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Botschuijver, S. (author), Roeselers, G. (author), Levin, E. (author), Jonkers, D.M. (author), Welting, O. (author), Heinsbroek, S.E.M. (author), de Weerd, H.H. (author), Boekhout, T. (author), Fornai, M. (author), Masclee, A.A. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), Seppen, J. (author), van den Wijngaard, R.M. (author)Background & Aims Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in the activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the fungal microbiome) in the development of IBS. We analyzed intestinal mycobiomes of patients with...article 2017
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Steenstra, I.A. (author), Knol, D.L. (author), Bongers, P.M. (author), Anema, J.R. (author), van Mechelen, W. (author), de Vet, H.C.W. (author), TNO Kwaliteit van Leven (author)STUDY DESIGN. Exploratory subgroup analysis in a randomized controlled trial (RCT). OBJECTIVE. To detect possible moderators in the effectiveness of a workplace intervention in a population of workers with sick leave due to sub acute nonspecific low back pain. SUMMARY OF BACKGROUND DATA. In a recently published RCT, a workplace intervention was...article 2009
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Steenstra, I.A. (author), Anema, J.R. (author), Bongers, P.M. (author), de Vet, H.C.W. (author), Knol, D.L. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)A controlled trial was performed in a occupational healthcare setting to determine the effectiveness of graded activity as part of a multistage RTW programme. Workers (112) absent from work for more than eight weeks due to low back pain, were randomised to either graded activity (n = 55) or usual care (n = 57). The graded activity, a physical...article 2006
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Heymans, M.W. (author), de Vet, H.C.W. (author), Bongers, P.M. (author), Knol, D.L. (author), Koes, B.W. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)Study Design. Randomized controlled trial. Objectives. To compare high- and low-intensity back schools with usual care in occupational health care. Summary of Background Data. The content and intensity of back schools vary widely and the methodologic quality of randomized controlled trials is generally weak. Until now, no back school has proven...article 2006
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Heuts, P.H.T.G. (author), de Bie, R. (author), Drietelaar, M. (author), Aretz, K. (author), Hopman-Rock, M. (author), Bastiaenen, C.H.G. (author), Metsemakers, J.F.M. (author), van Weel, C. (author), van Schayck, O.C.P. (author), TNO Preventie en Gezondheid (author)Objective. To assess in a primary healthcare setting the efficacy of a self-management program in middle-aged patients with osteoarthritis (OA). Methods. This was a 2-group randomized controlled trial, with 273 patients aged 40 to 60 years with OA of the hip(s) and/or knee(s). The experimental intervention was compared with care-as-usual....article 2005
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van den Heuvel, S.G. (author), Heinrich, J. (author), Jans, M.P. (author), van der Beek, A.J. (author), Bongers, P.M. (author), TNO Kwaliteit van Leven (author)Background. Little is known of the preventive effects of physical activity in leisure time on neck and upper limb symptoms. Methods. A cohort of 1742 employees was selected from a prospective cohort study with a follow-up period of 3 years. Independent variables were sporting activities and physically active commuting. Outcome measures were neck...article 2005
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Raat, H. (author), Bonsel, G.J. (author), Hoogeveen, W.C. (author), Essink-Bot, M.L. (author), Gemke, R.J.B.J. (author), Krabbe, P.F.M. (author), Moll, H.A. (author), Suijlekom van-Smit, L.W.A. (author), Verrips, E. (author), TNO Preventie en Gezondheid (author)To establish the generalizability (external validity) of the Health Utilities Index Mark 3 (HUI3) as a single-summary score generic outcome measure in numerous countries/subgroups (including children), repeated studies of community preferences should be performed in various settings. In performing multiple HUI3 studies, a mailed questionnaire...article 2004
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TNO Preventie en Gezondheid (author), Boonen, A. (author), van der Heijde, D. (author), Landewé, R. (author), Chorus, A. (author), van Lankveld, W. (author), Miedema, H. (author), van der Tempel, H. (author), van der Linden, S. (author)Objective: To determine whether avoidant coping in ankylosing spondylitis (AS) is independent of disease status and whether it is stable over time. Methods: 658 patients with AS completed a postal questionnaire on health status, including pain and stiffness (BASDAI), physical function (BASFI), and coping (CORS). In CORS, "decreasing activities...article 2004
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Peters, J.W.B. (author), Koot, H.M. (author), Grunau, R.E. (author), de Boer, J. (author), van Druenen, M.J. (author), Tibboel, D. (author), Duivenvoorden, H.J. (author), TNO Preventie en Gezondheid (author)Objective: The objectives of this study were to: (1) evaluate the validity of the Neonatal Facial Coding System (NFCS) for assessment of postoperative pain and (2) explore whether the number of NFCS facial actions could be reduced for assessing postoperative pain. Design: Prospective, observational study. Patients: Thirty-seven children (0-18...article 2003
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TNO Arbeid (author), van den Heuvel, S.G. (author), de Looze, M.P. (author), Hildebrandt, V.H. (author), Thé, K.H. (author)Objectives. This study evaluated the effects on work-related neck and upper-limb disorders among computer workers stimulated (by a software program) to take regular breaks and perform physical exercises. Possible effects on sick leave and productivity were studied as well. Methods. A randomized controlled design was used with cluster...article 2003
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TNO Preventie en Gezondheid (author), Peters, J.W.B. (author), Koot, H.M. (author), Boer, J.B.de (author), Passchier, J. (author), Bueno de Mesquita, J.M. (author), Jong, F.H.de (author), Duivenvoorden, H.J. (author), Tibboel, D. (author)Objectives. Pain exposure during early infancy affects the pain perception beyond infancy into childhood. The objective of this study was to examine whether major surgery within the first 3 months of life in combination with preemptive analgesia alters pain responses to immunization at 14 or 45 months and to assess whether these alterations are...article 2003
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van der Laan, W. (author), Molenaar, E. (author), Ronday, K. (author), Verheijen, J. (author), Breedveld, F. (author), Greenwald, R. (author), Dijkmans, B. (author), Tekoppele, J. (author), Gaubius instituut TNO (author)Objective. To investigate the effects of doxycycline on disease activity and joint destruction in patients with rheumatoid arthritis (RA). Methods. A 36 week double blind, placebo controlled crossover trial was conducted. Patients (n = 66) received 50 mg doxycycline or placebo twice a day during 12, 24, or 36 weeks. Patient assessments were...article 2001
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van Buuren, S. (author), Hopman-Rock, M. (author), TNO Preventie en Gezondheid (author)The Severity of Disabilities Scale (SDS) of the ICIDH reflects the degree to which an individual's ability to perform a certain activity is restricted. This paper describes the application of two models from item response theory (IRT), the graded response model and the partial credit model, in order to derive a tentative proposal for a revised...article 2001
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Hildebrandt, V.H. (author), Proper, K.I. (author), van den Berg, R. (author), Douwes, M. (author), van den Heuvel, S.G. (author), van Buuren, S. (author), TNO Preventie en Gezondheid (author)Objective. To determine the effectiveness of a special form of exercise therapy ('Cesar therapy') on self reported recovery and improvement of posture amongst patients with chronic aspecific lower back pain. Design. Prospective randomized controlled and blinded investigation. Method. After informed consent had been obtained, patients with...article 2000
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Hopman-Rock, M. (author), Westhoff, M.H. (author), TNO Preventie en Gezondheid (author)Objective. Evaluation of a self-management program for patients with osteoarthritis (OA) of the hip or knee. The program, which consisted of 6 weekly sessions of 2 hours, included health education by a peer and physical exercises taught by a physical therapist. Methods. Randomized controlled trial. Inclusion criteria were diagnosis of OA of the...article 2000
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TNO Preventie en Gezondheid (author), Janssen, H.A.M. (author), Borghouts, J.A.J. (author), Muris, J.W.M. (author), Metsemakers, J.F.M. (author), Koes, B.W. (author), Knottnerus, J.A. (author)Background. While chronic non-specific abdominal complaints are common in general practice, data on patients' perspective and management of these complaints are lacking. Knowledge of these data is important for the development of guidelines for management and assessment of the burden of chronic non-specific abdominal complaints on society. Aim....article 2000
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Hopman-Rock, M. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)This study examines the quality of life (QOL) of community living elderly people aged 55-74 with chronic, episodic or sporadic pain in the hip or knee and of a reference group without pain (total n = 306). Firstly, it was hypothesized that the experienced QOL is lower in people with more chronic pain. Secondly, the potential mediating and...article 1997
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Hopman-Rock, M. (author), Odding, E. (author), Hofman, A. (author), Kraaimaat, F.W. (author), Bijlsma, J.W.J. (author), TNO Preventie en Gezondheid (author)Objective. To determine physical and psychosocial disability in subjects aged 55 to 74 years living in the community, in relation to pain in the hip and/or knee, and to explore the relationships between pain, physical and psychosocial disability, and selected background variables. Methods. A subsample from a community based study on pain,...article 1996
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Havenith, G. (author), van de Linde, E.J.G. (author), Heus, R. (author)Hand cooling and resulting comfort and pain were studied in 12 subjects, while touching six different materials (polyurethane foam, wood, nylon, rustproof steel, aluminium, and temperature-controlled metal) which were initially at ambient temperature. This was done for three ambient temperatures (-10°, 0° and 10°C), after pre-exposure exercise...article 1992