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van Nieuw Amerongen, G.P. (author), Koolwijk, P. (author), Versteilen, A. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Objective - Growth factor-induced angiogenesis involves migration of endothelial cells (ECs) into perivascular areas and requires active remodeling of the endothelial F-actin cytoskeleton. The small GTPase RhoA previously has been implicated in vascular endothelial growth factor (VEGF)-induced signaling pathways, but its role has not been...
article 2003
van Hinsbergh, V.W.M. (author), Sprengers, E.D. (author), Kooistra, T. (author), Gaubius Instituut TNO (author)
Human foreskin microvascular endothelial cells synthesize and release tissue-type plasminogen activator (t-PA) in similar amounts as do endothelial cells from umbilical cord artery and vein. Human thrombin increases the production of t-PA by these cells, which could be visualized from 8 h after addition of 0.1-5 units/ml thrombin by fibrin...
article 1987