- document
-
Zaadstra, B.M. (author), Chorus, A.M.J. (author), van Buuren, S. (author), Kalsbeek, H. (author), van Noort, J.M. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author), DenV KvL (author)Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population...article 2008
- document
-
Boomsma, D.I. (author), Willemsen, G. (author), Sullivan, P.F. (author), Heutink, P. (author), Meijer, P. (author), Sondervan, D. (author), Kluft, C. (author), Smit, G. (author), Nolen, W.A. (author), Zitman, F.G. (author), Smit, J.H. (author), Hoogendijk, W.J. (author), van Dyck, R. (author), de Geus, E.J.C. (author), Penninx, B.W.J.H. (author), TNO Kwaliteit van Leven (author)To identify the genomic regions that confer risk and protection for major depressive disorder (MDD) in humans, large-scale studies are needed. Such studies should collect multiple phenotypes, DNA, and ideally, biological material that allows gene expression analysis, transcriptomic, proteomic, and metabolomic studies. In this paper, we briefly...article 2008
- document
-
Orešič, M. (author), Clish, C.B. (author), Davidov, E.J. (author), Verheij, E. (author), Vogels, J. (author), Havekes, L.M. (author), Neumann, E. (author), Adourian, A. (author), Naylor, S. (author), van der Greef, J. (author), Plasterer, T. (author), TNO Preventie en Gezondheid (author)Multifactorial diseases present a significant challenge for functional genomics. Owing to their multiple compartmental effects and complex biomolecular activities, such diseases cannot be adequately characterised by changes in single components, nor can pathophysiological changes be understood by observing gene transcripts alone. Instead, a...article 2004
- document
-
Lüchtenborg, M. (author), Weijenberg, M.P. (author), Roemen, G.M.J.M. (author), de Bruïne, A.P. (author), van den Brandt, P.A. (author), Lentjes, M.H.F.M. (author), Brink, M. (author), van Engeland, M. (author), Goldbohm, R.A. (author), de Goeij, A.F.P.M. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The adenomatous polyposis coli (APC) gene is considered to be a gatekeeper in colorectal tumourigenesis. Inactivating mutations in APC have been reported in 34-70% of sporadic colorectal cancer patients, the majority of which occur in the mutation cluster region (MCR). In this study, tumour tissue from 665 incident colorectal cancer patients,...article 2004
- document
-
Bank, R.A. (author), Verzijl, N. (author), Lafeber, F.P.J.G. (author), Tekoppele, J.M. (author), Gaubius instituut TNO TNO Preventie en Gezondheid (author)Objective: The collagen network in human articular cartilage experiences a large number of stress cycles during life as it shows hardly any turnover after adolescence. We hypothesized that, to withstand fatigue failure, the physical condition of the collagen network laid down at adolescence is of crucial importance for the age of onset of...article 2002
- document
- van Wouwe, J.P. (author), Verkerk, P.H. (author), Mattiazzo, G.F. (author), El Mokadem, N. (author), Hirasing, R.A. (author) article 2002