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Michaud, P.A. (author), Visser, A. (author), Vervoort, J.P.M. (author), Kocken, P. (author), Reijneveld, S.A. (author), Blair, M. (author), Rigby, M. (author), Weber, M. (author), Jansen, D. (author)Background and objectives Adolescent sexual and reproductive health and rights (SRHR) are of particular relevance given their potential short-term or long-term health consequences. This study evaluates recommendations and policies regarding access to care in this area in 31 European countries (European Union (EU) plus Iceland, Norway and...article 2020
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Borgdorff, H. (author), Verwijs, M.C. (author), Wit, F.W.N.M. (author), Tsivtsivadze, E. (author), Ndayisaba, G.F. (author), Verhelst, R. (author), Schuren, F.H. (author), van de Wijgert, J.H.H.M. (author)Background The observed association between Depo-Provera injectable use and increased HIV acquisition may be caused by hormone-induced increased susceptibility to other sexually transmitted infections (STIs) or changes in the cervicovaginal microbiota (VMB), accompanied by genital immune activation and/or mucosal remodeling. Methods Rwandan...article 2015
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TNO Kwaliteit van Leven (author), Gautam, R. (author), Borgdorff, H. (author), Jespers, V. (author), Francis, S.C. (author), Verhelst, R. (author), Mwaura, M. (author), Delany-Moretlwe, S. (author), Ndayisaba, G. (author), Kyongo, J.K. (author), Hardy, L. (author), Menten, HJ. (author), Crucitti, T. (author), Tsivtsivadze, E. (author), Schuren, F. (author), van de Wijgert, J.H.R.M. (author), Vaginal biomarkers Study Group, (author)Background: Sociodemographic, behavioral and clinical correlates of the vaginal microbiome (VMB) as characterized by molecular methods have not been adequately studied. VMB dominated by bacteria other than lactobacilli may cause inflammation, which may facilitate HIV acquisition and other adverse reproductive health outcomes. Methods: We...article 2015
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Rad, M. (author), Kluft, C. (author), de Kam, M.L. (author), Meijer, P. (author), Cohen, A.F. (author), Grubb, G.S. (author), Constantine, G.D. (author), Burggraaf, J. (author)Objectives?To compare the effects of a combined oral contraceptive (COC) taken continuously with those of one of similar composition taken cyclically on 30 variables related to haemostasis, lipids, carbohydrates, bone metabolism, and sex hormone-binding globulin (SHBG). Methods?Randomised, open-label, multicentre, comparative substudy of a...article 2011
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van Wouwe, J.P. (author), Lanting, C.I. (author), van Dommelen, P. (author), Treffers, P.E. (author), van Buuren, S. (author), TNO Kwaliteit van Leven (author)Aim: The aim of this study was to gain insight into contraception practised and related to breastfeeding duration. Methods: Mothers with infants up to 6 months received a questionnaire on infant feeding (breast or formula feeding) and contraception (hormonal or non-hormonal methods). Estimates of the time interval between resuming contraception...article 2009
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Kluft, C. (author), Meijer, P. (author), LaGuardia, K.D. (author), Fisher, A.C. (author), TNO Kwaliteit van Leven (author)Purpose: The aim of this study was to compare effects of the transdermal contraceptive patch, a desogestrel/ethinyl estradiol (EE)-containing, monophasic combination oral contraceptive (COC) and a levonorgestrel/EE-containing, triphasic COC on hemostasis variables. Study Design: This was a randomized, open-label study of 104 young women who...article 2008
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de Lange, M. (author), de Geus, E.J.C. (author), Kluft, C. (author), Meijer, P. (author), van Doornen, L.J.P. (author), Boomsma, D.I. (author), Snieder, H. (author), TNO Kwaliteit van Leven (author)Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in...article 2006
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Rad, M. (author), Kluft, C. (author), Ménard, J. (author), Burggraaf, J. (author), de Kam, M.L. (author), Meijer, P. (author), Sivin, I. (author), Sitruk-Ware, R.L. (author), TNO Kwaliteit van Leven (author)Objective: This study aimed to compare the effects on hemostasis variables of a contraceptive vaginal ring with those of an oral contraceptive. Study design: Twenty-three and 22 healthy premenopausal women were randomized to the contraceptive vaginal ring (150 μg Nestorone and 15 μg ethinyl estradiol) or Stediril 30 during 3 cycles. Analysis of...article 2006
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Kluft, C. (author), Endrikat, J. (author), Mulder, S.M. (author), Gerlinger, C. (author), Heithecker, R. (author), TNO Kwaliteit van Leven (author)Purpose: In this open-label, randomized study, we assessed the effects on hemostasis of two combined oral contraceptives containing drospirenone (DRSP) as progestogen component. Methods: Three milligrams of DRSP, a progestogen with antimineralocorticoid activity, was combined with either 30 or 20 μg ethinyl estradiol (EE) (DRSP/30EE; DRSP/20EE)...article 2006
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TNO Kwaliteit van Leven TNO Voeding (author), Genkinger, J.M. (author), Hunter, D.J. (author), Spiegelman, D. (author), Anderson, K.E. (author), Buring, J.E. (author), Freudenheim, J.L. (author), Goldbohm, R.A. (author), Harnack, L. (author), Hankinson, S.E. (author), Larsson, S.C. (author), Leitzmann, M. (author), McCullough, M.L. (author), Marshall, J. (author), Miller, A.B. (author), Rodriguez, C. (author), Rohan, T.E. (author), Schatzkin, A. (author), Schouten, L.J. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author)Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating...article 2006
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TNO Kwaliteit van Leven TNO Preventie en Gezondheid (author), Maat, M.P.M.de (author), Bladbjerg, E.M. (author), Kluft, C. (author), Winkler, U.H. (author), Rekers, H. (author), Skouby, S.O. (author), Jespersen, J. (author)Background: Administration of oral contraceptives (OCs) has profound effects on the plasma levels of haemostasis and inflammation variables, resulting in an increased thrombosis risk. Individuals show large differences in the response of these variables to OCs. Polymorphism in the estrogen receptor-1 (ER1) gene may explain part of this inter...article 2006
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Schouten, L.J. (author), Zeegers, M.P.A. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To study alcohol consumption in relation to ovarian cancer risk in a prospective cohort study. Methods: The Netherlands Cohort Study on diet and cancer was initiated in 1986. A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 62,573 postmenopausal women. Follow-up for cancer was...article 2004
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Witte, D.R. (author), Broekmans, W.M.R. (author), Kardinaal, A.F.M. (author), Klöpping-Ketelaars, I.A.A. (author), van Poppel, G. (author), Bots, M.L. (author), Kluft, C. (author), Princen, J.M.G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Background: Flow mediated dilatation (FMD) of the brachial artery and soluble intercellular adhesion molecule 1 (sICAM-1) are measures of distinct functions of the endothelium, reflecting nitric oxide (NO)-mediated and pro-inflammatory status, respectively. The comparative value of the two measures in relation to cardiovascular risk is unknown....article 2003
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Riese, H. (author), Houtman, I.L.D. (author), Doornen, L.J.P. (author), de Geus, E.J.C. (author)This study examined the possible effects of job demands, decision latitude, and job-related social support on risk indicators for cardiovascular disease (CVD) in 165 female nurses. Job strain was measured with the Job Content Questionnaire; CVD risk was measured with insulin, total cholesterol, triglyceride (TG), high-density lipoprotein...article 2000
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Kluft, C. (author), de Maat, M.P.M. (author), Heinemann, L.A.J. (author), Spannagl, M. (author), Schramm, W. (author), Gaubius instituut TNO (author)Combined oral contraceptives show clear differences in effect on the tissue factor-initiated coagulation test of activated protein C resistance, which is dependent on the presence and dosage of levonorgestrel. Multiphasic levonorgestrol oral contraceptives differ from monophasic contraceptives and resemble third-generation contraceptives. The...article 1999
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van Hooff, M.H.A. (author), Hirasing, R.A. (author), Kaptein, M.B.M. (author), Koppenaal, C. (author), Voorhorst, F.J. (author), Schoemaker, J. (author), TNO Preventie en Gezondheid (author)Background. Oral contraceptives are prescribed as contraception but also as therapy for menstrual cycle disturbances and acne. We studied the prevalence of oral contraceptive (OC) use and the indications to start OC use among adolescents. Methods. A cohort consisting of ninth grade secondary school girls (mean age 15.3 ± 0.6 (s.d.) years)...article 1998
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Massé, P.G. (author), van den Berg, H. (author), Livingstone, M.M. (author), Duguay, C. (author), Beaulieu, G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)The present study was aimed to assess the psychological status of young healthy women after the administration of a triphasic contraceptive steroid preparation for six complete menstrual cycles. Subjects had never used oral contraceptives (OC) and had neither a familial history of depression nor psychological disturbances. OC-induced...article 1998
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Kluft, C. (author), Lansink, M. (author), Gaubius Instituut TNO (author)Combined oral contraceptives (COCs) have effects on a large number of haemostasis variables. We have summarised literature data on effects of COCs containing 30-35 μg ethinyl estradiol for the third generation of progestogens (PGs): desogestrel, gestodene and norgestimate. It is concluded that about 15 variables show a shift in distribution of...article 1997
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Massé, P.G. (author), van den Berg, H. (author), Duguay, C. (author), Beaulieu, G. (author), Simard, J.M. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The objectives of the study were to follow-up six artificial menstrual cycles induced by Triphasil® in order to determine: 1) the time of apparition of B6 metabolic side-effects, in the eventuality they occur, and 2) the existence or non-existence of a normalization process and if so, when it is initiated. The choice of this triphasic OC...article 1996
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- Bloemenkamp, K.W.M. (author), Gevers Leuven, J.A. (author), Helmerhorst, F.M. (author), Dersjant-Roorda, M.C. (author), de Boer, R. (author), Meyer, P. (author), Spielmann, D. (author), Kluft, C. (author), Gaubius Instituut TNO (author) article 1996
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