Searched for: subject:"Peptides"
(1 - 20 of 177)

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Noort, D. (author), Fidder, A. (author), van der Riet-van Oeveren, D. (author), Busker, R.W. (author), van der Schans, M.J. (author)
Novichok (NV) nerve agents were recently added to the list of Schedule 1 chemicals of the Chemical Weapons Convention. There is a well-accepted method for assessment of nerve agent exposure based on mass spectrometric analysis of a nonapeptide with the serine-198 residue modified by the nerve agent, but this approach has not yet been reported...
article 2021
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van der Does, A.M. (author), Amatngalim, G.D. (author), Keijser, B.J.F. (author), Hiemstra, P.S. (author), Villenave, R. (author)
The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of...
article 2018
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Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...
article 2018
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Zarcone, M.C. (author), van Schadewijk, A. (author), Duistermaat, E. (author), Hiemstra, P.S. (author), Kooter, I.M. (author)
Background: Exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus influenzae (NTHi), and exposures to diesel engine emissions are known to contribute to exacerbations in COPD patients....
article 2017
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de Marchi, T. (author), Braakman, R.B.H. (author), Stingl, C. (author), van Duijn, M.M. (author), Smid, M. (author), Foekens, J.A. (author), Luider, T.M. (author), Martens, J.W.M. (author), Umar, A. (author)
article 2016
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Ripken, D. (author), van der Wielen, N. (author), van der Meulen, J. (author), Schuurman, T. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author), Koopmans, S.J. (author)
The vagal nerve and gut hormones CCK and GLP-1 play important roles in the control of food intake. However, it is not clear to what extent CCK and GLP-1 increase satiation by stimulating receptors located on abdominal vagal nerve endings or via receptors located elsewhere. This study aimed to further explore the relative contribution of the...
article 2015
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van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Hendriks, H.F. (author), Aam, M. (author)
BACKGROUND: Activation of the ileal brake, by infusing lipid directly into the distal part of the small intestine, alters gastrointestinal (GI) motility and inhibits food intake. The ileal brake effect on eating behavior of the other macronutrients is currently unknown. OBJECTIVE: The objective of this study was to investigate the effects of...
article 2015
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van Avesaat, M. (author), Troost, F.J. (author), Ripken, D. (author), Peters, J. (author), Hendriks, H.F.J. (author), Masclee, A.A.M. (author)
Background: Taste receptors are expressed not only in taste buds but also in the gastrointestinal tract. It has been hypothesized that these receptors may play a role in satiety and food intake. Objective: This study investigated the effect of intraduodenal tastant infusions (bitter, sweet, and umami) on food intake, hunger and fullness,...
article 2015
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Kühnast, S. (author), Fiocco, M. (author), van der Hoorn, J.W.A. (author), Princen, H.M.G. (author), Jukema, J.W. (author)
Non-HDL-cholesterol is well recognised as a primary causal risk factor in cardiovascular disease. However, despite consistent epidemiological evidence for an inverse association between HDL-C and coronary heart disease, clinical trials aimed at raising HDL-C (AIM-HIGH, HPS2-THRIVE, dal-OUTCOMES) failed to meet their primary goals. This...
article 2015
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Neumann, A. (author), Völlger, L. (author), Berends, E.T.M. (author), Molhoek, E.M. (author), Stapels, D.A.C. (author), Midon, M. (author), Friães, A. (author), Pingoud, A. (author), Rooijakkers, S.H.M. (author), Gallo, R.L. (author), Mörgelin, M. (author), Nizet, V. (author), Naim, H.Y. (author), von Köckritz-Blickwede, M. (author)
Neutrophil extracellular traps (NETs) have been described as a fundamental innate immune defence mechanism. They consist of a nuclear DNA backbone associated with different antimicrobial peptides (AMPs) which are able to engulf and kill pathogens. The AMP LL-37, a member of the cathelicidin family, is highly present in NETs. However, the...
article 2014
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Neumann, A. (author), Berends, E.T.M. (author), Nerlich, A. (author), Molhoek, E.M. (author), Gallo, R.L. (author), Meerloo, T. (author), Nizet, V. (author), Naim, H.Y. (author), von Köckritz-Blickwede, M. (author)
NETs (neutrophil extracellular traps) have been described as a fundamental innate immune defence mechanism. Duringformation of NETs, the nuclear membrane is disrupted by an asyet unknown mechanism. In the present study we investigated the role of human cathelicidin LL-37 in nuclear membrane disruption and formation of NETs. Immunofluorescence...
article 2014
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Ripken, D. (author), van der Wielen, N. (author), Wortelboer, H.M. (author), Meijerink, J. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)
Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are hormones important for satiation and are involved in the process called “ileal brake”. The aim of this study was to investigate the GLP-1- and PYY-stimulating efficacy of rebaudioside A, casein, and sucrose. This was studied using tissue segments collected from various regions of the pig...
article 2014
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Gvaramia, D. (author), Blaauboer, M.E. (author), Hanemaaijer, R. (author), Everts, V. (author)
Fibrosis underlies the pathogenesis of numerous diseases and leads to severe damage of vital body organs and, frequently, to death. Better understanding of the mechanisms resulting in fibrosis is essential for developing appropriate treatment solutions and is therefore of upmost importance. Recent evidence suggests a significant antifibrotic...
article 2013
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Kaman, W.E. (author), Voskamp-Visser, I. (author), de Jongh, D.M.C. (author), Endtz, H.P. (author), van Belkum, A. (author), Hays, J.P. (author), Bikker, F.J. (author)
Bacterial proteases play an important role in a broad spectrum of processes, including colonization, proliferation, and virulence. In this respect, bacterial proteases are potential biomarkers for bacterial diagnosis and targets for novel therapeutic protease inhibitors. To investigate these potential functions, the authors designed and used a...
article 2013
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Kapoerchan, V.V. (author), Knijnenburg, A.D. (author), Keizer, P. (author), Spalburg, E. (author), de Neeling, A.J. (author), Mars-Groenendijk, R.H. (author), Noort, D. (author), Otero, J.M. (author), Llamas-Saiz, A.L. (author), van Raaij, M.J. (author), van der Marel, G.A. (author), Overkleeft, H.S. (author), Overhand, M. (author)
A series of gramicidin S derivatives 4-15 are presented that have four ornithine residues as polar protonated side chains and two central hydrophobic amino acids with unaltered turn regions. These peptides were screened against human erthrocytes and our standard panel of Gram negative- and Gram positive bacteria, including four MRSA strains....
article 2012
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Lindenburg, P.W. (author), Tempels, F.W.A. (author), Tjaden, U.R. (author), van der Greef, J. (author), Hankemeier, T. (author)
Electroextraction (EE) takes place in a two-phase liquid-liquid system, consisting of an aqueous and an organic phase, where an applied electric field causes ions to be extracted from one phase into the other, to be concentrated close after the liquid-liquid interface. The extraction takes place in a wide-bore capillary that is connected to a 2...
article 2012
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Knijnenburg, A.D. (author), Spalburg, E. (author), de Neeling, A.J. (author), Mars-Groenendijk, R.H. (author), Noort, D. (author), Grotenbreg, G.M. (author), van der Marel, G.A. (author), Overkleeft, H.S. (author), Overhand, M. (author)
This article presents a series of ring-extended gramicidin S derivatives, 9-14, that have four ornithine residues as polar protonated side chains and one modified turn region containing a mono-functionalized cis-δ-oxetane, δ-furanoid, or δ-pyranoid sugar amino acid residue. Of the GS analogs evaluated, we identified compound 7, which contains...
article 2012
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Molhoek, E.M. (author), van Dijk, A. (author), Veldhuizen, E.J.A. (author), Haagsman, H.P. (author), Bikker, F.J. (author)
Staphylococcus epidermidis is a major cause of nosocomial infections owing to its ability to form biofilms on the surface of medical devices. Biofilms are surface-adhered bacterial communities. In mature biofilms these communities are encased in an extracellular matrix composed of bacterial polysaccharides, proteins and DNA. The antibiotic...
article 2011
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Molhoek, E.M. (author)
doctoral thesis 2011
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Knijnenburg, A.D. (author), Kapoerchan, V.V. (author), Grotenbreg, G.M. (author), Spalburg, E. (author), de Neeling, A.J. (author), Mars-Groenendijk, R.H. (author), Noort, D. (author), Otero, J.M. (author), Llamas-Saiz, A.L. (author), van Raaij, M.J. (author), Ravensbergen, B. (author), Nibbering, P.H. (author), van der Marel, G.A. (author), Overkleeft, H.S. (author), Overhand, M. (author)
In this paper, we describe the crystal structure of previously reported ring-extended gramicidin S (GS) derivative 2 (GS14K4), containing a d-amino acid residue in one of the β-strand regions. This structure is in agreement with a previously reported modeling study of the same molecule. The polar side chain of the additional d-amino acid residue...
article 2011
Searched for: subject:"Peptides"
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