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van Helvoort, P.J. (author), Griffioen, J. (author), Hartog, N. (author), TNO Bouw en Ondergrond (author)Large groundwater resources are found in densely populated lowland areas, which consist often of young unconsolidated and reduced sediments. When anthropogenic activities lead to oxygenation of the aquifer, breakdown of the main reduced fractions, i.e. sedimentary organic matter (SOM) and pyrite, could lead to severe groundwater deterioration...article 2007
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Wieringa, F.P. (author), Mastik, F. (author), Boks, R.H. (author), Visscher, A. (author), Bogers, A. (author), van der Steen, A.F.W. (author), TNO Industrie en Techniek (author)Feasibility of pulse oxigraphy is examined using an in- vitro phantom, perfused with human blood by a heart- lung machine. 29 different oxygen saturation levels, measured with our experimental camera and a clinical pulse oximeter, were matched against laboratory blood gas analysis. Discrete transfer functions between measurements & laboratory...conference paper 2007
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TNO Kwaliteit van Leven (author), Beulens, J.W.J. (author), van Loon, L.J.C. (author), Kok, F.J. (author), Pelsers, M. (author), Bobbert, T. (author), Spranger, J. (author), Helander, A. (author), Hendriks, H.F.J. (author)Aims/hypothesis: The aim of this study was to investigate whether moderate alcohol consumption increases plasma high molecular weight (HMW) adiponectin and/or muscle oxidative capacity. Materials and methods: Eleven lean (BMI 18-25 kg/m2) and eight overweight (BMI ≥27 kg/m2) men consumed 100 ml whisky (∼32 g alcohol) or water daily for 4 weeks...article 2007
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Gaubius Instituut TNO (author), van den Hoek, A.M. (author), Heijboer, A.C. (author), Voshol, P.J. (author), Havekes, L.M. (author), Romijn, J.A. (author), Corssmit, E.P.M. (author), Pijl, H. (author)PYY3-36 is a gut-derived hormone acting on hypothalamic nuclei to inhibit food intake. We recently showed that PYY3-36 acutely reinforces insulin action on glucose disposal in mice. We aimed to evaluate effects of PYY3-36 on energy metabolism and the impact of chronic PYY3-36 treatment on insulin sensitivity. Mice received a single injection of...article 2007
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Vuyk, J. (author), van den Bos, J. (author), Terhell, K. (author), de Bos, R. (author), Vletter, A. (author), Valk, P. (author), van Beuzekom, M. (author), van Kleef, J. (author), Dahan, A. (author), TNO Technische Menskunde (author)Acute mountain sickness is thought to be triggered by cerebral hypoxemia and be prevented by acetazolamide (Actz). The effect of Actz on cerebral oxygenation at altitude remains unknown. In 16 members of the 2005 Dutch Cho Oyu (8201 m, Tibet) expedition, the influence of Actz and exercise (750 mg PO daily) on heart rate, peripheral and regional...article 2006
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Jellema, W.T. (author), Groeneveld, A.B.J. (author), Wesseling, K.H. (author), Thijs, L.G. (author), Westerhof, N. (author), van Lieshout, J.J. (author)OBJECTIVE: To establish the heterogeneity of hemodynamic responses to dobutamine in patients with septic shock and to identify the predictive factors of these hemodynamic responses. DESIGN: Prospective study. SETTING AND PATIENTS: A total of 12 patients with septic shock in a tertiary medical intensive care unit. INTERVENTIONS: A 20-min...article 2006
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Daanen, H.A.M. (author), van Es, E.M. (author), de Graaf, J.L. (author), TNO Defensie en Veiligheid (author)The maximal power that muscles can generate is reduced at low muscle temperatures. However, in prolonged heavy exercise in the heat, a high core temperature may be the factor limiting performance. Precooling has been shown to delay the attainment of hyperthermia. It is still unclear if the whole body should be cooled or if the active muscles...article 2006
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van der Vaart, R. (author), Petrova, I. (author), Lebedeva, V. (author), Volkov, V. (author), Kochubey, D. (author), Tereshchenko, G. (author), TNO Industrie en Techniek (author)Dissolved oxygen is one of the major contaminants to be removed for the production of ultrapure water, e.g., for the semiconductor industry or for boiler feed water preparation in electricity production. Also, in the brewing of beer (heavy brewing) and in the oil and gas industry (injection water) oxygen removal is important. For the removal of...article 2006
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TNO Defensie en Veiligheid (author), Kieboom, J. (author), Abee, T. (author)Salmonella enterica serovar Typhimurium does not survive a pH 2.5 acid challenge under conditions similar to those used for Escherichia coli (J. W. Foster, Nat. Rev. Microbiol. 2:898-907, 2004). Here, we provide evidence that S. enterica serovar Typhimurium can display arginine-dependent acid resistance (AM) provided the cells are grown under...article 2006
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TNO Industrie en Techniek (author), Laimböck, P.R. (author), Beerkens, R.G.C. (author)The development of a special oxygen sensor for the continuous measurement of equilibrium oxygen pressure and oxygen content in the float bath of a float-glass production line was discussed. The measuring principle is based on an electrochemical cell where the core of the sensor consist of a metal-metal oxide mix in a fully-yttria-stabilized...article 2006
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Nederlands Instituut voor Toegepaste Geowetenschappen TNO (author), van der Weijden, C.H. (author), Reichart, G.J. (author), van Os, B.J.H. (author)Two piston cores (PCs), containing two full glacial cycles, were retrieved at Murray Ridge. One core (PC463) contains sediment deposited at 920 mbsl within, the other (PC464) has sediment deposited at 1470 mbsl below the current oxygen minimum zone, OMZ (O2: ≤ 2 μM). Variations in the organic carbon (OC) content correlate well between the two...article 2006
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Brinckmann, J. (author), Kim, S. (author), Wu, J. (author), Reinhardt, D.P. (author), Batmunkh, C. (author), Metzen, E. (author), Notbohm, H. (author), Bank, R.A. (author), Krieg, T. (author), Hunzelmann, N. (author), TNO Kwaliteit van Leven (author)The major pathological processes of systemic scleroderma (SSc) comprise inflammation and microvascular damage in the early or acute progressive stage as well as tissue fibrosis and hypoxia in the chronic end stage. Fibrosis seems to be a general phenomenon characterized by an increase of hydroxylysine aldehyde derived collagen cross-links which...article 2005
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Wieringa, F.P. (author), Mastik, F. (author), van der Steen, A.F.W. (author), TNO Kwaliteit van Leven (author)We describe a route toward contactless imaging of arterial oxygen saturation (SpO2) distribution within tissue, based upon detection of a two-dimensional matrix of spatially resolved optical plethysmographic signals at different wavelengths. As a first step toward SpO 2-imaging we built a monochrome CMOS-camera with apochromatic lens and 3λ-LED...article 2005
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Hage, J.C. (author), van Houten, R.T. (author), Tramper, J. (author), Hartmans, S. (author)A membrane-aerated biofilm reactor (MBR) with a biofilm of Pseudomonas sp. strain DCA1 was studied for the removal of 1,2-dichloroethane (DCA) from water. A hydrophobic membrane was used to create a barrier between the liquid and the gas phase. Inoculation of the MBR with cells of strain DCA1 grown in a continuous culture resulted in the...article 2004
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Bakker, D.P. (author), Busscher, H.J. (author), van Zanten, J. (author), de Vries, J. (author), Klijnstra, J.W. (author), van der Mei, H.C. (author), TNO Industrie (author)Many studies have shown relationships of substratum hydrophobicity, charge or roughness with bacterial adhesion, although bacterial adhesion is governed by interplay of different physico-chemical properties and multiple regression analysis would be more suitable to reveal mechanisms of bacterial adhesion. The formation of a conditioning film of...bookPart 2004
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Raming, T.P. (author), van Zyl, W.E. (author), Carton, E.P. (author), Verweij, H. (author)Yttria-doped zirconia/ruthenia powders were made by co-precipitation. The calcined powders were compacted into green compacts using standard pressing techniques such as isostatical compaction compared to explosive compaction. Explosive compaction (EC) led to the highest density, but also to cracking of the compacts. The zirconia/ruthenia powders...article 2004
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Influence of inspiratory resistance on performance during graded exercise tests on a cycle ergometerHeus, R. (author), den Hartog, E.A. (author), Kistemaker, L.J.A. (author), van Dijk, W.J. (author), Swenker, G. (author), TNO Technische Menskunde (author)Due to more stringent requirements to protect personnel against hazardous gasses, the inspiratory resistance of the present generation of respiratory protective devices tends to increase. Therefore an important question is to what extent inspiratory resistance may increase without giving problems during physical work. In this study the effects...article 2004
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TNO Preventie en Gezondheid (author), Jukema, J.W. (author), van der Hoorn, J.W.A. (author)Hypertension and hyperlipidaemia are major risk factors for the development of atherosclerosis. Calcium channel blockers (CCBs) have been used for decades and have established antihypertensive effects. Statins have been extensively used because of their potent lipid lowering properties. Amongst other factors, inflammation and oxidation are...article 2004
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López-Cervantes, L. (author), Sánchez-Machado, D.I. (author), Pastorelli, S. (author), Rijk, R. (author), Paseiro-Losada, P. (author), TNO Voeding (author)The behaviour of two commercial oxygen-scavenging products with respect to migration of active ingredients into foodstuffs was investigated. Migrants were identified, and by using appropriate analytical methods, migration was determined in a variety of liquid, solid or gelled food simulants and foods. Simulants were chosen to cover a range of...article 2003
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de Klerk, W.P.C. (author), Boers, M.N. (author), Prins Maurits Laboratorium TNO (author)Stability research on gun propellants has been widely performed by microcalorimetry since the 1980s. TNO Prins Maurits Laboratory has already a broad experience since the early 1970s. In the past many studies were performed, to investigate the influence of oxygen, humidity etc. Less attention was paid to two other important aspects, namely the...article 2003