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- van der Beek, E.J. (author), Inklaar, H. (author), Centraal instituut voor voedingsonderzoek TNO (author) bookPart 1985
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Koëter, H.B.W.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Toxicity data of 37 compounds tested in both a subchronic study and one or more studies focused on reproduction were evaluated to obtain information on the significance of fertility and reproduction parameters in setting no-effect levels (NEL). It appeared that a) the test system aimed at reproduction and development was more sensitive than the...article 1983
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Nieuwenhuizen, W. (author), Voskuilen, M. (author), Hermans, J. (author), Gaubius instituut TNO (author)The present study was undertaken as a step to delineate further the localization of the calcium-binding sites in fibrinogen and to assess the anticlotting properties of fibrinogen degradation products. To this purpose, fragments Y were prepared by plasmin digestion of human fibrinogen in the presence of added Ca2+, and purified. We found that,...article 1982
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- Gezondheidsorganisatie TNO Commissie voor landelijk epilepsie-onderzoek TNO (author), Hollinger, J.L. (author), Hommes, O.R. (author), van der Wiel, T.J.J.M. (author), Kok, J.C.N. (author), Jansen, M.J.T. (author) article 1982
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- Schellekens, H. (author), Primatencentrum TNO (author) article 1981
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Sonneveld, P. (author), van den Engh, G.J. (author), Radiobiologisch Instituut TNO (author)Flow cytometry was used to measure the uptake of adriamycin (AM) and daunomycin (DM) by various cell types of the haemopoietic organs and by acute myeloid leukemia (AML) cells. For this purpose, the spontaneous fluorescence of the drugs upon excitation with laser light at 488 nm was measured. The difference in the uptake of these two drugs...article 1981
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- Gezondheidsorganisatie TNO Commissie voor landelijk epilepsie-onderzoek TNO (author), Lindhout, D. (author), Meinardi, H. (author), Barth, P.G. (author) other 1981
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Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 hr/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal...article 1978
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Dries, W.J.H. (author), Schreurs, W.H.P. (author), Buyze, G. (author), Centraal instituut voor voedingsonderzoek TNO (author)Pauling introduced the concept of orthomolecular psychiatry. According to this concept, the treatment of mental disease should benefit by optimalisation of the molecular environment of the mind. In this connection, the effect of multiple vitamin administration has been studied in 73 hospitalised psychiatrie patients who were divided in two equal...article 1978
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- Leegwater, D.C. (author) article 1978
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- Centraal instituut voor voedingsonderzoek TNO (author), Clary, J.J. (author), Feron, V.J. (author), Reuzel, P.G. (author) article 1978
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Seinen, W. (author), Willems, M.I. (author)Rats were fed di-n-octyltindichloride (DOTC) for 6 weeks at dietary levels of 0, 50, or 150 ppm. At 150 ppm, slight but significant growth retardation associated with slightly decreased food efficiency was noted. Serum alkaline phosphatase (AP) activity was significantly increased both at 50 and 150 ppm. This increase in serum activity was...article 1976
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- Chemisch laboratorium TNO (author) book 1973
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- Nelemans, F.A. (author), TNO Preventie en Gezondheid Klinisch Geneesmiddelenonderzoek TNO (author) article 1972
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- TNO Industrie (author) book 1972
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- Luijten, J.G.A. (author), Organisch Chemisch Instituut TNO (author) other 1971
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- Centraal Instituut voor Voedingsonderzoek TNO (author), Winkler, K.C. (author), Flipse, L.P. (author), Wensinck, F. (author), Manten, A. (author), Labots, H. (author), Zwart, H. (author), van der Schaaf, A. (author), Schipper, (author), Galesloot, T.E. (author), Sand, F. (author), Mouton, P.P. (author) conference paper 1968
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- Klinisch Geneesmiddelenonderzoek TNO (author), Zegvelder, W.G. (author), Nelemans, F.A. (author) article 1967
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- Nelemans, F.A. (author), TNO Preventie en Gezondheid Klinisch Geneesmiddelenonderzoek TNO (author) article 1966
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- Nelemans, F.A. (author), Klinisch Geneesmiddelenonderzoek TNO (author) bookPart 1966