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Vreeken, D. (author), Seidel, F. (author), de La Roij, G. (author), Vening, W. (author), den Hengst, W.A. (author), Verschuren, L. (author), Özsezen, S. (author), Kessels, R.P.C. (author), Duering, M. (author), Mutsaerts, H.J.M.M. (author), Kleemann, R. (author), Wiesmann, M. (author), Hazebroek, E.J. (author), Kiliaan, A.J. (author)BACKGROUND AND OBJECTIVE: While underlying pathophysiology linking obesity to brain health is not completely understood, white adipose tissue (WAT) is considered a key player. In obesity, WAT becomes dysregulated, showing hyperplasia, hypertrophy, and eventually inflammation. This disbalance leads to dysregulated secretion of adipokines...article 2023
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Vreeken, D. (author), Seidel, F. (author), Custers, E.M. (author), Olsthoorn, L. (author), Cools, S. (author), Aarts, E.O. (author), Kleemann, R. (author), Kessels, R. (author), Weismann, M. (author), Hazebroek, E.J. (author), Killiaan, A.J. (author)Importance: Bariatric surgery-induced weight loss is often associated with improved cognitive function. However, improvement in cognitive function is not always exhibited by all patients, and the mechanisms behind cognitive improvement remain unknown. Objective: To investigate the association of changes in adipokines, inflammatory factors, mood,...article 2023
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Seidel, F. (author), Fluiter, K. (author), Kleemann, R. (author), Worms, N. (author), van Nieuwkoop, A. (author), Caspers, M.P.M. (author), Grigoriadis, N. (author), Kiliaan, A.J. (author), Baas, F. (author), Michailidou, I. (author), Morrison, M.C. (author)Introduction: Obesity has been linked to vascular dysfunction, cognitive impairment and neurodegenerative diseases. However, experimental models that recapitulate brain pathology in relation to obesity and vascular dysfunction are still lacking. Methods: In this study we performed the histological and histochemical characterization of brains...article 2023
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Morrison, M.C. (author), Egelandsdal, B. (author), Harvei, S. (author), Rocha, S.D.C. (author), Pieterman, E.J. (author), Kleemann, R. (author), Carlsen, H. (author)Cardiovascular disease (CVD) is closely associated with obesity through risk factors such as dyslipidemia and chronic low-grade inflammation, which may be affected by diet. Dietary fats have been extensively studied in relation to CVD risk, however these studies have not always yielded consistent results, most likely due to lack in control of...article 2023
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Seidel, F. (author), Fluiter, K. (author), Kleemann, R. (author), Worms, N. (author), van Nieuwkoop, A. (author), Caspers, M.P.M. (author), Grigoriadis, N. (author), Kiliaan, A.J. (author), Baas, F. (author), Michailidou, I. (author), Morrison, M.C. (author)[This corrects the article DOI: 10.3389/fncel.2023.1205261.]article 2023
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Blaauwendraad, S.M. (author), Stevens, D.R. (author), van den Dries, M.A. (author), Gaillard, R. (author), Pronk, A. (author), Spaan, S. (author), Ferguson, K.K. (author), Jaddoe, V.W.V. (author)BACKGROUND: Fetal exposure to organophosphate (OP) pesticides might lead to fetal metabolic adaptations, predisposing individuals to adverse metabolic profiles in later life. OBJECTIVE: We examined the association of maternal urinary OP pesticide metabolite concentrations in pregnancy with offspring body mass index (BMI) and fat measures at 10...article 2023
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Brink, S.M. (author), Wortelboer, H. (author), Emmelot, C.H. (author), Visscher, T.L.S. (author), van Wietmarschen, H.A. (author)Current obesity management strategies are failing to achieve sustainable and favorable long-term results. We propose a more personalized, dynamic, and systemic perspective on the interactions of key determinants and coaching advice on obesity. The aim of this study was to use a systems view on overweight, complexity science, and a...article 2022
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Huizing, A. (author), Welten, M. (author), Schönbeck, Y. (author), van Empelen, P. (author), Wahab, R. (author), Jaddoe, V. (author), van Buuren, S. (author)Aims –Identification of children with an increased risk of future overweight or obesity enables targeted preventive strategies. The objective of this study is to develop a screening algorithm that can detect young children with a high risk on overweight or obesity at early adolescence (age 10 – 14 years). Materials and methods – We analyzed a...conference paper 2022
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Seidel, F. (author), Kleemann, R. (author), van Duyvenvoorde, W. (author), van Trigt, N. (author), Keijzer, N. (author), van der Kooij, S. (author), van Kooten, C. (author), Verschuren, L. (author), Menke, A. (author), Kiliaan, A.J. (author), Winter, J. (author), Hughes, T.R. (author), Morgan, P. (author), Baas, F. (author), Fluiter, K. (author), Morrison, M.C. (author)Background: Chronic inflammation is an important driver in the progression of non-alcoholic steatohepatitis (NASH) and atherosclerosis. The complement system, one of the first lines of defense in innate immunity, has been implicated in both diseases. However, the potential therapeutic value of complement inhibition in the ongoing disease remains...article 2022
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Pinart, M. (author), Dötsch, A. (author), Schlicht, K. (author), Laudes, M. (author), Bouwman, J. (author), Forslund, S.F. (author), Pischon, T. (author), Nimptsch, K. (author)Whether the gut microbiome in obesity is characterized by lower diversity and altered composition at the phylum or genus level may be more accurately investigated using high-through-put sequencing technologies. We conducted a systematic review in PubMed and Embase including 32 cross-sectional studies assessing the gut microbiome composition by...article 2022
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Komninos, D. (author), Ramos, L. (author), van der Heijden, G.W. (author), Morrison, M.C. (author), Kleemann, R. (author), van Herwaarden, A.E. (author), Kiliaan, A.J. (author), Arnoldussen, I.A.C. (author)Obesity can disturb spermatogenesis and subsequently affect male fertility and reproduction. In our study, we aim to elucidate at which cellular level of adult spermatogenesis the detrimental effects of obesity manifest. We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr−/−.Leiden) mice, and studied...article 2022
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Arnoldussen, I.A.C. (author), Morrison, M.C. (author), Wiesmann, M. (author), van Diepen, J.A. (author), Worms, N. (author), Voskuilen, M. (author), Verweij, V. (author), Greenen, B. (author), Pujol Gauldo, N. (author), van der Logt, L. (author), Gross, G. (author), Verschuren, L. (author), Kleemann, R. (author), Kiliaan, A.J. (author)Background. Milk-fat globule membrane (MFGM) is a complex structure secreted by the mammary gland and present in mammalian milk. MFGM contains lipids and glycoproteins as well as gangliosides, which may be involved in myelination processes. Notably, myelination and thereby white matter integrity are often altered in obesity. Furthermore, MFGM...article 2022
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Gart, E. (author), Salic, K. (author), Morrison, M.C. (author), Giera, M. (author), Attema, J. (author), de Ruiter, C. (author), Caspers, M.P.M. (author), Schuren, F. (author), Bobeldijk-Pastorova, I. (author), Heer, M. (author), Qin, Y. (author), Kleemann, R. (author)Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder that is associated with gut dysbiosis, enhanced gut permeability, adiposity and insulin resistance. Prebiotics such as human milk oligosaccharide 2'-fucosyllactose are thought to primarily improve gut health and it is uncertain whether they would affect more distant...article 2022
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Morrison, M.C. (author), Gart, E. (author), van Duyvenvoorde, W. (author), Snabel, J. (author), Nielsen, M.J. (author), Leeming, D.J. (author), Menke, A. (author), Kleemann, R. (author)The development of non-alcoholic steatohepatitis (NASH) has been associated with alterations in gut microbiota composition and reduced gut barrier function. Akkermansia muciniphila is a gut microbe that is thought to have health-promoting properties, including the ability to improve gut barrier function and host metabolism, both when...article 2022
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van den Berge, M. (author), van der Beek, A.J. (author), Türkeli, R. (author), van Kalken, M. (author), Hulsegge, G. (author)Objective: This study investigated associations between the co-existence of multiple types of work-related psychosocial and physical risk factors, and (1) obesity; (2) smoking; and (3) leisure-time physical inactivity. It also aimed to identify sociodemographic characteristics related to clustering of work-related risk factors and lifestyle...article 2021
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van Trijp, M.P.H. (author), Schutte, S. (author), Esser, D. (author), Wopereis, S. (author), Hoevenaars, F.P.M. (author), Hooiveld, G.J.E.J. (author), Afman, L.A. (author)Background: Whole grain wheat (WGW) products are advocated as a healthy choice when compared with refined wheat (RW). One proposed mechanism for these health benefits is via the microbiota, because WGW contains multiple fibers. WGW consumption has been proposed to ameliorate nonalcoholic fatty liver disease, in which microbiota might play a role...article 2021
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Álvarez-Amor, L. (author), Sierra, A.L. (author), Cárdenas, A. (author), López-Bermudo, L. (author), López-Beas, J. (author), Andújar, E. (author), Pérez-Alegre, M. (author), Gallego-Durán, R. (author), Varela, L.M. (author), Martin-Montalvo, A. (author), Berná, G. (author), Rojas, A. (author), Robles-Frías, J. (author), Hmadcha, A. (author), Romero-Gómez, M. (author), Kleemann, R. (author), Martín, F. (author)Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition is critical for IR and subsequent NAFLD development. Extra-virgin olive oil (EVOO) is the main source of monounsaturated fatty acids (MUFA) in Mediterranean...article 2021
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Gart, E. (author), van Duyvenvoorde, W. (author), Toet, K. (author), Caspers, M.P.M. (author), Verschuren, L. (author), Nielsen, M.J. (author), Leeming, D.J. (author), Lima, E.S. (author), Menke, A. (author), Hanemaaijer, R. (author), Keijer, J. (author), Salic, K. (author), Kleemann, R. (author), Morrison, M.C. (author)In obesity-associated non-alcoholic steatohepatitis (NASH), persistent hepatocellular damage and inflammation are key drivers of fibrosis, which is the main determinant of NASH-associated mortality. The short-chain fatty acid butyrate can exert metabolic improvements and anti-inflammatory activities in NASH. However, its effects on NASH...article 2021
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Haji, M. (author), Memelink, R.G. (author), Brandt, B.W. (author), Buijs, M.J. (author), Pasman, W.J. (author), de Vogel-Bosch, J. (author), Wopereis, S. (author), Zaura, E. (author), Weijs, P.J.M. (author)Rationale: While combined lifestyle interventions have multiple health benefits, their impact on the oral microbiome is not known. We explored the effects of a lifestyle intervention including protein drink on the oral microbiome in older adults with obesity and type 2 diabetes (T2D). Methods: In a post-hoc analysis of the PROBE study, 87...article 2021
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van Bilsen, J.H.M. (author), van den Brink, W. (author), van den Hoek, A.M. (author), Dulos, R. (author), Caspers, M.P.M. (author), Kleeman, R. (author), Wopereis, S. (author), Verschuren, L. (author)Metabolic disorders, such as obesity and type 2 diabetes have a large impact on global health, especially in industrialized countries. Tissue-specific chronic low-grade inflammation is a key contributor to complications in metabolic disorders. To support therapeutic approaches to these complications, it is crucial to gain a deeper understanding...article 2021