The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus

Background: The burden of cardiovascular disease in diabetes mellitus type 2 (DM2) patients is variable. We hypothesize that metabolic syndrome (MS) and low-grade systemic inflammation modify the extent of atherosclerosis in DM2. Methods: Vascular phenotype was determined using the following endothelium-related, hemostatic, and sonographic...

Preeclampsia and its interaction with common variants in thrombophilia genes

Recently, it has been proposed that abnormalities in coagulation and fibrinolysis contribute to the development of preeclampsia by increasing the thrombotic tendency. This hypothesis was tested in women who have had preeclampsia (cases) compared with matched controls. Polymorphisms in the thrombophilia genes {plasminogen activator inhibitor type...

Relationship between visceral fat and PAI-1 in overweight men and women before and after weight loss

This study was aimed at evaluating the relationship between visceral fat accumulation and plasma plasminogen activator inhibitor-1 (PAI-1) levels in healthy, obese men and women undergoing weight loss therapy. The subjects, 25 men and 25 premenopausal women, aged between 26 and 49 years, with an initial body mass index between 28 and 38 kg/m2,...

Grupo de trabajo de Leiden sobre fibrinolysis: procedimientos de recogida y manipulación de sangre para la evaluación del activador del plasminógeno de tipo tisular (t-PA) y del inhibidor-1 del activador del plasminógeno (PAI-1) [Leiden fibrinolysis working party : blood collection and handling procedures for assessment of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1)]

Procedures of blood collection and handling are different for the various variables in haemostasis and tend to change gradually with progress in knowledge and methods. The Working Party has gathered background information about procedures and discussed minimal requirements specifically for t-PA and PAI-1 assessment. The general procedure from...