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Tsakirakis, A.N. (author), Kasiotis, K.M. (author), Glass, R.C. (author), Charistou, A.N. (author), Anastasiadou, P. (author), Gerritsen-Ebben, R.M. (author), Machera, K. (author)Dermal transfer of pesticide residues to human skin due to contact with treated crops, treated surfaces, or contaminated surfaces is an important route of exposure for operators, workers and possibly for bystanders and residents. However, information on dermal transfer data is limited and mainly available for workers. The aim of the present...article 2022
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Figueiredo, D.M. (author), Nijssen, R. (author), Krop, E.J.M. (author), Buijtenhuijs, D. (author), Gooijer, Y. (author), Lageschaar, L. (author), Duyzer, J. (author), Huss, A. (author), Mol, H. (author), Vermeulen, R.C.H. (author)Indoor dust has been postulated as an important matrix for residential pesticide exposure. However, there is a lack of information on presence, concentrations and determinants of multiple pesticides in dust in residential homes close to treated fields. Our objective was to characterize the spatial and temporal variance of pesticides in house...article 2022
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Figueiredo, D.M. (author), Krop, E.J.M. (author), Duyzer, J. (author), Gerritsen-Ebben, R.M. (author), Gooijer, Y.M. (author), Holterman, H.J. (author), Huss, A. (author), Jacobs, C.M.J. (author), Kivits, C.M. (author), Kruijne, R. (author), Mol, H.J.G.J. (author), Oerlemans, A. (author), Sauer, P.J.J. (author), Scheepers, P.T.J. (author), van de Zande, J.C. (author), van den Berg, E. (author), Wenneker, M. (author), Vermeulen, R.C.H. (author)Background: Application of pesticides in the vicinity of homes has caused concern regarding possible health effects in residents living nearby. However, the high spatiotemporal variation of pesticide levels and lack of knowledge regarding the contribution of exposure routes greatly complicates exposure assessment approaches. Objective: The...article 2021
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Figueiredo, D. (author), Duyzer, J. (author), Huss, A. (author), Krop, E.J.M. (author), Gerritsen-Ebben, M.G. (author), Gooijer, Y. (author), Vermeulen, R.C.H. (author)Background: Previous research has shown that many current-use pesticides can be detected in air around application areas. Environmental exposure to pesticides may cause adverse health effects, necessitating accurate assessment of outdoor and indoor air concentrations for people living close to spraying sites. We evaluated outdoor and indoor air...article 2021
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Onder, S. (author), van Grol, M. (author), Fidder, A. (author), Xiao, G. (author), Noort, D. (author), Yerramalla, U. (author), Tacal, O. (author), Schopfer, L.M. (author), Lockridge, O. (author)Chronic low-dose exposure to organophosphorus pesticides is associated with the risk of neurodegenerative disease. The mechanism of neurotoxicity is independent of acetylcholinesterase inhibition. Adducts on tyrosine, lysine, threonine, and serine can occur after exposure to organophosphorus pesticides, the most stable being adducts on tyrosine....article 2021
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Spaan, S. (author), Glass, R. (author), Goede, H. (author), Ruiter, S. (author), Gerritsen-Ebben, R.M. (author)The suitability, availability, and use of protective clothing are critical factors determining the actual dermal exposure (ADE) of operators and workers to pesticides. A realistic assessment of occupational exposure to pesticides requires information about the performance of protective clothing during everyday use. In this study, the performance...article 2020
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van den Dries, M.A. (author), Lamballais, S. (author), El Marroun, H. (author), Pronk, A. (author), Spaan, S. (author), Ferguson, K.K. (author), Longnecker, M.P. (author), Tiemeier, H. (author), Guxens, M. (author)Background: Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine...article 2020
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- de Weert, J. (author), Smedes, F. (author), Beeltje, H. (author), de Zwart, D. (author), Hamers, T. (author) article 2020
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Heusinkveld, H. (author), Braakhuis, H. (author), Gommans, R. (author), Botham, P. (author), Corvaro, M. (author), van der Laan, J.W. (author), Lewis, D. (author), Madia, F. (author), Manou, I. (author), Schorsch, F. (author), Wolterink, G. (author), Woutersen, R. (author), Corvi, R. (author), Mehta, J. (author), Luijten, M. (author)Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health risks. For agrochemicals, the long-term rodent carcinogenicity study is currently required from a regulatory perspective. Although it is the current mainstay for the detection of nongenotoxic...article 2020
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van den Dries, M.A. (author), Guxens, M. (author), Pronk, A. (author), Spaan, S. (author), El Marroun, H. (author), Jusko, T.A. (author), Longnecker, M.P. (author), Ferguson, K.K. (author), Tiemeier, H. (author)Background: Prenatal exposure to organophosphate (OP) pesticides has been associated with altered neuronal cell development and behavioral changes in animal offspring. However, the few studies investigating the association between prenatal OP pesticide exposure and neurodevelopmental outcomes such as Attention-Deficit Hyperactivity Disorder ...article 2019
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Tsakirakis, A.N. (author), Kasiotis, K.M. (author), Anastasiadou, P. (author), Charistou, A.N. (author), Gerritsen-Ebben, R. (author), Glass, C.R. (author), Machera, K. (author)BACKGROUND: In the present study, the rate of dermal transfer of pesticides to agricultural workers occurring via contact with sprayed hard surfaces was investigated. Cotton gloves were used as dosimeters to collect residues from hard surfaces contaminated by pesticides in greenhouses. Dosimeters, either dry or moistened, were in contact with...article 2018
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Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Richard Glass, C. (author), Charistou, A.N. (author), Anastassiadou, P. (author), Gerritsen-Ebben, R. (author), Machera, K. (author)A dislodgeable foliar residue study was conducted in greenhouse pepper and tomato on the island of Crete, Greece, following the spray application of an SC insecticide (with active substance (a.s.) tebufenozide) and an EC fungicide (a.s. bupirimate). Furthermore, for the assessment of worker exposure to pesticides – as a result of re-entering the...article 2017
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Buist, H.E. (author), Krul, L. (author), Leeman, W.R. (author)To derive an acute TTC threshold, the correlation between Allowable Daily Intakes (ADIs, chronic values) and Acute Reference Doses (ARfDs) of pesticides evaluated in the EU was investigated and their distributions were compared. The correlation between ARfDs and ADIs was significant (p ¼ 0.01), but weak (r2 ¼ 0.051). Consequently, using this...article 2016
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Sacchettini, G. (author), Calliera, M. (author), Marchis, A. (author), Glass, R. (author), Ellis, C.B. (author), Machera, K. (author), Gerritsen-Ebben, R. (author), Spanoghe, P. (author), Capri, E. (author)In 2009, the European Union adopted the Directive on Sustainable Use of pesticides (SUD, Directive 2009/128/EC) establishing a framework for achieving a sustainable use of Plant Protection Products (PPPs) through reducing the risks and impacts of PPP use on human health and the environment, promoting integrated pest management and stimulating...article 2015
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Remoundou, K. (author), Brennan, M. (author), Sacchettini, G. (author), Panzone, L. (author), Butler-Ellis, M.C. (author), Capri, E. (author), Charistou, A. (author), Chaideftou, E. (author), Gerritsen-Ebben, M.G. (author), Machera, K. (author), Spanoghe, P. (author), Glass, R. (author), Marchis, A. (author), Doanngoc, K. (author), Hart, A. (author), Frewer, L.J. (author)The EU Directive on the sustainable use of pesticides (EU128/2009/EC) requires European Member States to develop training activities targeting occupational exposure to pesticides, and communication material aimed at residents and bystanders. Risk perceptions, knowledge and attitudes associated with passive and occupational exposure to pesticide...article 2015
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Spaan, S. (author), Pronk, A. (author), Koch, H.M. (author), Jusko, T.A. (author), Jaddoe, V.M.W. (author), Shaw, P.A. (author), Tiemeier, H.M. (author), Hofman, A. (author), Pierik, F.H. (author)The widespread use of organophosphate (OP) pesticides has resulted in ubiquitous exposure in humans, primarily through their diet. Exposure to OP pesticides may have adverse health effects, including neurobehavioral deficits in children. The optimal design of new studies requires data on the reliability of urinary measures of exposure. In the...article 2015
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Remoundou, K. (author), Brennana, M. (author), Sacchettini, G. (author), Panzone, L. (author), Butler-Ellis, M.C. (author), Capri, E. (author), Charistou, A. (author), Chaideftou, E. (author), Gerritsen-Ebben, M.G. (author), Machera, K. (author), Spanoghe, P. (author), Glass, R. (author), Marchis, A. (author), Doanngoc, K. (author), Hart, A. (author), Frewer, L.J. (author)The EU Directive on the sustainable use of pesticides (EU128/2009/EC) requires European Member States to develop training activities targeting occupational exposure to pesticides, and communication material aimed at residents and bystanders. Risk perceptions, knowledge and attitudes associated with passive and occupational exposure to pesticide...article 2015
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Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...article 2014
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van der Schans, M.J. (author), Hulst, A.G. (author), van der Riet-Van Oeveren, D. (author), Noort, D. (author), Benschop, H.P. (author), Dishovsky, C. (author)Organophosphate (OP) pesticides are neurotoxic compounds that are widely used in agriculture. Classical methods for monitoring OP exposure comprise the measurement of intact OP, its metabolites or cholinesterase activity. Newly developed methods focus on the analysis of the OP adduct bound to proteins such as butyrylcholinesterase (BuChE) and...article 2013
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Noort, D. (author), Hulst, A.G. (author), van Zuylen, A. (author), van Rijssel, E. (author), van der Schans, M.J. (author), TNO Defensie en Veiligheid (author)We here report on the covalent binding of various organophosphorothioate (OPT) pesticides to albumin at in vitro exposure levels that did not give rise to butyrylcholinesterase inhibition. Adduct formation occurred at the Tyr-411 residue of albumin, as was firmly corroborated by LC-tandem MS analysis of a pepsin digest of OPT-modified albumin....article 2009