- document
-
Zerdin, K. (author), Rooney, M.L. (author), Vermuë, J. (author), TNO Voeding (author)A storage study of orange juice packed in oxygen scavenging (OS) film and oxygen barrier film was conducted to determine the extent of ascorbic acid loss due to oxygen as a function of time and temperature. The initial concentration of ascorbic acid in the orange juice was 374 mg/l and this was found to decrease by 74 and 104 mg/l after 3 days...article 2003
- document
-
Artola-Garicano, E. (author), Hermens, J.L.M. (author), Vaes, W.H.J. (author)In the current study, predictions by Simple Treat 3.0, a fate model for organic chemicals in sewage treatment plants (STPs), are compared with actual measurements in three STPs. Two polycyclic musks, Tonalide® (AHTN) and Galaxolide® (HHCB), were used for model evaluation. Results show that Simple Treat 3.0 is able to predict the removal...article 2003
- document
-
den Hartog, E.A. (author), Heus, R. (author), TNO Technische Menskunde (author)The requirements to maintain a positive pressure with respiratory protection during heavy exercise and the effects on ventilation and feelings of discomfort were investigated. Eight male subjects participated, using the respirator system during rest and exercise at about 80% of their individual maximum power. A blower was used at maximum and...article 2003
- document
-
Gaubius Instituut TNO (author), Nguyen, M.T. (author), Beck, J. (author), Lue, H. (author), Fünfzig, H. (author), Kleemann, R. (author), Koolwijk, P. (author), Kapurniotu, A. (author), Bernhagen, J. (author)Macrophage migration inhibitory factor (MIF) is a cytokine that participates in the host inflammatory response. A Cys-Xaa-Xaa-Cys (CXXC)-based thiol-protein oxidoreductase activity of MIF is associated with certain biological functions. Peptides spanning the CXXC region of thiol-protein oxidoreductases retain some biochemical properties of the...article 2003
- document
-
Tornqvist, T.E. (author), Wallinga, J. (author), Busschers, F.S. (author)We investigated, by means of optical dating, the chronostratigraphic nature of the sequence boundary associated with the last glacial in a sandy to gravelly compound paleovalley fill, just landward of the highstand shoreline in the Rhine-Meuse Delta (Netherlands). Laterally extensive fluvial strata deposited during oxygen isotope stage 4, coeval...article 2003
- document
-
TNO Voeding (author), Malan, D.D. (author), Scheele, C.W. (author), Buyse, J. (author), Kwakernaak, C. (author), Siebrits, F.K. (author), van der Klis, J.D. (author), Decuypere, E. (author)1. Male chickens of 7 genetic lines, consisting of two pure sire and two pure dam populations, a commercial broiler cross and two slow-growing chicken lines (Label Rouge, LR and Mechelse Koekoek, MK) were reared from 1 to 37 d of age. The chickens received a two-phase dietary regime and were subjected to low ambient temperature. 2. The...article 2003
- document
-
te Biesebeke, R. (author), Ruijter, G. (author), Rahardjo, Y.S.P. (author), Hoogschagen, M.J. (author), Heerikhuisen, M. (author), Levin, A. (author), van Driel, K.G.A. (author), Schutyser, M.A.I. (author), Dijksterhuis, J. (author), Zhu, Y. (author), Weber, F.J. (author), de Vos, W.M. (author), van den Hondel, K.A.M.J.J. (author), Rinzema, A. (author), Punt, P.J. (author)We report the progress of a multi-disciplinary research project on solid-state fermentation (SSF) of the filamentous fungus Aspergillus oryzae. The molecular and physiological aspects of the fungus in submerged fermentation (SmF) and SSF are compared and we observe a number of differences correlated with the different growth conditions. First,...article 2002
- document
-
Wertheim, A.H. (author), Kemper, H.C.G. (author), Heus, R. (author)In previous studies on physical fatigue during simulated ship movements, the apparent exhaustion of subjects after experimentation suggested that the traditional index of physical workload, oxygen consumption expressed as the percentage of peak oxygen consumption (VO2-peak) measured in a separate graded exercise test (GXT), underestimates...article 2002
- document
-
Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), Oudgenoeg, G. (author), Dirksen, E. (author), Ingemann, S. (author), Hilhorst, R. (author), Gruppen, H. (author), Boeriu, C.G. (author), Piersma, S.R. (author), van Berkel, W.J.H. (author), Laane, C. (author), Voragen, A.G.J. (author)Ferulic acid (FA) is an abundantly present phenolic constituent of plant cell walls. Kinetically controlled incubation of FA and the tripeptide Gly-Tyr-Gly (GYG) with horseradish peroxidase and H2O2 yielded a range of new cross-linked products. Two predominant series of hetero-oligomers of FA linked by dehydrogenation to the peptidyl tyrosine...article 2002
- document
-
Meuleman, E.E.B. (author), Willemsen, J.H.A. (author), Mulder, M.H.V. (author), Strathmann, H. (author)Various types of ethylene-propylene-diene terpolymers (EPDM) and crosslinking procedures have been investigated with pervaporation, vapor sorption, liquid sorption and gas permeation experiments. The EPDM parameters that have been changed are ethylene content, molecular weight, choice of third monomer, type of branching and various crosslinking...article 2001
- document
-
Hoebe, K.H.N. (author), Witkamp, R.F. (author), Fink-Gremmels, J. (author), van Miert, A.S.J.P.A.M. (author), Monshouwer, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This study focuses on the importance of direct contact between Kupffer cells (KCs) and hepatocytes (HCs) during the hepatic inflammatory response using an in vitro approach. The lipopolysaccharide (LPS)-induced inflammatory response in monocultures of porcine HCs and KCs were compared with cocultures prepared either with direct contact between...article 2001
- document
-
Peschel, A. (author), Jack, R.W. (author), Otto, M. (author), Collins, L.V. (author), Staubitz, P. (author), Nicholson, G. (author), Kalbacher, H. (author), Nieuwenhuizen, W.F. (author), Jung, G. (author), Tarkowski, A. (author), van Kessel, K.P.M. (author), van Strijp, J.A.G. (author)Defensins, antimicrobial peptides of the innate immune system, protect human mucosal epithelia and skin against microbial infections and are produced in large amounts by neutrophils. The bacterial pathogen Staphylococcus aureus is insensitive to defensins by virtue of an unknown resistance mechanism. We describe a novel staphylococcal gene, mprF...article 2001
- document
-
Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van den Berg, R. (author), Haenen, G.R.M.M. (author), van den Berg, H. (author), Bast, A. (author)There is increasing interest in the involvement of transcription factors, such as of the transcription factor NF-κB (nuclear factor-κB), in the pathogenesis of various diseases. NF-κB is involved in the control of the transcription of a variety of cellular genes that regulate the inflammatory response by the production of cytokines, chemokines,...article 2001
- document
-
Anderson, D. (author), Yardley-Jones, A. (author), Hambly, R.J. (author), Vives-Bauza, C. (author), Smykatz-Kloss, V. (author), Chua-anusorn, W. (author), Webb, J. (author), TNO BIBRA International (author)Thalassaemia is a group of genetic diseases where haemoglobin synthesis is impaired. This chronic anaemia leads to increased dietary iron absorption, which develops into iron overload pathology. Treatment through regular transfusions increases oxygen capacity but also provides iron through the red cells' haemoglobin. An essential treatment, in...article 2000
- document
-
Izeboud, C.A. (author), Monshouwer, M. (author), Witkamp, R.F. (author), van Miert, A.S.J. (author), TNO Voeding (author)During infection and inflammation drug disposition and hepatic metabolism are markedly affected in mammals. Pro-inflammatory mediators play an important role in the suppression of (cytochrome-P450-mediated) drug metabolism. Inflammatory mediators like cytokines, nitric oxide (NO), reactive oxygen species (ROS) and eicosanoids are released by...article 2000
- document
-
Dorrepaal, C.A. (author), van Bel, F. (author), Steendijk, P. (author), Shadid, M. (author), van de Velde, E.T. (author), Baan, J. (author), TNO Preventie en Gezondheid (author)The aim of the present study was to investigate the effect of immediate post-hypoxic-ischemic (HI) inhibition of nitric oxide synthesis by N(ω)- nitro-L-arginine (NLA) on cardiac function and reactive oxygen species production. Fifteen newborn lambs were subjected to severe HI. Upon resuscitation 5 received 10 mg NLA/kg, 4 40 mg NLA/kg and 6 a...article 2000
- document
-
Kroon, M.E. (author), Koolwijk, P. (author), van der Vecht, B. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)Hypoxia stimulates angiogenesis, the formation of new blood vessels. This study evaluates the direct effect of hypoxia (1% oxygen) on the angiogenic response of human microvascular endothelial cells (hMVECs) seeded on top of a 3-dimensional fibrin matrix, hMVECs stimulated with fibroblast growth factor-2 (FGF-2) or vascular endothelial growth...article 2000
- document
-
de Bie, T. (author), Ericsson, M. (author), Rask, P. (author), TNO Wegtransportmiddelen Society of Automotive Engineers (author)This paper presents a start algorithm that is able to control the air/fuel ratio (AFR) during the cranking phase and immediately hereafter, where the ordinary ?-control is not yet enabled. The control is based on the ion sense principle, which means that a current through the spark plug is measured directly after the spark has disappeared. This...conference paper 2000
- document
-
Anderson, D. (author), Phillips, B.J. (author), Yu, T-W. (author), Edwards, A.J. (author), Ayesh, R. (author), Butterworth, K.R. (author)Twenty-four men and 24 women, all nonsmoking, and maintaining normal dietary habits were assigned to 3 groups of 16. Each group comprising 4 males with "low" cholesterol levels (<6 mmol/L) matched for age and build with 4 males with "high" cholesterol levels (>6 mmol/L) and 8 similarly matched females. A three-treatment, three-treatment period,...article 2000
- document
-
Smits, J.P. (author), van Sonsbeek, H.M. (author), Knol, W. (author), Tramper, J. (author), Geelhoed, W. (author), Peeters, M. (author), Rinzema, A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)The theoretical mathematical models described in this paper are used to evaluate the effects of fungal biomass inactivation kinetics on a non- isothermal tray solid-state fermentation (SSF). The inactivation kinetics, derived from previously reported experiments done under isothermal conditions and using glucosamine content to represent the...article 1999