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van Raaij, J.A.G.M. (author), Frijters, C.M.G. (author), Wong Yen Kong, L. (author), van den Berg, K.J. (author), Notten, W.R.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In the present study the effects of hexachlorobenzene (HCB) and the metabolite pentachlorophenol (PCP) were investigated with respect to uptake of thyroxine (T4) into cerebrospinal fluid (CSF) and brain structures of rats. [125I]T4 was taken up into CSF of control rats by a relatively slow process, reaching a steady state after about 3 h. Both...article 1994
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van den Berg, K.J. (author), van Raaij, J.A.G.M. (author), Bragt, P.C. (author), Notten, W.R.F. (author), Medisch Biologisch Laboratorium TNO (author)Previous results in experimental systems have suggested that hydroxylated PCBs may decrease thyroid hormone levels through associative interaction with transthyretin. In the present paper it was investigated whether this property was also shared by various industrial chemicals, mainly pesticides. In total, 65 compounds from 12 chemical groups...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Koëter, H.B.W.M. (author), Blijleven, W.G.H. (author), Dreef-van der Meulen, H.C. (author), Stijkel, A. (author), Zielhuis, R.L. (author)According to a study in animals described by Schwetz et al. (1974), pentachlorophenol induces embryotoxic and teratogenic effects whereas Welsh et al. (1987) reported embryolethal effects. Further any animal and human data with respect to endocrine system, gonads and fertility are lacking. Data on offspring are inadequate for evaluation. It is...book 1989
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Centraal instituut voor voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO (author), Geuskens, R.B.M. (author), Nossent, S.M. (author), Koëter, H.B.W.M. (author), Dreef-van der Meulen, H.C. (author), Stijkel, A. (author), Zielhuis, R.l. (author)De gezondheidsrisico's i.v.m. het werken met pentachloorfenol (PCP) wordt geevalueerd. Het gebruik van PCP in Nederlandse arbeidssituaties neemt sterk af en is beperkt tot de formulering van emeltenkorrels en de, met name preventieve, houtverduurzaming. De totale risicopopulatie is niet omvangrijk en bestaat geheel uit mannen. De belangrijkste...book 1989