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Fransman, W. (author), Otten, W. (author), Marquart, H. (author), Preuhs, K. (author), Willemsen, J. (author), Boumann, H. (author), Gerritsen, R. (author)Objectives: Within the chemical legislation, REACH was implemented in order to improve safe working conditions with hazardous substances. Literature and real-life experiences by those concerned have shown that there are still gaps with a need for improved risk communication. This study elaborated on how information provided by REACH is...article 2023
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Gart, E. (author), van Duyvenvoorde, W. (author), Snabel, J. (author), de Ruiter, C. (author), Attema, J. (author), Caspers, M.P.M. (author), Lek, S. (author), van Heuven, B.J. (author), Speksnijder, A.G.C.L. (author), Giera, M. (author), Menke, A. (author), Salic, K. (author), Bence, K.K. (author), Tesz, G.J. (author), Keijzer, J. (author), Kleemann, R. (author), Morrison, M.C. (author)Background: NAFLD progression, from steatosis to inflammation and fibrosis, results from an interplay of intra- and extrahepatic mechanisms. Disease drivers likely include signals from white adipose tissue (WAT) and gut. However, the temporal dynamics of disease development remain poorly understood. Methods: High-fat-diet (HFD)-fed Ldlr-/-...article 2023
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Kamijo, T. (author), de Winter, S. (author), Panditha, P. (author), Meulenkamp, E. (author)The transparent conductive electrode (TCE) is a key component of organic light-emitting diodes (OLEDs). High-resolution printed metal grids are a promising alternative to indium tin oxide (ITO). We present results for evaporated OLEDs with a printed copper (Cu) grid with line width below 3 μm. The use of a thick doped hole injection layer (HIL)...article 2022
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de Koning, M.C. (author), Ma, K. (author), van Grol, M. (author), Iordanov, I. (author), Kruijne, M.J.L. (author), Idrees, K.B. (author), Xie, H. (author), Islamoglu, T. (author), Bross, R.P.T. (author), Farha, O.K. (author)In the case of an incident with nerve agents, the timely and ready detection and identification of such a substance on suspected surfaces is essential. However, the detection of low levels of nerve agents on a surface is a considerable challenge for conventional detection equipment, especially with VX, a highly toxic nerve agent with low...article 2022
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Fierloos, I.N. (author), Windhorst, D.A. (author), Fang, Y. (author), Bannink, R. (author), Stam, M. (author), Slijkerman, C.A.A. (author), Jansen, W. (author), Raat, H. (author)Aim: This study examined the association between social support perceived by parents of children aged 1–7 years and the use of additional community youth health care services. Methods: Data of 749 parents of children aged 1–7 years, gathered in the CIKEO cohort study in the Netherlands, were analyzed. Social support was assessed with the...article 2022
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Barciela-Rial, M. (author), Vardon, P.J. (author), van Kessel, T. (author), Griffioen, J. (author), Winterwerp, J.C. (author)Progressively, more dredged sediments are being reused for engineering projects. For example, the Marker Wadden is a new wetland constructed in lake Markermeer, the Netherlands, with dredged cohesive sediments originating from the bed of the lake. Such dredged sediments are often dominated by cohesive sediment particles with varying amounts of...article 2022
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Fattori, M. (author), Cardarelli, S. (author), Fijn, J. (author), Harpe, P. (author), Charbonneau, M. (author), Locatelli, D. (author), Lombard, S. (author), Laugier, C. (author), Tournon, L. (author), Jacob, S. (author), Romanjek, K. (author), Coppard, R. (author), Gold, H. (author), Adler, M. (author), Zirkl, M. (author), Groten, J. (author), Tschepp, A. (author), Lamprecht, B. (author), Postl, M. (author), Stadlober, B. (author), Socratous, J. (author), Cantatore, E. (author)In this work is presented for the first time a large-area proximity sensing surface fabricated by printing organic materials and featuring distributed Analog Frontend Electronics (AFE) based on Organic Thin-Film Transistors (OTFTs). The sensor foil enables detecting the presence of approaching heat sources (like humans or moving machines) at a...article 2022
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van den Hoek, A.M. (author), Özsezen, S. (author), Caspers, M.P.M. (author), van Koppen, A. (author), Hanemaaijer, R. (author), Verschuren, L. (author)The prevalence of non-alcoholic steatohepatitis (NASH) is rapidly increasing and associated with cardiovascular disease (CVD), the major cause of mortality in NASH patients. Although sharing common risk factors, the mechanisms by which NASH may directly contribute to the development to CVD remain poorly understood. The aim of this study is to...article 2022
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Zhang, B. (author), Guo, C. (author), Lin, T. (author), Faaij, A.P.C. (author)Environmental factors, including greenhouse gas (GHG) emissions and soil organic carbon (SOC), should be considered when building a sustainable biofuel supply chain. This work developed a three-step optimization approach integrating a geographical information system-based mixed-integer linear programming model to economically optimize the...article 2022
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Eledlebi, K. (author), Ruta, D. (author), Hildmann, H. (author), Saffre, F. (author), al Hammadi, Y. (author), Isakovic, A.F. (author)When deploying a wireless sensor network (WSN) identifying optimal locations for the nodes is challenging, especially so if the environment is either (i) unknown or (ii) obstacle-rich. We proposes BISON (Bio-Inspired Self-Organizing Network), a variant of the Voronoi algorithm to address this challenge. Among the features of the approach are the...article 2022
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Ma, X. (author), Bin, H. (author), van Gorkom, B.T. (author), van der Pol, T.P.A. (author), Dyson, M.J. (author), Weijtens, C.H.L. (author), Fattori, M. (author), Meskers, S.C.J. (author), van Breemen, A.J.J.M. (author), Tordera, D. (author), Janssen, R.A.J. (author), Gelinck, G.H. (author)Organic bulk heterojunction photodiodes (OPDs) attract attention for sensing and imaging. Their detectivity is typically limited by a substantial reverse bias dark current density (Jd). Recently, using thermal admittance or spectral photocurrent measurements, Jd has been attributed to thermal charge generation mediated by mid-gap states. Here,...article 2022
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Houben, A.J.P. (author), Goldberg, T. (author), Slomp, C.P. (author)The Toarcian Oceanic Anoxic Event (T-OAE, ~183 Ma) represents a well-known episode of organic-rich deposition, which is accompanied by a substantial negative carbon-isotope excursion (CIE). Underpinning the relationships between the carbon-cycle perturbation, ocean anoxia, primary productivity feedbacks and the enrichment of sedimentary organic...article 2021
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Bunting, S.Y. (author), Lapworth, D.J. (author), Crane, E.J. (author), Grima-Olmedo, J. (author), Korosa, A. (author), Kuczynska, A. (author), Mali, N. (author), Rosenqvist, L. (author), van Vliet, M.E. (author), Togola, A. (author), Lopez, B. (author)In Europe, emerging organic compounds (EOCs) in groundwater is a growing research area. Prioritisation for monitoring EOCs in Europe was formalised in 2019 through the development of the first voluntary groundwater watch list (GWWL). Despite this, groundwater occurrence data in the peer reviewed literature for Europe has not been reviewed to...article 2021
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de Braaf, B. (author), Rops, C.M. (author), Storm, C. (author)In atomic layer deposition (ALD), thin layers of materials are deposited on a substrate with atomic layer precision in the vertical direction. The ability to control layer growth in the lateral direction as well is expected to greatly increase the potential of ALD as a path to the bottom-up additive fabrication of electronic devices like solar...article 2021
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van Zomeren, A. (author), Koper, R. (author), Dijkstra, J.J. (author), Comans, R.N.J. (author)Analysis of dissolved organic carbon (DOC) is widely used to quantify the sum of organic carbon species in water. Analyzers based on wet chemical oxidation (WCO) usually have a relatively low detection limit (±1 μg of C/L) and are, therefore, well suited for analyses of DOC in environmental samples (e.g., surface water, groundwater, or seawater)...article 2021
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Akkerman, H. (author), Peeters, B. (author), van Breemen, A. (author), Shanmugam, S. (author), Ugalde Lopez, L. (author), Tordera, D. (author), van de Ketterij, R. (author), Delvitto, E. (author), Malinowski, P. (author), Ke, T.-H. (author), De Roose, F. (author), Moreno Hagelsieb, L. (author), Katsouras, I. (author), Kronemeijer, A.J. (author), Meulenkamp, E. (author), Gelinck, G. (author)In recent years there is an increasing interest to integrate optical sensing in mobile displays, for instance, for biometric fingerprint scanning functionality. There are several routes to incorporate optical fingerprint functionality within the full display area, each with their own benefits and challenges. Here we investigate the different...conference paper 2021
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de Hoogh, I.M. (author), Oosterman, J.E. (author), Otten, W. (author), Krijger, A.M. (author), Berbée-Zadelaar, S. (author), Pasman, W.J. (author), van Ommen, B. (author), Pijl, H. (author), Wopereis, S. (author)Although lifestyle interventions can lead to diabetes remission, it is unclear to what extent type 2 diabetes (T2D) remission alters or improves the underlying pathophysiology of the disease. Here, we assess the effects of a lifestyle intervention on T2D reversal or remission and the effects on the underlying pathology. In a Dutch primary care...article 2021
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Iniguez, B. (author), Nathan, A. (author), Kloes, A. (author), Bonnassieux, Y. (author), Romanjek, K. (author), Charbonneau, M. (author), van der Steen, J.L. (author), Gelinck, G.H. (author), Gneiting, T. (author), Mohamed, F. (author), Ghibaudo, G. (author), Cerdeira, A. (author)We review recent compact modeling solutions for Organic and Amorphous Oxide TFTs (OTFTs and AOS TFTs, respectively), which were developed, under the framework of the EU-funded project DOMINO, to address issues specifically connected to the physics of these devices. In particular, using different approaches, analytical equations were formulated...article 2021
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Donkers, J.M. (author), Eslami Amirabadi, H. (author), van de Steeg, E. (author)Over the past decade, microfluidic intestine-on-a-chip models have been emerging as a novel platform to study intestinal function in health and disease. These microphysiological systems surpass conventional in vitro intestinal model systems, as they add microenvironmental context in the form of mechanical cues or by the incorporation of multiple...article 2021
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Stevens, L.J. (author), Zhu, A.Z.X. (author), Chothe, P.P. (author), Chowdhury, S.K. (author), Donkers, J.M. (author), Vaes, W.H.J. (author), Knibbe, C.A.J. (author), Alwayn, I.P.J. (author), van de Steeg, E. (author)There is a lack of translational preclinical models that can predict hepatic handling of drugs. In this study we aimed to evaluate the applicability of normothermic machine perfusion (NMP) of porcine livers as a novel ex vivo model to predict hepatic clearance, biliary excretion and plasma exposure of drugs. For this evaluation we dosed...article 2021