Searched for: subject%3A%22Occupational%255C%2Bexposure%255C%2Blimits%22
(1 - 6 of 6)
document
McKee, R.H. (author), Lammers, J.H.C.M. (author), Muijser, H. (author), Owen, D.E. (author), Kulig, B.M. (author), TNO Kwaliteit van Leven (author)
This article reports the results of neurobehavioral tests on representative aromatic constituents, specifically C<sub>9</sub> to C<sub>11</sub> species. The testing evaluated effects in several domains including clinical effects, motor activity, functional observations, and visual discrimination performance. Exposures ranging from 600 to 5000 mg...
article 2010
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Hissink, A.M. (author), Kulig, B.M. (author), Kruse, J. (author), Freidig, A.P. (author), Verwei, M. (author), Muijser, H. (author), Lammers, J.H.C.M. (author), Mckee, R.H. (author), Owen, D.E. (author), Sweeney, L.M. (author), Salmon, F. (author), TNO Kwaliteit van Leven (author)
This report describes a physiologically based pharmacokinetic model for cyclohexane and its use in comparing internal doses in rats and volunteers following inhalation exposures. Parameters describing saturable metabolism of cyclohexane are measured in rats and used along with experimentally determined partition coefficients. The model is...
article 2009
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Hissink, A.M. (author), Kr├╝se, J. (author), Kulig, B.M. (author), Verwei, M. (author), Muijser, H. (author), Salmon, F. (author), Leenheers, L.H. (author), Owen, D.E. (author), Lammers, J.H.C.M. (author), Freidig, A.P. (author), McKee, R.H. (author), TNO Kwaliteit van Leven (author)
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in rats and human volunteers in which acute CNS effects were measured and toxicokinetic data were collected. A complex hydrocarbon solvent, white...
article 2007
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van Helden, H.P.M. (author), Trap, H.C. (author), Oostdijk, J.P. (author), Kuijpers, W.C. (author), Langenberg, J.P. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
Realistic scenarios for low-level exposure to nerve agents will often involve exposures over several hours to extremely low doses of agent. In order to expose animals to the lowest controllable concentrations of agent and to increase exposure times until a lowest observable effect level (LOEL) becomes measurable, a validated system was developed...
article 2003
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Seeley, M.R. (author), Tonner-Navarro, L.E. (author), Beck, B.D. (author), Deskin, R. (author), Feron, V.J. (author), Johanson, G. (author), Bolt, H.M. (author)
This report compares cancer classification systems, health risk assessment approaches, and procedures used for establishing occupational exposure limits (OELs), in various European countries and scientific organizations. The objectives were to highlight and compare key aspects of these processes and to identify the basis for differences in...
article 2001
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Bos, P.M.J. (author), Brouwer, D.H. (author), Stevenson, H. (author), Hoogendoorn, L. (author), Boogaard, P.J. (author), de Kort, W.L.A.M. (author), van Hemmen, J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Objective. To evaluate two different techniques for assessing dermal exposure to 4,4'-methylene dianiline (MDA) in a field study. The results were used to test the applicability of a recently proposed quantitative dermal occupational exposure limit (DOEL) for MDA in a workplace scenario. Methods. For two consecutive weeks six workers were...
article 1998
Searched for: subject%3A%22Occupational%255C%2Bexposure%255C%2Blimits%22
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