Searched for: subject%3A%22PHS%255C%2B%255C-%255C%2BPharmacokinetics%255C%2B%2526%255C%2BHuman%255C%2BStudies%22
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Wei, H. (author), Pasman, W. (author), Rubingh, C. (author), Wopereis, S. (author), Tienstra, M. (author), Schroen, J. (author), Wang, M. (author), Verheij, E. (author), van der Greef, J. (author)The prevalence of type 2 diabetes continuously increases globally. A personalized strategy applied in the pre-diabetic stage is vital for diabetic prevention and management. The personalized diagnosis of Chinese Medicine (CM) may help to stratify the diabetics. Metabolomics is regarded as a potential platform to provide biomarkers for disease...article 2012
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Al-Lahham, S. (author), Roelofsen, H. (author), Rezaee, F. (author), Weening, D. (author), Hoek, A. (author), Vonk, R. (author), Venema, K. (author)Background Adipose tissue is a primary site of obesity-induced inflammation, which is emerging as an important contributor to obesity-related diseases such as type 2 diabetes. Dietary fibre consumption appears to be protective. Short-chain fatty acids, e.g. propionic acid, are the principal products of the colonic fermentation of dietary fibre...article 2012
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Maathuis, A.J.H. (author), van den Heuvel, E.G. (author), Schoterman, M.H.C. (author), Venema, K. (author)Galacto-oligosaccharides (GOS) are considered to be prebiotic, although the contribution of specific members of the microbiota to GOS fermentation and the exact microbial metabolites that are produced upon GOS fermentation are largely unknown. We aimed to determine this using uniformly 13C-labeled GOS. The normal (control) medium and unlabeled...article 2012
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Hatanaka, M. (author), Nakamura, Y. (author), Maathuis, A.J.H. (author), Venema, K. (author), Murota, I. (author), Yamamoto, N. (author)Survival and germination rate of Bacillus subtilis C-3102 spores were investigated in a stomach and small intestine model (TIM-1), while the impact of C-3102 cells that had passed through TIM-1 on human colon microbiota was evaluated in a model of the large intestine (TIM-2). The survival of C-3102 spores in TIM-1 was 99%; 8% of the spores had...article 2012
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Voortman, T. (author), Hendriks, H.F.J. (author), Witkamp, R.F. (author), Wortelboer, H.M. (author)Gastrointestinal (GI) peptide hormones play an important role in short-term regulation of food intake and blood glucose levels. Modulating their release is of potential relevance for weight management and possibly diabetes. As currently available models are hard to extrapolate to the human situation, the use of porcine intestinal tissue,...article 2012
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Teunissen-Beekman, K.F.M. (author), Dopheide, J. (author), Geleijnse, J.M. (author), Bakker, S.J.L. (author), Brink, E.J. (author), de Leeuw, P.W. (author), van Baak, M.A. (author)Background: Dietary protein intake may help to manage blood pressure (BP) and prevent complications associated with elevated BP. Objective: The objective of this study was to determine whether 4 wk of increased protein intake (∼25% compared with ;15% of energy intake that isoenergetically replaces carbohydrate intake) lowers office and daytime...article 2012
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Wopereis, S. (author), Radonjic, M. (author), Rubingh, C. (author), van Erk, M. (author), Smilde, A. (author), van Duyvenvoorde, W. (author), Cnubben, N. (author), Kooistra, T. (author), van Ommen, B. (author), Kleemann, R. (author)The prevalence of diabetes mellitus Type 2 could be significantly reduced by early identification of subjects at risk, allowing for better prevention and earlier treatment. Glucose intolerance (GI) is a hallmark of the prediabetic stage. This study aims at identifying 1) prognostic biomarkers predicting the risk of developing GI later in life...article 2012
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Abrahamse, E. (author), Minekus, M. (author), van Aken, G.A. (author), van de Heijning, B. (author), Knol, J. (author), Bartke, N. (author), Oozeer, R. (author), van der Beek, E.M. (author), Ludwig, T. (author)At least during the first 6 months after birth, the nutrition of infants should ideally consist of human milk which provides 40-60 % of energy from lipids. Beyond energy, human milk also delivers lipids with a specific functionality, such as essential fatty acids (FA), phospholipids, and cholesterol. Healthy development, especially of the...article 2012
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van de Steeg, E. (author), Stránecký, V. (author), Hartmannová, H. (author), Nosková, L. (author), Hrebícek, M. (author), Wagenaar, E. (author), van Esch, A. (author), de Waart, D.R. (author), Oude Elferink, R.P.J. (author), Kenworthy, K.E. (author), Sticová, E. (author), Al-Edreesi, M. (author), Knisely, A.S. (author), Kmoch, S. (author), Milan Jirsa, M. (author), Schinkel, A.H. (author)Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The mechanistic basis of bilirubin excretion and hyperbilirubinemia syndromes is largely understood, but that of Rotor syndrome, an...article 2012
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Meijerink, M. (author), Wells, J. (author), Taverne, N. (author), de Zeeuw Brouwer, M.L. (author), Hilhorst, B. (author), Venema, K. (author), van Bilsen, J. (author)Peanut allergy accounts for the majority of severe food-related allergic reactions and there is a need for new prevention and treatment strategies. Probiotics may be considered for treatment on the basis of their immunomodulating properties. Cytokine profiles of probiotic strains were determined by in vitro co-culture with human PBMCs. Three...article 2012
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Engberink, M.F. (author), Bakker, S.J.L. (author), Brink, E.J. (author), van Baak, M.A. (author), van Rooij, F.J.A. (author), Hofman, A. (author), Witteman, J.C.M. (author), Geleijnse, J.M. (author)Background: Mild metabolic acidosis, which can be caused by diet, may result in elevated blood pressure (BP). Objective: The objective was to examine whether dietary acid load was associated with incident hypertension in a cohort of older Dutch adults from the Rotterdam Study. Design: The analyses included 2241 participants aged ≥55 y who were...article 2012
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- Visscher, T.L.S. (author), Nicolaou, M. (author), Pasman, W.J. (author), Goossens, G.H. (author), van Mil, E.G.A.H. (author), van Spanje, M.C. (author), Mariman, E.C.M. (author) article 2012
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Vos, P.A.J.M. (author), Mastbergen, S.C. (author), Huisman, A.M. (author), de Boer, T.N. (author), de Groot, J. (author), Polak, A.A. (author), Lafeber, F.P.J.G. (author)Objectives: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence...article 2012
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Hogenkamp, P.S. (author), Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author)Food intake and a food’s expected satiating effect initially rely on sensory attributes. People will learn about the food’s satiating capacity by exposure. We investigated whether repeated consumption changed the expected satiety effects and intake of iso-energetic liquid and semi-solid foods. In a randomised cross-over study, participants (n =...article 2012
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Venema, K. (author)This review describes the recent advances in technology to study fermentation of lactose and its prebiotic derivatives, including human milk oligosaccharides. Novel molecular tools to identify members of the microbiota that ferment these substrates are highlighted, as well as the use of stable isotope-labelled substrates to be able to trace...article 2012
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Vos, P.A.J.M. (author), Degroot, J. (author), Barten-Van Rijbroek, A.D. (author), Zuurmond, A.-M. (author), Bijlsma, J.W.J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)Osteoarthritis is a highly prevalent disease, age being the main risk factor. The age-related accumulation of advanced-glycation-endproducts (AGEs) adversely affects the mechanical and biochemical properties of cartilage. The hypothesis that accumulation of cartilage AGEs in combination with surgically induced damage predisposes to the...article 2012
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- Venema, K. (author) article 2012
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van Spil, W.E. (author), Jansen, N.W.D. (author), Bijlsma, J.W.J. (author), Reijman, M. (author), de Groot, J. (author), Welsing, P.M.J. (author), Lafeber, F.P.J.G. (author)Objective: To assess a wide spectrum of biochemical markers (biomarkers) in a large cohort of individuals with (very) early symptomatic knee and/or hip osteoarthritis (OA). Secondly, to investigate associations between biomarkers and between biomarkers and demographics to demonstrate validity of the obtained dataset and further investigate the...article 2012
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Gubbels, J.S. (author), Kremers, S.P.J. (author), Goldbohm, R.A. (author), Stafleu, A. (author), Thijs, C. (author)Objective The current study examined clustering of dietary intake and activity behaviours (i.e. physical activity (PA) and sedentary behaviour) in 5-year-old children, as well as the longitudinal association with BMI and overweight development. Design Principal component analysis (PCA) was used to identify behavioural patterns. Backward...article 2012
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Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author)Foods differ in their satiating capacity. Satiety peptides may help to provide evidence for biological mechanisms behind these differences. The aim of this paper was to discuss the physiological relevance of three individual appetite peptides, i.e. CCK, GLP-1 and PYY, in assessing the satiating capacity of foods. A literature research was...article 2012
Searched for: subject%3A%22PHS%255C%2B%255C-%255C%2BPharmacokinetics%255C%2B%2526%255C%2BHuman%255C%2BStudies%22
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