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Streekstra, E.J. (author), Kiss, M. (author), van den Heuvel, J. (author), Nicolaï, J. (author), van den Broek, P. (author), Botden, S.M.B.I. (author), Stommel, M.W.J. (author), van Rijssel, L. (author), Ungell, A.L. (author), van de Steeg, E. (author), Russel, F.G.M. (author), de Wildt, S.N. (author)Little is known about the impact of age on the processes governing human intestinal drug absorption. The Ussing chamber is a system to study drug transport across tissue barriers, but it has not been used to study drug absorption processes in children. This study aimed to explore the feasibility of the Ussing chamber methodology to assess...article 2022
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van Dommelen, P. (author), van Zoonen, R. (author), Vlasblom, E. (author), Wit, J.M. (author), Beltman, M. (author)AIMS: To develop a guideline for preventive child healthcare (PCHC) professionals in order to improve early detection of pathological disorders associated with short stature (or growth faltering) or tall stature (or accelerated growth). Target groups include primary growth disorders (e.g. dysmorphic syndromes, such as Turner, Noonan, Prader...conference paper 2022
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van Dommelen, P. (author), van Buren, L.P. (author), Eekhout, I. (author), Verkerk, P.H. (author)AIMS: To identify key developmental milestones between 12-45 months in children requiring special education later in life. MATERIALS AND METHODS: Data on 36 milestones (gross and fine motor skills, adaptive/personal/social behavior, communication) from the Dutch Development Instrument, education type and background characteristics were obtained...conference paper 2022
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Theunissen, M. (author), de Wolff, M. (author), Klein Velderman, M. (author)Health risk behaviors, such as smoking, drug use, alcohol consumption, physical inactivity, and obesity, often accumulate during adolescence and are relatively persistent throughout the life course. Moreover, these can make youth vulnerable for developing consequent (mental) health problems. Community pediatric services (in the Netherlands...conference paper 2022
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Theunissen, M.H.C. (author), de Wilde, J.A. (author), Bezem, J. (author), van Harten, L. (author)Introduction. A uniform triage protocol is developed for Preventive Child Healthcare (PCH) to improve the quality of detection of health problems in primary school children by PCH. The aim of this study is to investigate 1) the psychometric properties and 2) satisfaction of PCH professionals of this uniform triage protocol. Methods. We included...article 2022
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Theunissen, M.H.C. (author), de Wolff, M.S. (author), Eekhout, I. (author), Mieloo, C.L. (author), Stone, L.L. (author), Reijneveld, S.A. (author)Objective: This study provides Dutch national norms for the parent-reported Strengths and Difficulties Questionnaire (SDQ) for children aged 3-14 years, and assesses the test performance of the SDQ Total Difficulties Scale (TDS) and impairment Scale. We further compared Dutch SDQ norms with those of the United Kingdom (UK), to determine...article 2022
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Tornincasa, V. (author), Dixon, V. (author), Le Masne, Q. (author), Martin, B. (author), Arnaud, L. (author), van Dommelen, P. (author), Koledova, E. (author)Digital health has seen rapid advancements over the last few years in helping patients and their healthcare professionals better manage treatment for a variety of illnesses, including growth hormone (GH) therapy for growth disorders in children and adolescents. For children and adolescents requiring such therapy, as well as for their parents,...article 2022
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van Bindsbergen, K.L.A. (author), van der Hoek, H. (author), Marloes van, (author), van Gorp, M. (author), Ligthart, M.E.U. (author), Hindriks, K.V. (author), Neerincx, M.A. (author), Alderliesten, T. (author), Bosman, P.A.N. (author), Merks, J.H.M. (author), Grootenhuis, M.A. (author), van Litsenburg, R.L. (author)Objectives: Children with cancer often experience sleep problems, which are associated with many negative physical and psychological health outcomes, as well as with a lower quality of life. Therefore, interventions are strongly required to improve sleep in this population. We evaluated interactive education with respect to sleep hygiene with a...article 2022
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Araujo, M. (author), van Dommelen, P. (author), Srivastava, J. (author), Koledova, E. (author)Recombinant human growth hormone (r-hGH) is an established therapy for growth hormone deficiency (GHD); yet, some patients fail to achieve their full height potential, with poor adherence and persistence with the prescribed regimen often a contributing factor. A data-driven clinical decision support system based on “traffic light” visualizations...article 2021
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Ligthart, M. (author), Neerincx, M.A. (author), Hindriks, K.V. (author)We are developing a social robot that should autonomously interact long-term with pediatric oncology patients. The child and the robot need to get acquainted with one another before a long-term interaction can take place. We designed five interaction design patterns and two sets of robot behaviors to structure a getting acquainted interaction....conference paper 2019
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Kaptein, F. (author), Broekens, J. (author), Hindriks, K. (author), Neerincx, M.A. (author)Explanation of actions is important for transparency of-, and trust in the decisions of smart systems. Literature suggests that emotions and emotion words - in addition to beliefs and goals - are used in human explanations of behaviour. Furthermore, research in e-health support systems and human-robot interaction stresses the need for studying...conference paper 2019
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Reducing stress by bonding with a social robot: Towards autonomous long-term child-robot interactionLigthart, M. (author), Hindriks, K. (author), Neerincx, M.A. (author)Pediatric oncology patients could benefit from bonding with a social robot and talking about their day in the hospital. With our research we aim to contribute to the development of a robot that is able to facilitate a child-robot bond autonomously and long-term. We propose to use robot-disclosure and a shared interaction history to create a...conference paper 2018
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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...article 2018
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Fieten, K.B. (author), Totté, J.E.E. (author), Levin, E. (author), Reyman, M. (author), Meijer, Y. (author), Schuren, F.H.J. (author), Pasmans, S.G.M.A. (author), Pasmans, S.G.M.A. (author)Background: Exposure to microbes may be important in the development of atopic disease. Atopic diseases have been associated with specific characteristics of the intestinal microbiome. The link between intestinal microbiota and food allergy has rarely been studied, and the gold standard for diagnosing food allergy (double-blind placebo...article 2018
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Rowen, D. (author), Mulhem, B. (author), Stevens, K. (author), Vermaire, J.H. (author)Objective This article presents the development of the Dutch value set for the Child Health Utility 9D, a pediatric preference-based measure of quality of life that can be used to generate quality-adjusted life-years. Methods A large online survey was conducted using a discrete choice experiment including a duration attribute with adult members...article 2018
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Scheerman, J.F.M. (author), van Loveren, C. (author), van Meijel, B. (author), Dusseldorp, E. (author), Wartewig, E. (author), Verrips, G.H.W. (author), Ket, J.C.F. (author), van Empelen, P. (author)Objectives. This systematic and meta-analytic review aimed to quantify the association of psychosocial correlates with oral hygiene behaviour among 9- to 19-year olds. Methods. A systematic search up to August 2015 was carried out using the following databases: PubMed, PsycInfo, Embase, CINAHL and Web of Science. If necessary, authors of studies...article 2016
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Duijster, D. (author), de Jong-Lenters, M. (author), de Ruiter, C. (author), Thijssen, J. (author), van Loveren, C. (author), Verrips, E. (author)Objectives The aim of this cross-sectional study was to investigate the relationship between parental and family-related factors and childhood dental caries in a sample of 5- to 6-year-old children of Dutch, Moroccan and Turkish origin. Furthermore, the relationship of parental and family-related factors with social class and ethnicity was...article 2015
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Stalman, S.E. (author), Hellinga, I. (author), van Dommelen, P. (author), Hennekam, R.C.M. (author), Saari, A. (author), Sankilampi, U. (author), Dunkel, L. (author), Wit, J.M. (author), Kamp, G.A. (author), Plötz, F.B. (author)Aims: To evaluate three guidelines for selecting short children for diagnostic workup in a general pediatric clinic. Methods: All patients (n = 131) aged 3.00-9.99 years who were referred for growth failure to a general pediatric clinic were evaluated for their medical history and growth and examined. All of them underwent the same standardized...article 2015
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Kamphuis, M. (author), van de Nieuwegiessen, A.I. (author), Span, P.M. (author)Background Dutch Youth health care is an easily accessible service where parents can ask for support for the healthy development of their children. The majority of the screenings and medical examinations show no abnormalities. Sometimes there is doubt about the severity of symptoms: the line between healthy variation and diseases or...article 2014
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Duijster, D. (author), Verrips, G.H.W. (author), van Loveren, C. (author)OBJECTIVES: This study investigated the relationship between family functioning and childhood dental caries. Further objectives were (i) to explore whether oral hygiene behaviours could account for a possible association between family functioning dimensions and childhood dental caries and (ii) to explore whether family functioning could mediate...article 2014