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Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...article 2014
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Beker van Woudenberg, A. (author), Snel, C. (author), Rijkmans, E. (author), de Groot, D. (author), Bouma, M. (author), Hermsen, S. (author), Piersma, A. (author), Menke, A. (author), Wolterbeek, A. (author)To improve the predictability of the zebrafish embryotoxicity test (ZET) for developmental (neuro)toxicity screening, we used a multiple-endpoints strategy, including morphology, motor activity (MA), histopathology and kinetics. The model compounds used were antiepileptic drugs (AEDs): valproic acid (VPA), carbamazepine (CBZ), ethosuximide (ETH)...article 2014
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Bakker, L.E.H. (author), Boon, M.R. (author), van der Linden, R.A.D. (author), Arias-Bouda, L.P. (author), van Klinken, J.B. (author), Smit, F. (author), Verberne, H.J. (author), Jukema, J.W. (author), Tamsma, J.T. (author), Havekes, L.M. (author), van Marken Lichtenbelt, W.D. (author), Jazet, I.M. (author), Rensen, P.C.N. (author)Background: Individuals of south Asian origin have a very high risk of developing type 2 diabetes compared with white Caucasians. We aimed to assess volume and activity of brown adipose tissue (BAT), which is thought to have a role in energy metabolism by combusting fatty acids and glucose to produce heat and might contribute to the difference...article 2014
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Cramp, A.J. (author), van den Berg, T.W. (author), Huiskamp, W. (author)Performance assessment is a key factor in designing distributed simulation environments that are fit-forpurpose and cost-effective. Simulations used for training applications should provide the required level of responsiveness and interactivity. Simulations used for analysis or decision support should execute as fast as possible to enable quick...conference paper 2014
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ten Thij, M. (author), Ouboter, T.M. (author), Worm, D.T.H. (author), Litvak, N. (author), van den Berg, J.L. (author), Bhulai, S. (author)In this paper we model user behaviour in Twitter to capture the emergence of trending topics. For this purpose, we first extensively analyse tweet datasets of several different events. In particular, for these datasets, we construct and investigate the retweet graphs. We find that the retweet graph for a trending topic has a relatively dense...bookPart 2014
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van Eekeren, A.W.M. (author), Dijk, J. (author), Schutte, K. (author)In general, long range detection, recognition and identification in visual and infrared imagery are hampered by turbulence caused by atmospheric conditions. The amount of turbulence is often indicated by the refractive-index structure parameter Cn 2. The value of this parameter and its variation is determined by the turbulence effects over the...conference paper 2014
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Joosten, M.M. (author), Schrieks, I.C. (author), Hendriks, H.F.J. (author)Background: Fetuin-A, a liver-derived glycoprotein that impairs insulin-signalling, has emerged as a biomarker for diabetes risk. Although moderate alcohol consumption has been inversely associated with fetuin-A, data from clinical trials are lacking. Thus, we evaluated whether moderate alcohol consumption decreases circulating levels of fetuin...article 2014
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Klein Entink, R.H. (author), Remington, B.C. (author), Blom, W.M. (author), Rubingh, C.M. (author), Kruizinga, A.G. (author), Baumert, J.L. (author), Taylor, S.L. (author), Houben, G.F. (author)For most allergenic foods, limited availability of threshold dose information within the population restricts the advice on action levels of unintended allergenic foods which should trigger advisory labeling on packaged foods.The objective of this paper is to provide guidance for selecting an optimal sample size for threshold dosing studies for...article 2014
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Fokker, P.A. (author), van Wees, J.D. (author)We investigated the impact of the exploitation of a geothermal well doublet on surface movement. We found that the largest effect should be expected from the progressive cooling of the reservoir, through the thermo-elastic coupling. The absolute value of the expected subsidence is low, but possibly measureable if circumstances are favourite. In...conference paper 2014
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Zimmer, B. (author), Pallocca, G. (author), Dreser, N. (author), Foerster, S. (author), Waldmann, T. (author), Westerhout, J. (author), Julien, S. (author), Krause, K.H. (author), van Thriel, C. (author), Hengstler, J.G. (author), Sachinidis, A. (author), Bosgra, S. (author), Leist, M. (author)Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel alternative tests project, we developed a test battery framework that allows inclusion of any developmental toxicity assay and that explores the responses of such test...article 2014
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Heyer, A. (author), D'Souza, F. (author), Morales, C.F.L. (author), Ferrari, G. (author), Mol, J.M.C. (author), de Wit, J.H.W. (author)Microbiologically Influenced Corrosion (MIC) is the term used for the phenomenon in which corrosion is initiated and/or accelerated by the activities of microorganisms. MIC is a very serious problem for the ship industry as it reduces structural lifetime in combination with safety risks for crewmembers or inspection personal and increases...article 2013
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Vellvehi, M. (author), Perpina, X. (author), Jorda, X. (author), Werkhoven, R.J. (author), Kunen, J.M.G. (author), Jakovenko, J. (author), Bancken, P. (author), Bolt, P.J. (author)This work deals with the extraction of key thermal parameters for accurate thermal modelling of LED lamps: air exchange coefficient around the lamp, emissivity and thermal conductivity of all lamp parts. As a case study, an 8W retrofit lamp is presented. To assess simulation results, temperature is monitored on the lamp by infrared thermography...conference paper 2013
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van Riet, M.W.G. (author), van de Pol, J. (author), van der Zwan, T. (author)Underwater acoustic modeling is used in many fields of research and development, which has resulted in a wide variety of acoustic models and applications, such as sensor performance prediction, sensor performance optimizations and acoustic impact on marine life. Many of the applications share a similar set of input parameters: bathymetry, sound...conference paper 2013
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Rubingh, C.M. (author), Martens, H. (author), van der Voet, H. (author), Smilde, A.K. (author)Each data-driven action in data modelling consumes degrees of freedom, whether it concerns estimation of parameters, estimation of meta-parameters or selecting variables. By using a double cross validation approach for degrees of freedom calculation the costs for meta-parameter estimation and variable selection can be determined explicitly. The...article 2013
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van Wees, J.D. (author), Neele, F. (author)Geothermal Energy and CO2 Capture and Storage (CCS) are both considered major contributors to the global energy transition. Their success critically depends on subsurface resource quality, which in turn depends on specific subsurface parameters. For CCS and Geothermal Energy these in some respect overlap and others differ. Here, an overview is...conference paper 2013
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Wolterbeek, A.P.M. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Piersma, A.H. (author), van Loveren, H. (author)The susceptibility of developing immune system to chemical disruption warrants the assessment of immune parameters in reproductive and developmental testing protocols. In this study, a wide range of immune endpoints was included in an extended one-generation reproduction toxicity study (EOGRTS) design to determine the relative sensitivity of...article 2013
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Koenen, M. (author), Wasch, L.J. (author)Many uncertainties exist in geochemical modeling. Mineral reactive surface area is one of the uncertain parameters. QEMSCAN analyses are performed on sandstone samples from a Dutch CO2 natural analogue to determine reactive surface areas. Geochemical modeling is performed using QEMSCAN surface areas and surface areas which are conventionally...conference paper 2013
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Wilson, C. (author), van Eijk, A.M.J. (author), Fedorovich, E. (author)A methodology is presented to infer the refractive-index structure function parameter and the structure parameters for temperature and humidity from numerical simulations of the turbulent atmospheric convective boundary layer (CBL). The method employs spatial and temporal averaging of multiple realizations of the CBL flow field reproduced by a...conference paper 2013
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Li, M. (author), Stingelin, N. (author), Michels, J.J. (author), Spijkman, M.-J. (author), Asadi, K. (author), Beerends, R. (author), Biscarini, F. (author), Blom, P.W.M. (author), de Leeuw, D.M. (author)The processing of solution-based binary blends of the ferroelectric random copolymer poly(vinylidene fluoride-trifluoroethylene) P(VDF-TrFE) and the semiconducting polymer poly(9,9-dioctylfluorenyl-2,7-diyl) (PFO) applied by spin-coating and wire-bar coating is investigated. By systematic variation of blend composition, solvent, and deposition...article 2012
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van Kersbergen, M.J. (author), Beerkens, R.G.C. (author), Sarmiento-Darkin, W. (author), Kobayashi, H. (author)The energy efficiency performance, production stability and emissions of oxygen-fired glass furnaces are influenced by the type of burner, burner nozzle sizes, burner positions, burner settings, oxygen-gas ratios and the fuel distribution among all the burners. These parameters have been optimized for a 300 tpd (metric tons per day glass pull)...conference paper 2012