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Fransman, W. (author), Otten, W. (author), Marquart, H. (author), Preuhs, K. (author), Willemsen, J. (author), Boumann, H. (author), Gerritsen, R. (author)Objectives: Within the chemical legislation, REACH was implemented in order to improve safe working conditions with hazardous substances. Literature and real-life experiences by those concerned have shown that there are still gaps with a need for improved risk communication. This study elaborated on how information provided by REACH is...article 2023
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Gart, E. (author), van Duyvenvoorde, W. (author), Snabel, J. (author), de Ruiter, C. (author), Attema, J. (author), Caspers, M.P.M. (author), Lek, S. (author), van Heuven, B.J. (author), Speksnijder, A.G.C.L. (author), Giera, M. (author), Menke, A. (author), Salic, K. (author), Bence, K.K. (author), Tesz, G.J. (author), Keijzer, J. (author), Kleemann, R. (author), Morrison, M.C. (author)Background: NAFLD progression, from steatosis to inflammation and fibrosis, results from an interplay of intra- and extrahepatic mechanisms. Disease drivers likely include signals from white adipose tissue (WAT) and gut. However, the temporal dynamics of disease development remain poorly understood. Methods: High-fat-diet (HFD)-fed Ldlr-/-...article 2023
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Smyth, T. (author), Deakin, A. (author), Pewter, J. (author), Snee, D. (author), Proud, R. (author), Verbeek, R. (author), Verhagen, V. (author), Paschinger, P. (author), Bell, T. (author), Fishwick, J. (author), Yang, M. (author)Global concerns regarding air quality have over the past decade led to the introduction of regulations by the International Maritime Organisation curbing the emissions of sulphur and nitrogen oxides (SOx, NOx). These limits were implemented initially in so-called “emission control areas”, defined where the density of shipping activity combines...article 2023
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van er Hoeven, I.C. (author), Verreussel, R.M.C.H. (author), Riboulleau, A. (author), Tribovillard, N. (author), van de Schootbrugge, B. (author)Mudstones from the Argiles de Châtillon Formation exposed in the Boulonnais region of Northern France represent a proximal lateral equivalent of the organic-rich Kimmeridge Clay Formation. The Argiles de Châtillon Formation is composed of two subunits that straddle the Kimmeridgian-Tithonian boundary. Each subunit contains an organic-rich...article 2023
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Donkers, J.M. (author), van der Vaart, J.I. (author), van de Steeg, E. (author)The gut plays a key role in drug absorption and metabolism of orally ingested drugs. Additionally, the characterization of intestinal disease processes is increasingly gaining more attention, as gut health is an important contributor to our overall health. The most recent innovation to study intestinal processes in vitro is the development of...article 2023
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von Schneidemesser, E. (author), McDonald, B.C. (author), Denier van der Gon, H.A.C. (author), Crippa, M. (author), Guizzardi, D. (author), Borbon, A. (author), Dominutti, P. (author), Huang, G. (author), Jansens-Maenhout, G. (author), Li, M. (author), Ou-Yang, C.F. (author), Tisinai, S. (author), Wang, J.L. (author)Emission inventories are a critical basis for air quality and climate modeling, as well as policy decisions. Non-methane volatile organic compounds (NMVOCs) are key precursor compounds in ozone and secondary organic aerosol formation. Accurately representing NMVOCs in emission inventories is crucial for understanding atmospheric chemistry, the...article 2023
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Hamzah, N. (author), Höjer Holmgren, K. (author), Åstot, C. (author), van der Schans, M.J. (author), de Reuver, L.P.J. (author), Vanninen, P. (author)The formation of chlorinated organic compounds in concrete debris exposed to reactive chlorine was studied to search for markers specific to chlorine gas exposure. Concrete materials of different origins were exposed to a range of species of reactive chlorine including bleach, humid and dry chlorine gas at different concentrations. Chlorinated...article 2023
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Keuper-Navis, M. (author), Walles, M. (author), Poller, B. (author), Myszczyszyn, A. (author), van der Made, T.K. (author), Donkers, J. (author), Amirabadi, H.E. (author), Wilmer, M.J. (author), Aan, S. (author), Spee, B. (author), Masereeuw, R. (author), van de Steeg, E. (author)Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review, the potential of OoC models to improve the prediction of human oral bioavailability and intrinsic clearance is discussed, with a focus on the functionality of the models and the application...article 2023
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Kamijo, T. (author), de Winter, S. (author), Panditha, P. (author), Meulenkamp, E. (author)The transparent conductive electrode (TCE) is a key component of organic light-emitting diodes (OLEDs). High-resolution printed metal grids are a promising alternative to indium tin oxide (ITO). We present results for evaporated OLEDs with a printed copper (Cu) grid with line width below 3 μm. The use of a thick doped hole injection layer (HIL)...article 2022
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de Koning, M.C. (author), Ma, K. (author), van Grol, M. (author), Iordanov, I. (author), Kruijne, M.J.L. (author), Idrees, K.B. (author), Xie, H. (author), Islamoglu, T. (author), Bross, R.P.T. (author), Farha, O.K. (author)In the case of an incident with nerve agents, the timely and ready detection and identification of such a substance on suspected surfaces is essential. However, the detection of low levels of nerve agents on a surface is a considerable challenge for conventional detection equipment, especially with VX, a highly toxic nerve agent with low...article 2022
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Fierloos, I.N. (author), Windhorst, D.A. (author), Fang, Y. (author), Bannink, R. (author), Stam, M. (author), Slijkerman, C.A.A. (author), Jansen, W. (author), Raat, H. (author)Aim: This study examined the association between social support perceived by parents of children aged 1–7 years and the use of additional community youth health care services. Methods: Data of 749 parents of children aged 1–7 years, gathered in the CIKEO cohort study in the Netherlands, were analyzed. Social support was assessed with the...article 2022
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Barciela-Rial, M. (author), Vardon, P.J. (author), van Kessel, T. (author), Griffioen, J. (author), Winterwerp, J.C. (author)Progressively, more dredged sediments are being reused for engineering projects. For example, the Marker Wadden is a new wetland constructed in lake Markermeer, the Netherlands, with dredged cohesive sediments originating from the bed of the lake. Such dredged sediments are often dominated by cohesive sediment particles with varying amounts of...article 2022
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Fattori, M. (author), Cardarelli, S. (author), Fijn, J. (author), Harpe, P. (author), Charbonneau, M. (author), Locatelli, D. (author), Lombard, S. (author), Laugier, C. (author), Tournon, L. (author), Jacob, S. (author), Romanjek, K. (author), Coppard, R. (author), Gold, H. (author), Adler, M. (author), Zirkl, M. (author), Groten, J. (author), Tschepp, A. (author), Lamprecht, B. (author), Postl, M. (author), Stadlober, B. (author), Socratous, J. (author), Cantatore, E. (author)In this work is presented for the first time a large-area proximity sensing surface fabricated by printing organic materials and featuring distributed Analog Frontend Electronics (AFE) based on Organic Thin-Film Transistors (OTFTs). The sensor foil enables detecting the presence of approaching heat sources (like humans or moving machines) at a...article 2022
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van den Hoek, A.M. (author), Özsezen, S. (author), Caspers, M.P.M. (author), van Koppen, A. (author), Hanemaaijer, R. (author), Verschuren, L. (author)The prevalence of non-alcoholic steatohepatitis (NASH) is rapidly increasing and associated with cardiovascular disease (CVD), the major cause of mortality in NASH patients. Although sharing common risk factors, the mechanisms by which NASH may directly contribute to the development to CVD remain poorly understood. The aim of this study is to...article 2022
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Zhang, B. (author), Guo, C. (author), Lin, T. (author), Faaij, A.P.C. (author)Environmental factors, including greenhouse gas (GHG) emissions and soil organic carbon (SOC), should be considered when building a sustainable biofuel supply chain. This work developed a three-step optimization approach integrating a geographical information system-based mixed-integer linear programming model to economically optimize the...article 2022
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Eledlebi, K. (author), Ruta, D. (author), Hildmann, H. (author), Saffre, F. (author), al Hammadi, Y. (author), Isakovic, A.F. (author)When deploying a wireless sensor network (WSN) identifying optimal locations for the nodes is challenging, especially so if the environment is either (i) unknown or (ii) obstacle-rich. We proposes BISON (Bio-Inspired Self-Organizing Network), a variant of the Voronoi algorithm to address this challenge. Among the features of the approach are the...article 2022
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Ma, X. (author), Bin, H. (author), van Gorkom, B.T. (author), van der Pol, T.P.A. (author), Dyson, M.J. (author), Weijtens, C.H.L. (author), Fattori, M. (author), Meskers, S.C.J. (author), van Breemen, A.J.J.M. (author), Tordera, D. (author), Janssen, R.A.J. (author), Gelinck, G.H. (author)Organic bulk heterojunction photodiodes (OPDs) attract attention for sensing and imaging. Their detectivity is typically limited by a substantial reverse bias dark current density (Jd). Recently, using thermal admittance or spectral photocurrent measurements, Jd has been attributed to thermal charge generation mediated by mid-gap states. Here,...article 2022
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Houben, A.J.P. (author), Goldberg, T. (author), Slomp, C.P. (author)The Toarcian Oceanic Anoxic Event (T-OAE, ~183 Ma) represents a well-known episode of organic-rich deposition, which is accompanied by a substantial negative carbon-isotope excursion (CIE). Underpinning the relationships between the carbon-cycle perturbation, ocean anoxia, primary productivity feedbacks and the enrichment of sedimentary organic...article 2021
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Bunting, S.Y. (author), Lapworth, D.J. (author), Crane, E.J. (author), Grima-Olmedo, J. (author), Korosa, A. (author), Kuczynska, A. (author), Mali, N. (author), Rosenqvist, L. (author), van Vliet, M.E. (author), Togola, A. (author), Lopez, B. (author)In Europe, emerging organic compounds (EOCs) in groundwater is a growing research area. Prioritisation for monitoring EOCs in Europe was formalised in 2019 through the development of the first voluntary groundwater watch list (GWWL). Despite this, groundwater occurrence data in the peer reviewed literature for Europe has not been reviewed to...article 2021
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de Braaf, B. (author), Rops, C.M. (author), Storm, C. (author)In atomic layer deposition (ALD), thin layers of materials are deposited on a substrate with atomic layer precision in the vertical direction. The ability to control layer growth in the lateral direction as well is expected to greatly increase the potential of ALD as a path to the bottom-up additive fabrication of electronic devices like solar...article 2021