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Gelbke, H.P. (author), Buist, H. (author), Eisert, R. (author), Leibold, E. (author), Sherman, J. (author)Polyoxymethylene (POM) is a polymer of formaldehyde used inter alia for kitchenware and food processing machines. By migration into food, consumers may be exposed to small additional amounts of formaldehyde in food. In order to address such potential exposures, Specific Migration Limits are derived using all studies with oral exposure in mammals...article 2019
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Walczak, A.P. (author), Hendriksen, P.J.M. (author), Woutersen, R.A. (author), van der Zande, M. (author), Undas, A.K. (author), Helsdingen, R. (author), van den Berg, H.H.J. (author), Rietjens, I.M.C.M. (author), Bouwmeester, H. (author)The likelihood of oral exposure to nanoparticles (NPs) is increasing, and it is necessary to evaluate the oral bioavailability of NPs. In vitro approaches could help reducing animal studies, but validation against in vivo studies is essential. Previously, we assessed the translocation of 50 nm polystyrene NPs of different charges (neutral,...article 2015
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van der Zande, M. (author), Vandebriel, R.J. (author), Groot, M.J. (author), Kramer, E. (author), Herrera Rivera, Z.E. (author), Rasmussen, K. (author), Ossenkoppele, J.S. (author), Tromp, P. (author), Gremmer, E.R. (author), Peters, R.J.B. (author), Hendriksen, P.J. (author), Marvin, H.J.P. (author), Hoogenboom, R.L.A.P. (author), Peijnenburg, A.A.C.M. (author), Bouwmeester, H. (author)Background: Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 - 200 nm) up...article 2014
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Tluczkiewicz, I. (author), Buist, H.E. (author), Martin, M.T. (author), Mangelsdorf, I. (author), Escher, S.E. (author)The present report describes a strategy to refine the current Cramer classification of the TTC concept using a broad database (DB) termed TTC RepDose. Cramer classes 1-3 overlap to some extent, indicating a need for a better separation of structural classes likely to be toxic, moderately toxic or of low toxicity.Groups of structurally similar...article 2011
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Zijlstra, N. (author), Mars, M. (author), Stafleu, A. (author), de Graaf, C. (author), TNO Kwaliteit van Leven (author)This study explored the effect of texture differences on satiation (ad libitum food intake) in 3 pairs of solid foods. Test products were specially developed luncheon meat, meat replacers and sweets. Each food consisted of a " hard" and " soft" version, expected to lead to different eating rates and consequently to differences in oral sensory...article 2010