Searched for: subject%3A%22Outcome%22
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Bajard, L. (author), Adamovsky, O. (author), Audouze, K. (author), Baken, K. (author), Barouki, R. (author), Beltman, J. (author), Beronius, A. (author), Bonefeld-Jørgensen, E.C. (author), Cano-Sancho, G. (author), de Baat, M.L. (author), Di Tillio, F. (author), Fernández, M.F. (author), FitzGerald, R.E. (author), Gundacker, C. (author), Hernández, A.F. (author), Hilscherova, K. (author), Karakitsios, S. (author), Kuchovska, E. (author), Long, M. (author), Luijten, M. (author), Majid, S. (author), Marx-Stoelting, P. (author), Mustieles, V. (author), Negi, C.K. (author), Sarigiannis, D. (author), Scholz, S. (author), Sovadinova, I. (author), Stierum, R. (author), Tanabe, S. (author), Tollefsen, K.E. (author), van den Brand, A.D. (author), Vogs, C. (author), Wielsøe, M. (author), Wittwehr, C. (author), Blaha, L. (author)
While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreover, human epidemiological studies with biomarkers of effect (BoE) also play an invaluable role in...
article 2023
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Mokkink, L.B. (author), de Vet, H. (author), Diemeer, S. (author), Eekhout, I. (author)
Simulation studies were performed to investigate for which conditions of sample size of patients (n) and number of repeated measurements (k) (e.g., raters) the optimal (i.e., balance between precise and efficient) estimations of intraclass correlation coefficients (ICCs) and standard error of measurements (SEMs) can be achieved. Subsequently, we...
article 2022
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Terluin, B. (author), Eekhout, I. (author), Terwee, C.B. (author)
Objectives: The anchor-based minimal important change (MIC), based on the receiver operating characteristic (ROC) analysis or predictive modeling, is biased by the proportion of improved patients. The adjusted MIC, published in 2017, adjusts the predictive MIC for this bias but does not take the reliability of the transition ratings (i.e., the...
article 2022
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Regeer, H. (author), van Empelen, P. (author), Bilo, H.J.G. (author), de Koning, E.J.P. (author), Huisman, S.D. (author)
Objective. To examine the relationship between risk factors for low patient activation and change in patient activation, well-being, and health outcomes in people with type 2 diabetes mellitus (T2DM). Method. A longitudinal prospective study was conducted with measurements at baseline and 20-week follow-up among 603 people with T2DM...
article 2022
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Assefi, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Otero, C. (author), Fernandez-Luque, L. (author), Koledova, E. (author), Calliari, L.E. (author)
Background: Recombinant human growth hormone (rhGH) therapy is an effective treatment for children with growth disorders. However, poor outcomes are often associated with suboptimal adherence to treatment. Objective: The easypod connected injection device records and transmits injection settings and dose data from patients receiving rhGH. In...
article 2022
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Naafs, J.C. (author), Marchal, J.P. (author), Fliers, E. (author), Verkerk, P.H. (author), Luijten, M.A.J. (author), Boelen, A. (author), van Trotsenburg, A.S.P. (author), Zwaveling-Soonawala, N. (author)
Context: Early treatment of primary congenital hypothyroidism (CH) prevents irreversible brain damage. Contrary to primary CH, outcome studies on central CH are scarce. Most patients with central CH have multiple pituitary hormone deficiencies (MPHD); these patients are also at risk for neonatal hypoglycemia. Objective: To assess cognitive and...
article 2021
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Austin, P.C. (author), White, I.R. (author), Lee, D.S. (author), van Buuren, S. (author)
Missing data is a common occurrence in clinical research. Missing data occurs when the value of the variables of interest are not measured or recorded for all subjects in the sample. Common approaches to addressing the presence of missing data include complete-case analyses, in which subjects with missing data are excluded, or mean-value...
article 2021
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Brown, F.L. (author), Farag, A.I. (author), Hussein Abd Alla, F. (author), Radford, K. (author), Miller, L. (author), Neijenhuijs, K. (author), Stubbe, H. (author), de Hoop, T. (author), Abbadi Abdullatif, A. (author), Turner, J.S. (author), Jetten, A. (author), Jordans, M.J.D. (author)
Innovations are needed to address the global issue of access to high-quality education, particularly in low- and middle-income countries. This paper shows quasi-experimental evidence that a digital game-based learning programme (‘Can’t Wait to Learn’) led to significantly greater improvements in mathematics competency, Arabic literacy competency...
article 2020
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Moné, M.J. (author), Pallocca, G. (author), Escher, S.E. (author), Exner, T. (author), Herzler, M. (author), Hougaard Bennekou, S. (author), Kamp, H. (author), Kroese, E.D. (author), Leist, M. (author), Steger-Hartmann, T. (author), van de Water, B. (author)
In 2016, the European Commission launched the EU-ToxRisk research project to develop and promote animal-free approaches in toxicology. The 36 partners of this consortium used in vitro and in silico methods in the context of case studies (CSs). These CSs included both compounds with a highly defined target (e.g. mitochondrial respiratory chain...
article 2020
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Pasma, W. (author), Peelen, L.M. (author), van Buuren, S. (author), van Klei, W.A. (author), de Graaff, J.C. (author)
article 2020
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van der Burg, L. (author), Sepriano, A. (author), Landewé, R. (author), Geuskens, G.A. (author), Ottenheijm, R.P.G. (author), Dinant, G.J. (author), Boonen, A. (author)
Objectives: To compare the construct validity of three presenteeism instruments, using health and economic outcomes as external references, among working persons reporting musculoskeletal complaints. Methods: Data from the prospective Study on Transitions in Employment, Ability and Motivation were used. Presenteeism measurement comprised a...
article 2020
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Offerhaus, P. (author), Jans, S (author), Hukkelhoven, C. (author), de Vries, R. (author), Nieuwenhuijze, M. (author)
Background: The maternity care system in the Netherlands is well known for its support of community-based midwifery. However, regular midwifery practices typically do not offer caseload midwifery care - one-to-one continuity of care throughout pregnancy and birth. Because we know very little about the outcomes for women receiving caseload care...
article 2020
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Desprez, B. (author), Birk, B. (author), Blaauboer, B. (author), Boobis, A. (author), Carmichael, P. (author), Cronin, M.T.D. (author), Curie, R. (author), Daston, G. (author), Hubesch, B. (author), Jennings, P. (author), Klaric, M. (author), Kroese, D. (author), Mahony, C. (author), Ouédraogo, G. (author), Piersma, A. (author), Richarz, A.N. (author), Schwarz, M. (author), van Benthem, J. (author), van de Water, B. (author), Vinken, M. (author)
Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this...
article 2019
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van der Pal, S.M. (author), Steinhof, M. (author), Grevinga, M. (author), Wolke, D. (author), Verrips, E. (author)
Background: Several longitudinal cohort studies that follow participants who were born very preterm (VPT) or with a very low birth weight (VLBW) have now gathered outcome data at adult age. The current systematic review aimed to explore whether Health-related Quality of Life (HRQoL) of adults born VPT or VLBW differs from HRQoL of adults born...
article 2019
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Lozano-Ojalvo, D. (author), Benede, S. (author), Antunes, C.M. (author), Bavaro, S.L. (author), Bouchaud, G. (author), Costa, A. (author), Denery-Papini, S. (author), Diaz-Perales, A. (author), Garrido-Arandia, M. (author), Gavrovic-Jankulovic, M. (author), Hayen, S. (author), Martinez-Blanco, M. (author), Molina, E. (author), Monaci, L. (author), Pieters, R.H.H. (author), Villemin, C. (author), Wichers, H.J. (author), Wroblewska, B. (author), Willemsen, L.E.M. (author), Roggen, E.L. (author), van Bilsen, J.H.M. (author)
Background: Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety. We have recently proposed the adverse outcome pathway (AOP) concept to structure the current mechanistic understanding of the...
article 2019
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Rijnders, M.E.B. (author), Jans, S. (author), Aalhuizen, I. (author), Detmar, S. (author), Crone, M. (author)
INTRODUCTION: In response to a relatively high perinatal mortality rate in The Netherlands, the Dutch Health Ministry recommended changes to maternity care, opening a pathway toward more integrated woman-centered services. Because of its potential to positively influence risk factors for adverse pregnancy outcomes, CenteringPregnancy (CP) group...
article 2019
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Versluis, A. (author), van Os-Medendorp, H. (author), Blom, W.M. (author), Michelsen-Huisman, A.D. (author), Castenmiller, J.J.M. (author), Noteborn, H.P.J.M. (author), Houben, G.F. (author), Knulst, A.C. (author)
Background: Cofactors, such as physical exercise and alcohol intake, might be associated with the severity or occurrence of food allergic reactions. Objective: To gain insight into the frequency of presence of potential cofactors in accidental food allergic reactions in adults and to what extent these factors influence the severity and...
article 2019
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Brenninkmeijer, V. (author), Lagerveld, S. (author), Blonk, R.W.B. (author), Schaufeli, W.B. (author), Wijngaards-de Meij, L.D.N.V. (author)
Purpose This study examined who benefits most from a cognitive behavioural therapy (CBT)-based intervention that aims to enhance return to work (RTW) among employees who are absent due to common mental disorders (CMDs) (e.g., depression, anxiety, or adjustment disorder). We researched the influence of baseline work-related self-efficacy and...
article 2019
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Rijnhart, J.J.M. (author), Twisk, J.W.R. (author), Eekhout, I. (author), Heymans, M.W. (author)
BACKGROUND: Logistic regression is often used for mediation analysis with a dichotomous outcome. However, previous studies showed that the indirect effect and proportion mediated are often affected by a change of scales in logistic regression models. To circumvent this, standardization has been proposed. The aim of this study was to show the...
article 2019
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Crone, M.R. (author), Luurssen-Masurel, N. (author), Bruinsma-van Zwicht, B.S. (author), van Lith, J.M.M. (author), Rijnders, M.E.B. (author)
Smoking during pregnancy is associated with a multitude of health behaviors and with the psychosocial and socio-economic circumstances of pregnant women. Limited research has so far been conducted on the clustering of these characteristics and on their effect on pregnancy outcomes. This study aimed to identify different groups of pregnant women...
article 2019
Searched for: subject%3A%22Outcome%22
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