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Physiology and pharmacology of temperature regulation: From basic to applied and across environmentsKingma, B.R.M. (author), Charkoudian, N. (author), White, M. (author)A Call for papers on the theme of Physiology and Pharmacology of Temperature Regulation (PPTR) was announced by Andrej Romanovsky, the Editor-in-Chief of Temperature during the virtual PPTR (vPPTR) 2020 conference that was held from Oct 26–29, 2020. During vPPTR 2020 Editor Romanovsky invited each of us as Guest Editors for this initiative and...article 2022
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Bourgonje, A.R. (author), Offringa, A.K. (author), van Eijk, L.E. (author), Abdulle, A.E. (author), Hillebrands, J.L. (author), van der Voort, P.H.J. (author), van Goor, H. (author), van Hezik, E.J. (author)Significance: Hydrogen sulfide (H2S) is one of the three main gasotransmitters that are endogenously produced in humans and are protective against oxidative stress. Recent findings from studies focusing on coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shifted our attention to a...article 2021
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de Ligt, R. (author), van Duijn, E. (author), Grossouw, D. (author), Bosgra, S. (author), Burggraaf, J. (author), Windhorst, A. (author), Peeters, P.A.M. (author), van der Luijt, G.A. (author), Alexander-White, C. (author), Vaes, W.H.J. (author)A clinical pharmacokinetic study was performed in 12 healthy women to evaluate systemic exposure to aluminum following topical application of a representative antiperspirant formulation under real-life use conditions. A simple roll-on formulation containing an extremely rare isotope of aluminum (26 Al) chlorohydrate (ACH) was prepared to...article 2018
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Swart, P. (author), Lozac'h, F. (author), Simon, M. (author), van Duijn, E. (author), Vaes, W.H. (author)Modern accelerator mass spectrometry (AMS) methods enable the routine application of this technology in drug development. By the administration of a (14)C-labelled microdose or microtrace, pharmacokinetic (PK) data, such as mass balance, metabolite profiling, and absolute bioavailability (AB) data, can be generated easier, faster, and at lower...article 2016
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van der Laan, J.W. (author), Buitenhuis, W.H.W. (author), Wagenaar, L. (author), Soffers, A.E.M.F. (author), van Someren, E.P. (author), Krul, C.A.M. (author), Woutersen, R.A. (author)In an exercise designed to reduce animal use, we analyzed the results of rat subchronic toxicity studies from 289 pharmaceutical compounds with the aim to predict the tumor outcome of carcinogenicity studies in this species. The results were obtained from the assessment reports available at the Medicines Evaluation Board of the Netherlands for...article 2016
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Kemmerling, J. (author), Fehlert, E. (author), Kuper, C.F. (author), Rühl-Fehlert, C. (author), Stropp, G. (author), Vogels, J. (author), Krul, C. (author), Vohr, H.W. (author)Exposure to chemicals may have an influence on the immune system. Often, this is an unwanted effect but in some pharmaceuticals, it is the intended mechanism of action. Immune function tests and in depth histopathological investigations of immune organs were integrated in rodent toxicity studies performed according to an extended OECD test...article 2015
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van Stiphout, F. (author), Zwart-van Rijkom, J.E.F. (author), Maggio, L.A. (author), Aarts, J.E.C.M. (author), Bates, D.W. (author), van Gelder, T. (author), Jansen, P.A.F. (author), Schraagen, J.M.C. (author), Egberts, A.C.G. (author), ter Braak, E.W.M.T. (author)Aims Educating physicians in the procedural as well as cognitive skills of information technology (IT)-mediated medication management could be one of the missing links for the improvement of patient safety. We aimed to compose a framework of tasks that need to be addressed to optimize medication management in outpatient care. Methods Formal task...article 2015
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Schiffelers, M.J.W.A. (author), Blaauboer, B.J. (author), Bakker, W.E. (author), Beken, S. (author), Hendriksen, C.F.M. (author), Koeter, H. (author), Krul, C.A.M. (author)Pharmaceuticals and chemicals are subjected to regulatory safety testing accounting for approximately 25% of laboratory animal use in Europe. This testing meets various objections and has led to the development of a range of 3R models to Replace, Reduce or Refine the animal models. However, these models must overcome many barriers before being...article 2014
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van den Hoek, A.M. (author), van der Hoorn, J.W.A. (author), Maas, A.C. (author), van den Hoogen, R.M. (author), van Nieuwkoop, A. (author), Droog, S. (author), Offerman, E.H. (author), Pieterman, E.J. (author), Havekes, L.M. (author), Princen, H.M.G. (author)Aims: This study aimed to investigate systematically (i) the appropriate dietary conditions to induce the features of the MetS in APOE*3Leiden.humanCholesteryl Ester Transfer Protein (E3L.CETP) mice and (ii) whether the response of this model to different antidiabetic and hypolipidemic drugs is similar as in humans. Methods: Male obese, IR and...article 2014
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Gozalpour, E. (author), Greupink, R. (author), Wortelboer, H.M. (author), Bilos, A. (author), Schreurs, M. (author), Russel, F.G.M. (author), Koenderink, J.B. (author)Digitalis-like compounds (DLCs) such as digoxin, digitoxin, and ouabain, also known as cardiac glycosides, are among the oldest pharmacological treatments for heart failure. The compounds have a narrow therapeutic window, while at the same time, DLC pharmacokinetics is prone to drug-drug interactions at the transport level. Hepatic transporters...article 2014
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Wei, W. (author), Clockaerts, S. (author), Bastiaansen-Jenniskens, Y.M. (author), Gierman, L.M. (author), Botter, S.M. (author), Bierma-Zeinstra, S.M.A. (author), Weinans, H. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), Zuurmond, A.M. (author), van Osch, G.J.V.M. (author)Objective: Since statins and fibrates are capable of improving the metabolic profile of patients as well as decreasing inflammation, they are considered as potential drugs for preventing osteoarthritis (OA). The goal of the present study was to investigate the effect of these drugs in the STR/Ort spontaneous OA mouse model. Design: Male STR/Ort...article 2014
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Buist, H. (author), Aldenberg, T. (author), Batke, M. (author), Escher, S. (author), Kühne, R. (author), Marquart, H. (author), Pauné, E. (author), Rorije, E. (author), Schüürmann, G. (author), Kroese, D.E. (author)Risk assessment of chemicals usually implies data evaluation of in vivo tests in rodents to conclude on 31 their hazards. The FP7 European project OSIRIS has developed integrated testing strategies (ITS) for rel- 32 evant toxicological endpoints to avoid unnecessary animal testing and thus to reduce time and costs. This 33 paper describes the...article 2013
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Vermeire, T. (author), Aldenberg, T. (author), Buist, H. (author), Escher, S. (author), Mangelsdorf, I. (author), Pauné, E. (author), Rorije, E. (author), Kroese, D.E. (author)Chemical substances policies in Europe are aiming towards chemical safety and at the same time a reduction in animal testing. These goals are alleged to be reachable by mining as many relevant data as possible, evaluate these data with regard to validity, reliability and relevance, and use of these data in so-called Integrated Testing Strategies...article 2013
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van Wouwe, N.C. (author), Ridderinkhof, K.R. (author), Band, G.P.H. (author), van den Wildenberg, W.P.M. (author), Wylie, S.A. (author)Learning to select optimal behavior in new and uncertain situations is a crucial aspect of living and requires the ability to quickly associate stimuli with actions that lead to rewarding outcomes. Mathematical models of reinforcement-based learning to select rewarding actions distinguish between (1) the formation of stimulus-action-reward...article 2012
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Maathuis, A.J.H. (author), van den Heuvel, E.G. (author), Schoterman, M.H.C. (author), Venema, K. (author)Galacto-oligosaccharides (GOS) are considered to be prebiotic, although the contribution of specific members of the microbiota to GOS fermentation and the exact microbial metabolites that are produced upon GOS fermentation are largely unknown. We aimed to determine this using uniformly 13C-labeled GOS. The normal (control) medium and unlabeled...article 2012
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Rose, R.J. (author), Thompson, N.J. (author), Van Duijn, E. (author), Damoc, E. (author), Denisov, E. (author), Makarov, A. (author), Heck, A.J.R. (author)Monoclonal antibodies (mAbs) represent a major class of therapeutic biomolecules being developed by the biopharmaceutical industry, their popularity largely being a result of their high specificity towards targets. Therapeutic mAbs are being developed for various diseases, with a strong focus on cancer and immunological disorders.[1] All...article 2012
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Buscher, B.A.P. (author), Jägfeldt, H. (author), Sandman, H. (author), Brust-van Schaik, R. (author), van Schaik, F. (author), Brüll, L.P. (author)A bioanalytical method for the quantitative determination of budesonide and fluticasone in human sputum was developed. Sputolysin ® Reagent was added to the sputum samples. After incubation (37°C; 60-70min under shaking) and automated solid phase extraction the extracts were analysed using LC-MS/MS. Budesonide and fluticasone showed good...article 2012
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Vos, P.A.J.M. (author), Mastbergen, S.C. (author), Huisman, A.M. (author), de Boer, T.N. (author), de Groot, J. (author), Polak, A.A. (author), Lafeber, F.P.J.G. (author)Objectives: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence...article 2012
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Kuper, C.F. (author), Ernst, H. (author), van Oostrum, L.C.M. (author), Rittinghausen, S. (author), Penninks, A.H. (author), Ganderup, N.-C. (author), Wolterbeek, A.P.M. (author)Histopathological examination of the nasal passages requires a standardized approach for recording lesion distribution patterns. Nasal diagrams provide guidance to map the lesions. Information on lesions exists for rodents, dogs, and monkeys, which all have been used in inhalation studies. Recently, minipigs have garnered interest as an...article 2012
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Wei, H. (author), Hu, C. (author), Wang, M. (author), van den Hoek, A.M. (author), Reijmers, T.H. (author), Wopereis, S. (author), Bouwman, J. (author), Ramaker, R. (author), Korthout, H.A.A.J. (author), Vennik, M. (author), Hankemeier, T. (author), Havekes, L.M. (author), Witkamp, R.F. (author), Verheij, E.R. (author), Xu, G. (author), van der Greef, J. (author)Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese...article 2012