Searched for: subject%3A%22Occupational%255C%2BExposure%22
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Scholten, B. (author), Portengen, L. (author), Pronk, A. (author), Stierum, R. (author), Downward, G.S. (author), Vlaanderen, J. (author), Vermeulen, R. (author)
Background: Chemical risk assessment can benefit from integrating data across multiple evidence bases, especially in exposure–response curve (ERC) modeling when data across the exposure range are sparse. Methods: We estimated the ERC for benzene and acute myeloid leukemia (AML), by fitting linear and spline-based Bayesian meta-regression models...
article 2022
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Pronk, A. (author), Loh, M. (author), Kuijpers, E. (author), Albin, M. (author), Selander, J. (author), Godderis, L. (author), Ghosh, M. (author), Vermeulen, R. (author), Peters, S. (author), Sivesind Mehlum, I. (author), Turner, M. (author), Schlunssen, V. (author), Goldberg, M. (author), Kogevinas, M. (author), Harding, B. (author), Solovieva, S. (author), Garani-Papadatos, T. (author), van Tongeren, M. (author), Stierum, R. (author)
Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all...
article 2022
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Huuskonen, P. (author), Karakitsios, S. (author), Scholten, B. (author), Westerhout, J. (author), Sarigiannis, D.A. (author), Santonen, T. (author)
The aim of this work was to demonstrate how human biomonitoring (HBM) data can be used to assess cancer risks for workers and the general population. Ortho-toluidine, OT (CAS 95-53-4) is an aniline derivative which is an animal and human carcinogen and may cause methemoglobinemia. OT is used as a curing agent in epoxy resins and as intermediate...
article 2022
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Schlüter, U. (author), Arnold, S. (author), Borghi, F. (author), Cherrie, J. (author), Fransman, W. (author), Heussen, H. (author), Jayjock, M. (author), Jensen, K.A. (author), Koivisto, J. (author), Koppisch, D. (author), Meyer, J. (author), Spinazzè, A. (author), Tanarro, C. (author), Verpaele, S. (author), von Goetz, N. (author)
On 20 October 2020, the Working Group “Exposure Models” of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe) organised an online workshop to discuss the theoretical background of models for the assessment of occupational exposure to chemicals. In this report, participants of the workshop with an active...
article 2022
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le Feber, M. (author), Jadoenathmisier, T. (author), Goede, H. (author), Kuijpers, E. (author), Pronk, A. (author)
Will sensor-based exposure assessment be the future in workplace settings? Static instruments with embedded sensors are already applied to monitor levels of dangerous substances-in the context of acute health effects-at critical locations. However, with wearable, lightweight, miniaturized (low-cost) sensors developing quickly, much more is...
article 2021
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Nunez, J. (author), Koldeweij, R. (author), Trimboli, J. (author), Boersma, A. (author)
In this work, a particulate matter (PM) sensor based on infrared spectroscopy is presented and evaluated for its use in occupational exposure. The technology is able to chemically identify the components of aerosols and provide quantitative information about the presence of crystalline silica, which is widely considered to be a health concern at...
conference paper 2021
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Ghosh, M. (author), Janssen, L. (author), Martens, D.S. (author), Öner, D. (author), Vlaanderen, J. (author), Pronk, A. (author), Kuijpers, E. (author), Vermeulen, R. (author), Nawrot, T.S. (author), Godderis, L. (author), Hoet, P.H. (author)
Carbon nanotubes (CNTs) except MWCNT-7 have been classified as Group 3 ["Not classifiable as to its carcinogenicity to humans"] by the IARC. Despite considerable mechanistic evidence in vitro/in vivo, the classification highlights a general lack of data, especially among humans. In our previous study, we reported epigenetic changes in the MWCNT...
article 2020
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Savic, N. (author), Gasic, B. (author), Schinkel, J. (author), Vernez, D. (author)
The Advanced REACH Tool (ART) is the most sophisticated tool used for evaluating exposure levels under the European Union's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulations. ART provides estimates at different percentiles of exposure and within different confidence intervals (CIs). However, its performance...
article 2018
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Fransman, W. (author)
[No abstract available]
article 2018
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Koivisto, A.J. (author), Kling, K.I. (author), Fonseca, A.S. (author), Brostrøm Bluhme, A. (author), Moreman, M. (author), Yu, M. (author), Costa, A.L. (author), Giovanni, B. (author), Ortelli, S. (author), Fransman, W. (author), Vogel, U. (author), Jensen, K.A. (author)
Nanoscale TiO2 (nTiO2) is manufactured in high volumes and is of potential concern in occupational health. Here, we measured workers exposure levels while ceramic honeycombs were dip coated with liquid photoactive nanoparticle suspension and dried with an air blade. The measured nTiO2 concentration levels were used to assess process specific...
article 2018
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Fonseca, A.S. (author), Kuijpers, E. (author), Kling, K.I. (author), Levin, M. (author), Koivisto, A.J. (author), Nielsen, S.H. (author), Fransman, W. (author), Fedutik, Y. (author), Jensen, K.A. (author), Koponen, I.K. (author)
Fume hoods are one of the most common types of equipment applied to reduce the potential of particle exposure in laboratory environments. A number of previous studies have shown particle release during work with nanomaterials under fume hoods. Here, we assessed laboratory workers’ inhalation exposure during synthesis and handling of CuO, TiO2...
article 2018
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Niks, I.M.W. (author), Gevers, J.M.P. (author), de Jonge, J. (author), Houtman, I.L.D. (author)
Effective interventions to prevent work stress and to improve health, well-being, and performance of employees are of the utmost importance. This quasi-experimental intervention study presents a specific method for diagnosis of psychosocial risk factors at work and subsequent development and implementation of tailored work stress interventions,...
article 2018
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Goede, H. (author), de Vries, Y.C. (author), Kuijpers, E. (author), Fransman, W. (author)
This review describes an evaluation of the effectiveness of Risk Management Measures (RMM) for nanomaterials in the workplace. Our aim was to review the effectiveness of workplace RMM for nanomaterials and to determine whether established effectiveness values of conventional chemical substances applied for modelling purposes should be adopted or...
article 2018
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Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Richard Glass, C. (author), Charistou, A.N. (author), Anastassiadou, P. (author), Gerritsen-Ebben, R. (author), Machera, K. (author)
A dislodgeable foliar residue study was conducted in greenhouse pepper and tomato on the island of Crete, Greece, following the spray application of an SC insecticide (with active substance (a.s.) tebufenozide) and an EC fungicide (a.s. bupirimate). Furthermore, for the assessment of worker exposure to pesticides – as a result of re-entering the...
article 2017
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Kuijpers, E. (author), Bekker, C. (author), Brouwer, D. (author), le Feber, M. (author), Fransman, W. (author)
Exposure assessment for nano-objects, and their aggregates and agglomerates (NOAA), has evolved from explorative research toward more comprehensive exposure assessment, providing data to further develop currently used conservative control banding (CB) tools for risk assessment. This study aims to provide an overview of current knowledge on...
article 2017
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Vlaanderen, J. (author), Pronk, A. (author), Rothman, N. (author), Hildesheim, A. (author), Silverman, D. (author), Hosgood, H.D. (author), Spaan, S. (author), Kuijpers, E. (author), Godderis, L. (author), Hoet, P. (author), Lan, Q. (author), Vermeulen, R. (author)
Background: Multi-wall carbon nanotubes (MWCNTs) are manufactured nanomaterials to which workers and the general population will be increasingly exposed in coming years. Little is known about potential human health effects of exposure to MWCNTs, but effects on the lung and the immune system have been reported in animal and mechanistic studies....
article 2017
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Bekker, C. (author), Fransman, W. (author), Boessen, R. (author), Oerlemans, A. (author), Ottenbros, I.B. (author), Vermeulen, R. (author)
Background: Nano-specific inhalation exposure models could potentially be effective tools to assess and control worker exposure to nano-objects, and their aggregates and agglomerates (NOAA). However, due to the lack of reliable and consistent collected NOAA exposure data, the scientific basis for validation of the existing NOAA exposure models...
article 2017
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Ghosh, M (author), Oner, D. (author), Poels, K. (author), Tabish, A.M. (author), Vlaanderen, J. (author), Pronk, A. (author), Kuijpers, E. (author), Lan, Q. (author), Vermeulen, R. (author), Bekaert, B. (author), Hoet, P.H.M. (author), Godderis, L. (author)
This study was designed to assess the epigenetic alterations in blood cells, induced by occupational exposure to multi-wall carbon nanotubes (MWCNT). The study population comprised of MWCNT-exposed workers (n=24) and unexposed controls (n=43) from the same workplace. We measured global DNA methylation/hydroxymethylation levels on the 5th...
article 2017
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Szigeti, T. (author), Dunster, C. (author), Cattaneo, A. (author), Cavallo, D. (author), Spinazze, A. (author), Saraga, D.E. (author), Sakellaris, I.A. (author), de Kluizenaar, Y. (author), Cornelissen, E.J.M. (author), Hanninen, O. (author), Peltonen, M. (author), Calzolai, G. (author), Lucarelli, F. (author), Mandin, C. (author), Bartzis, J.G. (author), Zaray, G. (author), Kelly, F.J. (author)
In the frame of the OFFICAIR project, indoor and outdoor PM2.5 samples were collected in office buildings across
article 2016
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Kurt, R.E. (author), Khalid, H. (author), Turan, O. (author), Houben, M. (author), Bos, J. (author), Helvacioglu, I.H. (author)
With modern trends of decrease in crew numbers on board ships together with increased operational demands and paperwork, crew fatigue and comfort have become more critical and are being given more importance. It is well known that environmental factors affect crew comfort and performance. The two outstanding factors which exist in the shipboard...
article 2016
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