Searched for: subject%3A%22Organ%255C%2BCulture%255C%2BTechniques%22
(1 - 6 of 6)
document
Schepers, A. (author), Eefting, D. (author), Bonta, P.I. (author), Grimbergen, J.M. (author), de Vries, M.R. (author), van Weel, V. (author), de Vries, C.J. (author), Egashira, K. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE - Because late vein graft failure is caused by intimal hyperplasia (IH) and accelerated atherosclerosis, and these processes are thought to be inflammation driven, influx of monocytes is one of the first phenomena seen in IH, we would like to provide direct evidence for a role of the MCP-1 pathway in the development of vein graft...
article 2006
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Zuang, V. (author), Alonso, M.A. (author), Botham, P.A. (author), Eskes, C. (author), Fentem, J. (author), Liebsch, M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
article 2005
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van Beek, E.R. (author), Cohen, L.H. (author), Leroy, I.M. (author), Ebetino, F.H. (author), Löwik, C.W.G.M. (author), Papapoulos, S.E. (author), Gaubius Instituut TNO (author)
Bisphosphonates (BPS) inhibit bone resorption and are divided into two classes according to their chemical structure and mechanism of action: nonnitrogen containing BPS such as etidronate and clodronate that are of low potency and inhibit osteoclast function via metabolism into toxic ATP-metabolites and nitrogen-containing BPS (NBPS), such as...
article 2003
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Quax, P.H.A. (author), Lamfers, M.L.M. (author), Lardenoye, J.H.P. (author), Grimbergen, J.M. (author), de Vries, M.R. (author), Slomp, J. (author), de Ruiter, M.C. (author), Kockx, M.M. (author), Verheijen, J.H. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
Background - Smooth muscle cell migration, in addition to proliferation, contributes to a large extent to the neointima formed in humans after balloon angioplasty or bypass surgery. Plasminogen activator/plasmin-mediated proteolysis is an important mediator of this smooth muscle cell migration. Here, we report the construction of a novel hybrid...
article 2001
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Olinga, P. (author), Groen, K. (author), Hof, I.H. (author), de Kanter, R. (author), Koster, H.J. (author), Leeman, W.R. (author), Rutten, A.A.J.J.L. (author), van Twillert, K. (author), Groothuis, G.M.M. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Precision-cut liver slices are presently used for various research objects, e.g. to study metabolism, transport, and toxicity of xenobiotics. Various incubation systems are presently employed, but a systematic comparison between these incubation systems with respect to preservation of slice function has not been performed yet. Therefore, we...
article 1997
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Slomp, J. (author), de Gittenberger - Groot, A.C. (author), van Munsteren, J.C. (author), Huysmans, H.A. (author), van Bockel, J.H. (author), van Hinsbergh, V.W.M. (author), Poelmann, R.E. (author), Gaubius Instituut TNO (author)
Intimal proliferation is a characteristic feature of arteriosclerosis. Whole vessel wall organ culture systems have been developed to study the early stages of neointima formation. We have cultured a large number of explants of human saphenous vein specimens for several weeks, and have identified the nature of the cells in the newly formed...
article 1996
Searched for: subject%3A%22Organ%255C%2BCulture%255C%2BTechniques%22
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