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Bourgonje, A.R. (author), Offringa, A.K. (author), van Eijk, L.E. (author), Abdulle, A.E. (author), Hillebrands, J.L. (author), van der Voort, P.H.J. (author), van Goor, H. (author), van Hezik, E.J. (author)Significance: Hydrogen sulfide (H2S) is one of the three main gasotransmitters that are endogenously produced in humans and are protective against oxidative stress. Recent findings from studies focusing on coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shifted our attention to a...article 2021
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- Burello, E. (author), Worth, A.P. (author) article 2015
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Poot, A. (author), Quik, J.T.K. (author), Veld, H. (author), Koelmans, A.A. (author), TNO Bouw en Ondergrond (author)Black Carbon (BC) quantification methods are reviewed, including new Rock-Eval 6 data on BC reference materials. BC has been reported to have major impacts on climate, human health and environmental quality. Especially for risk assessment of persistent organic pollutants (POPs) it is important to account for risk reduction caused by BC, as...article 2009
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Griffioen, J. (author), Passier, H.F. (author), Klein, J. (author), TNO Bouw en Ondergrond (author)Establishment of natural background levels (NBL) for groundwater is commonly performed to serve as reference when assessing the contamination status of groundwater units. We compare various selection methods to establish NBLs using groundwater quality data forfour hydrogeologically different areas in the highly populated and developed...article 2008
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Stierum, R. (author), Conesa, A. (author), Heijne, W. (author), Ommen, B.v. (author), Junker, K. (author), Scott, M.P. (author), Price, R.J. (author), Meredith, C. (author), Lake, B.G. (author), Groten, J. (author), TNO Kwaliteit van Leven (author), KvL (author)Transcriptomics was performed to gain insight into mechanisms of food additives butylated hydroxytoluene (BHT), curcumin (CC), propyl gallate (PG), and thiabendazole (TB), additives for which interactions in the liver can not be excluded. Additives were administered in diets for 28 days to Sprague-Dawley rats and cDNA microarray experiments were...article 2008
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Vermeulen, J. (author), van Gool, M.P.M. (author), Dorleijn, A.S. (author), Joziasse, J. (author), Bruning, H. (author), Rulkens, W.H. (author), Grotenhuis, J.T.C. (author), TNO Bouw en Ondergrond (author)After dredged sediments have settled in a temporary upland disposal site, ripening starts, which turns waterlogged sediment into aerated soil. Aerobic biological mineralization of organic matter (OM) and chemical oxidation of reduced sulfur compounds are the major biochemical ripening processes. Quantitative data describing these processes are...article 2007
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Weelink, S.A.B. (author), Tan, N.C.G. (author), ten Broeke, H. (author), van Doesburg, W. (author), Langenhoff, A.A.M. (author), Gerritse, J. (author), Stams, A.J.M. (author), TNO Bouw en Ondergrond (author)A stable anoxic enrichment culture was obtained that degraded benzene with chlorate as an electron acceptor. The benzene degradation rate was 1.65 mM benzene per day, which is similar to reported aerobic benzene degradation rates but 20-1650 times higher than reported for anaerobic benzene degradation. Denaturing gradient gel electrophoresis of...article 2007
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Ganzevles, R.A. (author), Kosters, H. (author), van Vliet, T. (author), Stuart, M.A.C. (author), de Jongh, H.H.J. (author), TNO Kwaliteit van Leven (author)Because the formation of protein/polysaccharide complexes is dominated by electrostatic interaction, polysaccharide charge density is expected to play a major role in the adsorption behavior of the complexes. In this study, pullulan (a non-charged polysaccharide) carboxylated to four different charge densities (fraction of carboxylated subunits:...article 2007
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Oudshoorn, J.H. (author), Lecluse, A.L.Y. (author), van den Berg, R. (author), Vaes, W.H.J. (author), van der Laag, J. (author), Houwen, R.H.J. (author), TNO Kwaliteit van Leven (author)OBJECTIVES: Coenzyme Q10 (CoQ10) is an effective lipophilic antioxidant and protects against lipid peroxidation by scavenging radicals. Patients with cystic fibrosis generally have fat malabsorption; thus, we hypothesized that overall plasma CoQ10 concentration in pediatric patients with cystic fibrosis might be diminished. Because these...article 2006
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Caspary, F. (author), Elliott, G. (author), Navé, B.T. (author), Verzaal, P. (author), Rohrbach, M. (author), Das, P.K. (author), Nagelkerken, L. (author), Nieland, J.D. (author), Gaubius Instituut TNO (author)Background: The dogma in psoriasis is that due to pathogen-induced inflammatory responses, an autoreactive immune response is induced that leads to tissue destruction. However, this model might be too simplistic. Literature data suggest that the expression of enzymes crucial for fatty acid oxidation is upregulated in the skin of patients with...article 2005
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TNO Kwaliteit van Leven (author), Grefhorst, A. (author), Hoekstra, J. (author), Derks, T.G.J. (author), Ouwens, D.M. (author), Baller, J.F.W. (author), Havinga, R. (author), Havekes, L.M. (author), Romijn, J.A. (author), Kuipers, F. (author)Accumulation of triglycerides (TG) in the liver is generally associated with hepatic insulin resistance. We questioned whether acute hepatic steatosis induced by pharmacological blockade of β-oxidation affects hepatic insulin sensitivity, i.e., insulin-mediated suppression of VLDL production and insulin-induced activation of phosphatidylinositol...article 2005
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TNO Kwaliteit van Leven (author), Duivenvoorden, I. (author), Teusink, B. (author), Rensen, P.C.N. (author), Kuipers, F. (author), Romijn, J.A. (author), Havekes, L.M. (author), Voshol, P.J. (author)Hepatic VLDL and glucose production is enhanced in type 2 diabetes and associated with hepatic steatosis. Whether the derangements in hepatic metabolism are attributable to steatosis or to the increased availability of FA metabolites is not known. We used methyl palmoxirate (MP), an inhibitor of carnitine palmitoyl transferase I, to acutely...article 2005
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TNO Voeding (author), van der Woude, H. (author), Alink, G.M. (author), van Rossum, B.E.J. (author), Walle, K. (author), van Steeg, H. (author), Walle, T. (author), Rietjens, I.M.C.M. (author)This study investigates the role of cellular tyrosinase and/or peroxidase-like oxidative enzyme activity in the covalent binding of quercetin to glutathione, protein, and DNA, as well as the stability of quercetin DNA adducts in time. This was done by studying the formation of glutathionyl quercetin adducts in various in vitro models, and the...article 2005
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Hueber-Becker, F. (author), Nohynek, G.J. (author), Meuling, W.J.A. (author), Benech-Kieffer, F. (author), Toutain, H. (author), TNO Voeding (author)We investigated the absorption of a commercial [14C]-PPD- containing oxidative dark-shade hair dye in human volunteers as well as in vitro using human or pig ear skin. The hair of eight male volunteers was cut to a standard length, dyed, washed, dried, clipped and collected. Hair, washing water, materials used in the study and a 24-h scalp wash...article 2004
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Sigoillot, C. (author), Record, E. (author), Belle, V. (author), Robert, J.L. (author), Levasseur, A. (author), Punt, P.J. (author), van den Hondel, C.A.M.J.J. (author), Fournel, A. (author), Sigoillot, J.C. (author), Asther, M. (author), TNO Voeding (author)Three laccases, a natural form and two recombinant forms obtained from two different expression hosts, were characterized and compared for paper pulp bleaching. Laccase from Pycnoporus cinnabarinus, a well known lignolytic fungus, was selected as a reference for this study. The corresponding recombinant laccases were produced in Aspergillus...article 2004
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Gaubius Instituut TNO (author), Nguyen, M.T. (author), Beck, J. (author), Lue, H. (author), Fünfzig, H. (author), Kleemann, R. (author), Koolwijk, P. (author), Kapurniotu, A. (author), Bernhagen, J. (author)Macrophage migration inhibitory factor (MIF) is a cytokine that participates in the host inflammatory response. A Cys-Xaa-Xaa-Cys (CXXC)-based thiol-protein oxidoreductase activity of MIF is associated with certain biological functions. Peptides spanning the CXXC region of thiol-protein oxidoreductases retain some biochemical properties of the...article 2003
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TNO Voeding (author), Awad, H.M. (author), Boersma, M.G. (author), Boeren, S. (author), van Bladeren, P.J. (author), Vervoort, J. (author), Rietjens, I.M.C.M. (author)Oxidation of flavonoids with a catechol structural motif in their B ring leads to formation of flavonoid quinone/quinone methides, which rapidly react with GSH to give reversible glutathionyl flavonoid adducts. Results of the present study demonstrate that as a thiol-scavenging agent for this reaction Cys is preferred over GSH and N...article 2003
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Faber, A.J. (author)Advanced experimental techniques to measure the spectral absorption and oxidation state of silicate glass melts are described. Exemplary results of the characterisation of industrial glass melts by these two methods are presented. The technological impact of the high-temperature optical properties and oxidation state of glass melts on radiative...article 2002
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Heeres, A. (author), van Doren, H.A. (author), Gotlieb, K.F. (author), Bleeker, I.P. (author), Bergsma, J. (author), Kellogg, R.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Granular 2-nitropropyl potato starch was synthesized by reaction with 2-nitropropyl acetate in an aqueous suspension. Nitroalkylation occurs preferentially with the amylose fraction of potato starch, as was confirmed by leaching experiments and digestion of the modified starch with α-amylase. The 2-nitropropyl substituent is a mixture of the...article 2001
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Oudgenoeg, G. (author), Hilhorst, R. (author), Piersma, S.R. (author), Boeriu, C.G. (author), Gruppen, H. (author), Hessing, M. (author), Voragen, A.G.J. (author), Laane, C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The tyrosine-containing peptide Gly-Tyr-Gly (GYG) was oxidatively cross-linked by horseradish peroxidase in the presence of hydrogen peroxide. As products, covalently coupled di- to pentamers of the peptide were identified by LC-MS. Oxidative cross-linking of ferulic acid with horseradish peroxidase and hydrogen peroxide resulted in the...article 2001