd/kg as CdCl2 for 8 wk. The Cd-containing diets were supplemented with various combinations of the minerals Ca, P, Mg, Mn, Cu, Fe, Zn and Se in order to investigate the protective effect of these mineral combinations on Cd accumulation and toxicity. The mineral combinations were...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Monks, T.J. (author), Anders, M.W. (author), Dekant, W. (author), Stevens, J.L. (author), Lau, S.S. (author), van Bladeren, P.J. (author)Glutathione (γ-glutamyl-l-cysteinylglycine; GSH) is present in high concentrations in most living cells and participates in a variety of vital cellular reactions. In particular, GSH protects cells from potentially toxic electrophiles formed via the metabolism of xenobiotics, and such reactions have long been associated with the process of...article 1990
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- Odink, J. (author), Korthals, H. (author), Vette, G.M. (author) article 1987
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- Instituut CIVO-Toxicologie en Voeding TNO (author), Feron, V.J. (author) article 1987