Searched for: subject%3A%22PHS%255C%2B%255C-%255C%2BPharmacokinetics%255C%2B%2526%255C%2BHuman%255C%2BStudies%22
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Al-Moniee, M.A. (author), Al-Abeedi, F.N. (author), Koopal, C.G.J. (author), Akmal, N. (author), Sanders, P.F. (author), van Veen, S. (author)Anaerobic microorganisms which are frequently associated with corrosion fail Control of bacterial activity are posing major challenge in Saudi Arabia's massive seawater flooding systems. Biocides are used to control bacteria throughout the oil industry. A study to explore the feasibility to develop a detection technique for biocide batch...conference paper 2013
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Vos, P.A.J.M. (author), Welsing, P.M.J. (author), de Groot, J. (author), Huisman, A.M. (author), Oostveen, J.C.M. (author), Reijman, M. (author), Damen, J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)Age-related changes in articular cartilage are likely to play a role in the etiology of osteoarthritis (OA). One of the major age-related changes in cartilage is the accumulation of advanced glycation end products (AGEs). The present study evaluates whether pentosidine can predict radiographic progression and/or burden over 5 years follow-up in...article 2013
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Venema, K. (author), van den Abbeele, P. (author)The human gut contains a diverse microbiota with large potential to influence health. Given the difficulty to access the main sites of the gut, in vitro models have been developed to dynamically monitor microbial processes at the site of metabolic activity. These models range from simple batch fermentations to complex multi-compartmental...article 2013
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Balvers, M.G.J. (author), Verhoeckx, K.C.M. (author), Meijerink, J. (author), Wortelboer, H.M. (author), Witkamp, R.F. (author)Palmitoylethanolamide (PEA) belongs to the N-acyl ethanolamines (NAEs), a group of endogenous compounds involved in a variety of physiological processes, including energy homeostasis and inflammation. This review focuses on the analysis of PEA in plasma and tissues and discusses effects of diet and some pathological processes on PEA levels....article 2013
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Havenaar, R. (author), Anneveld, B. (author), Hanff, L.M. (author), de Wildt, S.N. (author), de Koning, B.A.E. (author), Mooij, M.G. (author), Lelieveld, J.P.A. (author), Minekus, M. (author)There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic, computer-controlled in vitro system mimicking the...article 2013
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Ellens, H. (author), Deng, S. (author), Coleman, J. (author), Bentz, J. (author), Taub, M.E. (author), Ragueneau-Majlessi, I. (author), Chung, S.P. (author), Herédi-Szabó, K. (author), Neuhoff, S. (author), Palm, J. (author), Balimane, P. (author), Zhang, L. (author), Jamei, M. (author), Hanna, I. (author), O'connor, M. (author), Bednarczyk, D. (author), Forsgard, M. (author), Chu, X. (author), Funk, C. (author), Guo, A. (author), Hillgren, K.M. (author), Li, L. (author), Pak, A.Y. (author), Perloff, E.S. (author), Rajaraman, G. (author), Salphati, L. (author), Taur, J.-S. (author), Weitz, D. (author), Wortelboer, H.M. (author), Xia, C.Q. (author), Xiao, G. (author), Yamagata, T. (author), Lee, C.A. (author)In the 2012 Food and Drug Administration (FDA) draft guidance on drug-drug interactions (DDIs), a new molecular entity that inhibits Pglycoprotein (P-gp) may need a clinical DDI study with a P-gp substrate such as digoxin when themaximumconcentration of inhibitor at steady state divided by IC50 ([I1]/IC50) is0.1 or concentration of inhibitor...article 2013
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Sybesma, W. (author), Molenaar, D. (author), van IJcken, W. (author), Venema, K. (author), Korta, R. (author)We describe here a comparative genome analysis of three dairy product isolates of Lactobacillus rhamnosus GG (LGG) and the ATCC 53103 reference strain to the published genome sequence of L. rhamnosus GG. The analysis showed that in two of three isolates, major DNA segments were missing from the genomic islands LGGISL1,2. The deleted DNA segments...article 2013
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de Jong, L. (author)The role of our intestinal microbiota reaches far beyond fermentation of indigestible food components. Apart from immunological functions, they have a major impact on our metabolic and perhaps even mental health. Dutch research organization TNO is exploring this exciting field, known as host-microbiota interactions, and is developing and...article 2013
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Tchebotareva, A. (author), Schols, R.M. (author), Wieringa, F.P. (author), Alić, L. (author), Bouvy, N. (author), Stassen, L.P.S. (author), van de Steeg, E. (author), Klomp, D. (author), Baumer, S. (author), Statham, A. (author), Dunias, P. (author)One of the challenges during surgery is to make a proper distinction between vital tissues, structures and organs, both at the surface of the exposed area and beneath it. Currently, identification of different tissue types relies either on the skills and anatomical knowledge of the surgeon (e.g., nerves, blood vessels, different tissue types),...conference paper 2013
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Pasman, W.J. (author), van Erk, M.J. (author), Klöpping, W.A.A. (author), Pellis, L. (author), Wopereis, S. (author), Bijlsma, S. (author), Hendriks, H.F.J. (author), Kardinaal, A.F.M. (author)We aimed to explore whether vegetable consumption according to guidelines has beneficial health effects determined with classical biomarkers and nutrigenomics technologies. Fifteen lean (age 36 ± 7 years; BMI 23.4 ± 1.7 kg m-2) and 17 obese (age 40 ± 6 years; BMI 30.3 ± 2.4 kg m-2) men consumed 50- or 200-g vegetables for 4 weeks in a randomized...article 2013
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- Clabbers, N. (author), van Dijken, P. (author), van Gool, A. (author), van der Greef, J. (author), de Groot, J. (author), Hendriks, H. (author), van Meeteren, N. (author), Mooij, R. (author), van Ommen, B. (author), Rietkerk, O. (author), Snoeij, N. (author), van Staalduinen, W. (author), Stadlander, M. (author), Wevers, C. (author), Wieringa, F. (author) report 2013
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Vogt, L. (author), Ramasamy, U. (author), Meyer, D. (author), Pullens, G. (author), Venema, K. (author), Faas, M.M. (author), Schols, H.A. (author), de Vos, P. (author)Introduction:beta2→1-fructans are dietary fibers. Main objectives of this study were 1) to demonstrate direct signalling of beta2→1-fructans on immune cells, 2) to study whether this is mediated by the pattern recognition receptors Toll-like receptors (TLRs) and nucleotide-binding oligomerisation domain-containing proteins (NODs), and 3) to...article 2013
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Altorf-van der Kuil, W. (author), Brink, E.J. (author), Boetje, M. (author), Siebelink, E. (author), Bijlsma, S. (author), Engberink, M.F. (author), Veer, P.V.'. (author), Tomé, D. (author), Bakker, S.J.L. (author), van Baak, M.A. (author), Geleijnse, J.M. (author)In the present controlled, randomised, multiple cross-over dietary intervention study, we aimed to identify potential biomarkers for dietary protein from dairy products, meat and grain, which could be useful to estimate intake of these protein types in epidemiological studies. After 9 d run-in, thirty men and seventeen women (22 (sd 4) years)...article 2013
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van den Berg, E. (author), Engberink, M.F. (author), Brink, E.J. (author), van Baak, M.A. (author), Gans, R.O.B. (author), Navis, G. (author), Bakker, S.J.L. (author)Hypertension is highly prevalent among renal transplant recipients (RTR) and a risk factor for graft failure and cardiovascular events. Protein intake has been claimed to affect blood pressure (BP) in the general population and may affect renal function. We examined the association of dietary protein with BP and renal function in RTR. We...article 2013
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Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challengesWopereis, S. (author), Wolvers, D. (author), van Erk, M.J. (author), Gribnau, M. (author), Kremer, S.H.A. (author), van Dorsten, F.A. (author), Boelsma, E. (author), Garczarek, U. (author), Cnubben, N. (author), Frenken, L. (author), der Logt P, van (author), Hendriks, H.F. (author), Albers, R. (author), van Duynhoven, J. (author), van Ommen, B. (author), Jacobs, D.M. (author)Background: Resilience or the ability of our body to cope with daily-life challenges has been proposed as a new definition of health, with restoration of homeostasis as target resultant of various physiological stress responses. Challenge models may thus be a sensitive measure to study the body’s health. The objective of this study was to select...article 2013
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Rehman, A. (author), Heinsen, F.A. (author), Koenen, M.E. (author), Venema, K. (author), Knecht, H. (author), Hellmig, S. (author), Schreiber, S. (author), de Ott, S.J. (author)Background: Antibiotic associated diarrhea and Clostridium difficile infection are frequent complications of broad spectrum antibiotic therapy. Probiotic bacteria are used as therapeutic and preventive agents in these disorders, but the exact functional mechanisms and the mode of action are poorly understood. The effects of clindamycin and the...article 2012
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- Dutman, E. (author), Pasman, W. (author), Stafleu, A. (author) article 2012
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Roeselers, G. (author), Bouwman, J. (author), Venema, K. (author), Montijn, R. (author)The mammalian gastrointestinal tract (GIT) harbors microorganisms (the microbiota) of vast phylogentic, genomic, and metabolic diversity, and recent years have seen a rapid development in the techniques for studying these complex microbial ecosystems. It is increasingly apparent that the GIT microbiota plays an intricate role in host health and...article 2012
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van den Berg, E. (author), Geleijnse, J.M. (author), Brink, E.J. (author), van Baak, M.A. (author), Homan van der Heide, J.J. (author), Gans, R.O.B. (author), Navis, G. (author), Bakker, S.J.L. (author)Background. Hypertension is common among renal transplant recipients (RTR) and a risk factor for graft failure and mortality. Sodium intake is a well-established determinant of blood pressure (BP) in the general population. However, data in RTR are limited. International guidelines recommend a maximum daily sodium intake of 70 mmol. We...article 2012
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Björck, I. (author), Östman, E. (author), Kristensen, M. (author), Mateo Anson, N. (author), Price, R.K. (author), Haenen, G.R.M.M. (author), Havenaar, R. (author), Bach Knudsen, K.E. (author), Frid, A. (author), Mykkänen, H. (author), Welch, R.W. (author), Riccardi, G. (author)Epidemiological studies have linked whole grain intake to the prevention of the metabolic syndrome, obesity and associated chronic diseases such as CVD and T2D. The Nutrition module within the HEALTHGRAIN project, included 10 partners and undertook in vitro, animal and human in vivo studies with the overall aims of elucidating the components and...article 2012
Searched for: subject%3A%22PHS%255C%2B%255C-%255C%2BPharmacokinetics%255C%2B%2526%255C%2BHuman%255C%2BStudies%22
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