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End, C. (author), Bikker, F.J. (author), Renner, M. (author), Bergmann, G. (author), Lyer, S. (author), Blaich, S. (author), Hudler, M. (author), Helmke, B. (author), Gassler, N. (author), Autschbach, F. (author), Ligtenberg, A.J.M. (author), Benner, A. (author), Holmskov, U. (author), Schirmacher, P. (author), Nieuw Amerongen, A.V. (author), Rosenstiel, P. (author), Sina, C. (author), Franke, A. (author), Hafner, M. (author), Kioschis, P. (author), Schreiber, S. (author), Poustka, A. (author), Mollenhauer, J. (author)Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS-induced TLR4-mediated NF-kappaB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the molecular basis of its function...article 2009
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TNO Defensie en Veiligheid (author), Mohamoud, A.A. (author), Maris, M.G. (author)In this paper, an emotion classification system based on speech signals is presented. The classifier can identify the most common emotions, namely anger, neutral, happiness and fear. The algorithm computes a number of acoustic features which are fed into the classifier based on a pattern recognition approach. The classification system is of...conference paper 2008
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van Maanen, P.P. (author), Klos, T. (author), van Dongen, C.J. (author), TNO Defensie en Veiligheid (author)This paper involves a human-agent system in which there is an operator charged with a pattern recognition task, using an automated decision aid. The objective is to make this human-agent system operate as effectively as possible. Effectiveness is gained by an increase of appropriate reliance on the operator and the aid. We studied whether it is...conference paper 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.P.H.T.M. (author), Horbach, G.J. (author), Smit, M.J. (author), Zandberg, P. (author), Mellema, J.R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were administered at five single oral dosages between 2 and 500 mg/kg and between 6 and 1800 mg/kg,...article 2007
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Schoonen, W.G.E.J. (author), Kloks, C.P.A.M. (author), Ploemen, J.-P.H.T.M. (author), Smit, M.J. (author), Zandberg, P. (author), Horbach, G.J. (author), Mellema, J.-R. (author), van Zuylen, C.T. (author), Tas, A.C. (author), van Nesselrooij, J.H.J. (author), Vogels, J.T.W.E. (author), TNO Kwaliteit van Leven (author)A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference compounds and one nontoxic control compound (mianserine) in rats. The toxic compounds are...article 2007
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Engelen, L. (author), van den Keybus, P.A.M. (author), de Wijk, R.A. (author), Veerman, E.C.I. (author), Amerongen, A.V.N. (author), Bosman, F. (author), Prinz, J.F. (author), van der Bilt, A. (author), TNO Kwaliteit van Leven (author)Saliva is expected to be of significance for the perception of food stimuli in the mouth. Mixing the food with saliva, including breakdown and dilution, is considered to be of large importance for semi-solids as these products are masticated without chewing. It is known that there are large variations in composition of saliva originating from...article 2007
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Hartgers, F.C. (author), Smits, H.H. (author), van der Kleij, D. (author), Yazdanbakhsh, M. (author), TNO Defensie en Veiligheid (author)Helminth infections have profound effects on the immune system. Here, recent insights in the molecular interactions between schistosomes and the host are described with respect to adaptive but also with respect to innate immune responses. Furthermore, the different mechanisms of immune hyporesponsiveness are depicted with emphasis on regulatory...article 2006
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van Leeuwen, D.A. (author), Martin, A.F. (author), Przybocki, M.A. (author), Bouten, J.S. (author), TNO Defensie en Veiligheid (author)In the past years, several text-independent speaker recognition evaluation campaigns have taken place. This paper reports on results of the NIST evaluation of 2004 and the NFI-TNO forensic speaker recognition evaluation held in 2003, and reflects on the history of the evaluation campaigns. The effects of speech duration, training handsets,...article 2006
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van der Greef, J. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)Metabolomics is a growing area in the field of systems biology. Metabolomics has already a long history and also the connection of metabolomics with chemometrics goes back some time. This review discusses the symbiosis of metabolomics and chemometrics with emphasis on the medical domain, puts the combination of the two in historical perspective...article 2005
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TNO Kwaliteit van Leven TNO Voeding (author), Gibney, M.J. (author), Walsh, M. (author), Brennan, L. (author), Roche, H.M. (author), German, B. (author), van Ommen, B. (author)Metabolomics has been widely adopted in pharmacology and toxicology but is relatively new in human nutrition. The ultimate goal, to understand the effects of exogenous compounds on human metabolic regulation, is similar in all 3 fields. However, the application of metabolomics to nutritional research will be met with unique challenges. Little is...article 2005
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Montijn, R. (author), Schuren, F. (author), van Spek, H.D. (author), Keijser, B. (author), Brul, S. (author), TNO Voeding (author)The development of genomics technologies for guiding the predictive modeling of microorganism behavior to make food preservation treatments effective, are discussed. A fully genomewide description of cellular response to environmental conditions lies in the combination of a transcriptome and proteome/metabolome analysis. The predictive models...article 2004
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Rodríguez-Sánchez, R. (author), Fdez-Valdivia, J. (author), Toet, A. (author), García, J.A. (author), TNO Technische Menskunde (author)The goal of this paper is to analyze the relation between the visual distinctness and the priority assigned to the information in two di2erent progressive transmission schemes: the Set Partitioning in Hierarchical Trees (SPIHT) and the Rational Embedded Wavelet Image Coding (REWIC). SPIHT assigns priority based on the mean squared-error (MSE)...article 2004
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'T Hart, B.A. (author), Vogels, J. (author), Bauer, J. (author), Brok, H.P.M. (author), Blezer, E. (author), TNO Voeding (author)Early recognition of whether a product has potential as a new therapy for treating multiple sclerosis (MS) relies upon the quality of the animal models used in the preclinical trials. The promising effects of new treatments in rodent models of experimental autoimmune encephalomyelitis (EAE) have rarely been reproduced in patients suffering from...article 2004
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Milisavljević, N. (author), Bloch, I. (author), van den Broek, S.P. (author), Acheroy, M. (author), TNO Fysisch en Elektronisch Laboratorium (author)A methodfor modeling andcombination of measures extractedfrom a ground-penetrating radar (GPR) in terms of belief functions within the Dempster-Shafer framework is presentedandillustratedon a real GPR data set. A starting point in the analysis is a preprocessed C-scan of a sand-lane containing some mines andfalse alarms. In order to improve the...article 2003
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't Hart, B.A. (author), Vogels, J.T.W.E. (author), Spijksma, G. (author), Brok, H.P.M. (author), Polman, C. (author), van der Greef, J. (author), Primatencentrum TNO (author)Proton nuclear magnetic resonance (1H-NMR) spectroscopy in combination with pattern recognition techniques were used to investigate the composition of organic compounds in urines from patients with multiple sclerosis (MS), patients with other neurological diseases (OND) and healthy controls (H). Using a valid animal model of MS, namely the...article 2003
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Feron, V.J. (author), Cassee, F.R. (author), Groten, J.P. (author), van Vliet, P.W. (author), van Zorge, J.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)In this article, we highlight new developments and recent studies concerning adverse human health effects related to chemical mixtures. One group of activities comprises the development of a new computer program for analyzing mixture studies and a mathematical model as a basis for combination rules that predict the toxicity of mixtures. Other...article 2002
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Schavemaker, J.G.M. (author), Reinders, M.J.T. (author), Gerbrands, J.J. (author), Backer, E. (author), TNO Fysisch en Elektronisch Laboratorium (author)This paper introduces a class of iterative morphological image operators with applications to sharpen digitized gray-scale images. It is proved that all image operators using a concave structuring function have sharpening properties. By using a Laplacian property, we introduce the underlying partial differential equation that governs this class...article 2001
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van der Werf, M.J. (author), Schuren, F.H.J. (author), Bijlsma, S. (author), Tas, A.C. (author), van Ommen, B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The holistic study of the keystone biomolecules by applied genomics is one of the intellectual products of the current molecular biology revolution. These applied genomics technologies (transcriptomics, proteomics, and metabolomics) aim at analyzing the components of a cell in its entirety and have, together with the developments in computing,...article 2001
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Manniesing, R. (author), Karkowski, I.P. (author), Corporaal, H. (author), TNO Fysisch en Elektronisch Laboratorium (author)This paper investigates the potential for automatic mapping of typical embedded applications to architectures with multimedia instruction set extensions. For this purpose a (pattern matching based) code transformation engine is used, which involves a three-step process of matching, condition checking and replacing of the source code. Experiments...bookPart 2000
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Theeuwes, J. (author), Kramer, A.F. (author), Hahn, S. (author)Previous research has shown that when searching for a color singleton. top-down control cannot prevent attentional capture by an abrupt visual onset. The present research addressed whether a task-irrelevant abrupt onset would affect eye movement behavior when searching for a color singleton. Results show that in many instances the eye moved in...article 1999