Searched for: subject%3A%22PHS%255C%2B%255C-%255C%2BPharmacokinetics%255C%2B%2526%255C%2BHuman%255C%2BStudies%22
(81 - 100 of 108)
- document
-
Kleemann, R. (author), Bureeva, S. (author), Perlina, A. (author), Kaput, J. (author), Verschuren, L. (author), Wielinga, P.Y. (author), Hurt-Camejo, E. (author), Nikolsky, Y. (author), van Ommen, B. (author), Kooistra, T. (author)Successful drug development has been hampered by a limited understanding of how to translate laboratory-based biological discoveries into safe and effective medicines. We have developed a generic method for predicting the effects of drugs on biological processes. Information derived from the chemical structure and experimental omics data from...article 2011
- document
-
Mateo Anson, N. (author), Aura, A.-M. (author), Selinheimo, E. (author), Mattila, I. (author), Poutanen, K. (author), van den Berg, R. (author), Havenaar, R. (author), Bast, A. (author), Haenen, G.R.M.M. (author)Whole grain consumption has been linked to a lower risk of metabolic syndrome, which is normally associated with a lowgrade chronic inflammation. The benefits of whole grain are in part related to the inclusion of the bran, rich in phenolic acids and fiber. However, the phenols are poorly bioaccessible from the cereal matrix. The aim of the...article 2011
- document
-
Havenaar, R. (author)This review tries to find a scientific answer on the following two questions: (1) to what extent do we understand the specific role of colonic microbial metabolites, especially short-chain fatty acids (SCFA), in maintaining the health status and prevention of diseases of the colon and the host; (2) to what extent can we influence or even control...article 2011
- document
-
Gubbels, J.S. (author), Thijs, C. (author), Stafleu, A. (author), van Buuren, S. (author), Kremers, S.P.J. (author)Objectives. The mechanisms underlying the protective effect of breast-feeding on the development of childhood overweight are unclear. This study examines the association of breast-feeding with weight gain in the first year, and body mass index (BMI) and overweight up to 4 years. In addition, we examine possible mechanisms of this effect (i.e.,...article 2011
- document
-
Mateo Anson, N. (author), Havenaar, R. (author), Vaes, W. (author), Coulier, L. (author), Venema, K. (author), Selinheimo, E. (author), Bast, A. (author), Haenen, G.R.M.M. (author)The health benefits of whole grain consumption can be partly attributed to the inclusion of the bran or outer-layers of the grain rich in dietary fibre. Fibre is fermented in the colon, leading to the production of beneficial metabolites, such as short-chain fatty acids (SCFA). The effect of five different types of bread on the SCFA production...article 2011
- document
-
Vlaming, M.L.H. (author), van Esch, A. (author), van de Steeg, E. (author), Pala, Z. (author), Wagenaar, E. (author), van Tellingen, O. (author), Schinkel, A.H. (author)The ATP-binding cassette (ABC) transporters ABCC2 [multidrug resistance-associated protein (MRP) 2], ABCC3 (MRP3), and ABCG2 (breast cancer resistance protein) are involved in the efflux of potentially toxic compounds from the body. We have shown before that ABCC2, ABCC3, and ABCG2 together influence the pharmacokinetics of the anticancer and...article 2011
- document
- Zhu, Y. (author), Havenaar, R. (author), Venema, K. (author) article 2011
- document
-
Zuurmond, A.M. (author), Koudijs, A. (author), van El, B. (author), Doornbos, R.P. (author), van Manen-Vernooij, B.C.T. (author), Bastiaans, J.H.M.W. (author), Penninks, A.H. (author), van Bilsen, J.H.M. (author), Cnubben, N.H.P. (author), de Groot, J. (author)Pharmacokinetic properties and safety profile of a drug are likely influenced by the disease state of a patient. In this study, we investigated the influence of arthritic processes on pharmacokinetics and immunotoxicity of interleukin-1 receptor antagonist (Anakinra) in the rat adjuvant arthritis model. Anakinra dose-dependently suppressed joint...article 2011
- document
- Venema, K. (author) article 2011
- document
-
van den Berg, E. (author), Hospers, F.A.P. (author), Navis, G. (author), Engberink, M.F. (author), Brink, E.J. (author), Geleijnse, J.M. (author), van Baak, M.A. (author), Gans, R.O.B. (author), Bakker, S.J.L. (author)Diabetic nephropathy is now the most common cause of end-stage renal failure in many countries of the world. Despite increasing implementation of preventive treatment, the chance that an individual diabetic patient will reach end-stage renal failure has been increasing rather than decreasing during recent decades. Current dietary habits in The...article 2011
- document
-
Joosen, M.J.A. (author), van der Schans, M.J. (author), van Dijk, C.G.M. (author), Kuijpers, W.C. (author), Wortelboer, H.M. (author), van Helden, H.P.M. (author)One of the shortcomings of current treatment of nerve agent poisoning is that oximes hardly penetrate the blood-brain barrier (BBB), whereas nerve agents easily do. Increasing the concentration of oximes in the brain, would therefore provide an attractive approach to improve medical countermeasures. An explanation for limited penetration might...article 2011
- document
-
Louisse, J. (author), Gönen, S. (author), Rietjens, I.M.C.M. (author), Verwei, M. (author)The present study determines the relative developmental toxicity potencies of retinoids in the embryonic stem (ES)-D3 cell differentiation assay of the embryonic stem cell test, and compares the outcomes with their relative potencies in in vivo and two other in vitro assays for developmental toxicity. The results reveal that the potency ranking...article 2011
- document
- Al-Moniee, M. (author), Koopal, C. (author), Akmal, N. (author), van Veen, J.J.F. (author), Saunders, P. (author) conference paper 2011
- document
- Dutman, A.E. (author), Stafleu, A. (author), Kruizinga, A. (author), Brants, H.A. (author), Westerterp, K.R. (author), Kistemaker, C. (author), Meuling, W.J. (author), Goldbohm, R.A. (author) article 2011
- document
-
Joosten, M.M. (author), Chiuve, S.E. (author), Mukamal, K.J. (author), Hu, F.B. (author), Hendriks, H.F. (author), Rimm, E.B. (author)OBJECTIVE: The objective of this study was to investigate the association of 4-year changes in alcohol consumption with a subsequent risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: We prospectively examined 38,031 men from the Health Professionals Follow-Up Study who were free of diagnosed diabetes or cancer in 1990. Alcohol consumption...article 2011
- document
-
Joosten, M.M. (author), Witkamp, R.F. (author), Hendriks, H.F.J. (author)Moderate alcohol consumption is associated with increased concentrations of adiponectin. Whether this is the case for both total and high-molecular-weight (HMW) adiponectin is uncertain. Furthermore, the rate at which this increase occurs is unclear. Therefore, we examined the effect of moderate alcohol consumption on total and HMW adiponectin....article 2011
- document
-
Gubbels, J.S. (author), Kremers, S.P.J. (author), Stafleu, A. (author), de Vries, S.I. (author), Goldbohm, R.A. (author), Dagnelie, P.C. (author), de Vries, N.K. (author), van Buuren, S. (author), Thijs, C. (author)Background: Insights into the effects of energy balance-related parenting practices on children’s diet and activity behavior at an early age is warranted to determine which practices should be recommended and to whom. The purpose of this study was to examine child and parent background correlates of energy balance-related parenting practices at...article 2011
- document
-
Welch, R.W. (author), Antoine, J.M. (author), Berta, J.L. (author), Bub, A. (author), Vries, J.de (author), Guarner, F. (author), Hasselwander, O. (author), Hendriks, H. (author), Jäkel, M. (author), Koletzko, B.V. (author), Patterson, C.C. (author), Richelle, M. (author), Skarp, M. (author), Theis, S. (author), Vidry, S. (author), Woodside, J.V. (author)There is substantial evidence to link what we eat to the reduction of the risk of major chronic diseases and/or the improvement of functions. Thus, it is important for public health agencies and the food industry to facilitate the consumption of foods with particular health benefits by providing consumer products and messages based on scientific...article 2011
- document
-
Eating behaviour and retro-nasal aroma release in normal-weight and overweight adults: A pilot studyZijlstra, N. (author), Bukman, A.J. (author), Mars, M. (author), Stafleu, A. (author), Ruijschop, R.M.A.J. (author), de Graaf, C. (author)Eating rate and bite size are important factors affecting food intake, and we hypothesise the underlying role of oral sensory exposure in this. However, the latter currently lacks objective measuring parameters, but an interesting measure could be the extent of in vivo retro-nasal aroma release. Second, the literature is ambiguous about...article 2011
- document
-
Rubingh, C.M. (author), van Erk, M.J. (author), Wopereis, S. (author), van Vliet, T. (author), Verheij, E.R. (author), Cnubben, N.H.P. (author), van Ommen, B. (author), van der Greef, J. (author), Hendriks, H.F.J. (author), Smilde, A.K. (author)Many benefits can be gained if multi-factorial diseases with a high incidence and prevalence are better understood. Sophisticated approaches like multilevel analyses are needed to discover subtle differences between healthy people and people at the onset of disease in these types of studies. Multilevel analysis generates different sub-models for...article 2011
Searched for: subject%3A%22PHS%255C%2B%255C-%255C%2BPharmacokinetics%255C%2B%2526%255C%2BHuman%255C%2BStudies%22
(81 - 100 of 108)