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Shankar, K. (author), Pivik, R.T. (author), Johnson, S.L. (author), van Ommen, B. (author), Demmer, E. (author), Murray, R. (author)Understanding health requires more than knowledge of the genome. Environmental factors regulate gene function through epigenetics. Collectively, environmental exposures have been called the "exposome." Caregivers are instrumental in shaping exposures in a child's initial years. Maternal dietary patterns, physical activity, degree of weight gain,...article 2018
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van den Broek, T.J. (author), Kremer, B.H.A. (author), marcondes Rezende, M. (author), Hoevenaars, F.P.M. (author), Weber, P. (author), Hoeller, U. (author), van Ommen, B. (author), Wopereis, S. (author)Background. Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respond to a physiological challenge, is an essential indicator of health status. Therefore, health can be measured by applying a...article 2017
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Yang, C. (author), Pinart, M. (author), Kolsteren, P. (author), van Camp, J. (author), de Cock, N. (author), Nimptsch, K. (author), Pischon, T. (author), Laird, E. (author), Perozzi, G. (author), Canali, R. (author), Hoge, A. (author), Stelmach-Mardas, M. (author), Dragsted, L.O. (author), Palombi, S.M. (author), Dobre, I. (author), Bouwman, J. (author), Clarys, P. (author), Minervini, F. (author), de Angelis, M. (author), Gobbetti, M. (author), Tafforeau, J. (author), Coltell, O. (author), Corella, D. (author), de Ruyck, H. (author), Walton, J. (author), Kehoe, L. (author), Matthys, C. (author), de Baets, B. (author), de Tré, G. (author), Bronselaer, A. (author), Rivellese, A. (author), Giacco, R. (author), Lombardo, R. (author), de Clercq, S. (author), Hulstaert, N. (author), Lachat, C. (author)Pooled analysis of secondary data increases the power of research and enables scientific discovery in nutritional epidemiology. Information on study characteristics that determine data quality is needed to enable correct reuse and interpretation of data. This study aims to define essential quality characteristics for data from observational...article 2017
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van den Broek, T.J. (author), Bakker, G.C.M. (author), Rubingh, C.M. (author), Bijlsma, S. (author), Stroeve, J.H.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Wopereis, S. (author)Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of...article 2017
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Hendriksen, M.A.H. (author), Verkaik-Kloosterman, J. (author), Noort, M.W. (author), van Raaij, J.M.A. (author)Background/objectives: Sodium intake in the Netherlands is substantially above the recommended intake of 2400 mg/day. This study aimed to estimate the effect of two sodium reduction strategies, that is, modification of the composition of industrially processed foods toward the technologically feasible minimum level or alteration of consumers’...article 2015
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TNO Kwaliteit van Leven (author), Stroeve, J.H.M. (author), van Wietmarschen, H. (author), Kremer, B.H.A. (author), van Ommen, B. (author), Wopereis, S. (author)Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life challenges. Physiology acts as a well-orchestrated machinery to adapt to the continuously changing environment. We term this adaptive...article 2015
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Meunier, L. (author), Garthoff, J.A. (author), Schaafsma, A. (author), Krul, L. (author), Schrijver, J. (author), van Goudoever, J.B. (author), Speijers, G. (author), Vandenplas, Y. (author)Locust bean gum (LBG) is a galactomannan polysaccharide used as thickener in infant formulas with the therapeutic aim to treat uncomplicated gastroesophageal reflux (GER). Since its use in young infants below 12. weeks of age is not explicitly covered by the current scientific concept of the derivation of health based guidance values, the...article 2014
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TNO Kwaliteit van Leven (author), Molag, M.L. (author), de Vries, J.H.M. (author), Duif, N. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), Goldbohm, R.A. (author), van 't Veer, P. (author)The authors automated the selection of foods in a computer system that compiles and processes tailored FFQ. For the selection of food items, several methods are available. The aim of the present study was to compare food lists made by MOM2, which identifies food items with highest between-person variance in intake of the nutrients of interest...article 2010
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de Vogel, S. (author), Dindore, V. (author), van Engeland, M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)Adequate intake of folate, methionine, riboflavin, and vitamin B-6 may prevent aberrant DNA methylation and thereby protect against colorectal cancer (CRC). However, previous epidemiological studies investigating associations between dietary intakes of these nutrients and CRC have been inconsistent. We investigated the associations between...article 2008
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Hogervorst, J.G. (author), Schouten, L.J. (author), Konings, E.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Background: Acrylamide, a probable human carcinogen, was recently detected in various heat-treated carbohydrate-rich foods. Epidemiologic studies on the relation with cancer have been few and largely negative. Objective: We aimed to prospectively examine the association between dietary acrylamide intake and renal cell, bladder, and prostate...article 2008
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Heinen, M.M. (author), Verhage, B.A.J. (author), Lumey, L.H. (author), Brants, H.A.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Background: Recent studies of pancreatic cancer suggest a role for hyperinsulinemia in carcinogenesis. Because insulin is secreted in response to elevated blood glucose concentrations, dietary factors that increase these concentrations may be important in pancreatic carcinogenesis. Objective: The objective was to examine prospectively the...article 2008
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- van Buuren, S. (author), van Wouwe, J.P. (author), TNO Kwaliteit van Leven (author) article 2008
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TNO Kwaliteit van Leven (author), van Ommen, B. (author), Fairweather-Tait, S. (author), Freidig, A. (author), Kardinaal, A. (author), Scalbert, A. (author), Wopereis, S. (author)Micronutrients are involved in specific biochemical pathways and have dedicated functions in the body, but they are also interconnected in complex metabolic networks, such as oxidative-reductive and inflammatory pathways and hormonal regulation, in which the overarching function is to optimise health. Post-genomic technologies, in particular...article 2008
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TNO Kwaliteit van Leven (author), van Ommen, B. (author), Keijer, J. (author), Kleemann, R. (author), Elliott, R. (author), Drevon, C.A. (author), McArdle, H. (author), Gibney, M. (author), Müller, M. (author)In quantifying the beneficial effect of dietary interventions in healthy subjects, nutrition research meets a number of new challenges. Inter individual variation in biomarker values often is larger than the effect related to the intervention. Healthy subjects have a remarkable capacity to maintain homeostasis, both through direct metabolic...article 2008
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- Dousma, M. (author), Wierdsma, N. (author), van Ede, J. (author), van Buuren, S. (author), Heijmans, H.S.A. (author), de Vries, T.W. (author), TNO Kwaliteit van Leven (author) article 2007
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Molag, M.L. (author), de Vries, J.H.M. (author), Ocké, M.C. (author), Dagnelie, P.C. (author), van den Brandt, P.A. (author), Jansen, M.C.J.F. (author), van Staveren, W.A. (author), van 't Veer, P. (author), TNO Kwaliteit van Leven (author)The authors investigated the role of food frequency questionnaire (FFQ) design, including length, use of portion-size questions, and FFQ origin, in ranking subjects according to their nutrient intake. They also studied the ability of the FFQ to detect differences in energy intake between subgroups and to assess energy and protein intake. In a...article 2007
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Slimani, N. (author), Deharveng, G. (author), Unwin, I. (author), Southgate, D.A.T. (author), Vignat, J. (author), Skeie, G. (author), Salvini, S. (author), Parpinel, M. (author), Møller, A. (author), Ireland, J. (author), Becker, W. (author), Farran, A. (author), Westenbrink, S. (author), Vasilopoulou, E. (author), Unwin, J. (author), Borgejordet, Å. (author), Rohrmann, S. (author), Church, S. (author), Gnagnarella, P. (author), Casagrande, C. (author), van Bakel, M. (author), Niravong, M. (author), Boutron-Ruault, M.C. (author), Stripp, C. (author), Tjønneland, A. (author), Trichopoulou, A. (author), Georga, K. (author), Nilsson, S. (author), Mattisson, I. (author), Ray, J. (author), Boeing, H. (author), Ocké, M. (author), Peeters, P.H.M. (author), Jakszyn, P. (author), Amiano, P. (author), Engeset, D. (author), Lund, E. (author), Santucci de Magistris, M. (author), Sacerdote, C. (author), Welch, A. (author), Bingham, S. (author), Subar, A.F. (author), Riboli, E. (author), TNO Kwaliteit van Leven (author)Objective: This paper describes the ad hoc methodological concepts and procedures developed to improve the comparability of Nutrient databases (NDBs) across the 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). This was required because there is currently no European reference NDB...article 2007
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TNO Kwaliteit van Leven (author), Joost, H.G. (author), Gibney, M.J. (author), Cashman, K.D. (author), Görman, U. (author), Hesketh, J.E. (author), Mueller, M. (author), van Ommen, B. (author), Williams, C.M. (author), Mathers, J.C. (author)Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine...article 2007
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TNO Kwaliteit van Leven (author), Bongaerts, B.W.C. (author), de Goeij, A.F.P.M. (author), de Vogel, S. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Weijenberg, M.P. (author)High alcohol consumption is related to colorectal cancer (CRC). Our objective was to study associations between alcohol consumption and risk of CRC according to characteristics of aetiological pathways: the chromosomal instability (CIN) and the microsatellite instability (MIN) pathway. We classified CIN+ tumours (tumours with either a truncating...article 2007
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TNO Kwaliteit van Leven (author), Rist, L. (author), Mueller, A. (author), Barthel, C. (author), Snijders, B. (author), Jansen, M. (author), Simões-Wüst, A.P. (author), Huber, M. (author), Kummeling, I. (author), von Mandach, U. (author), Steinhart, H. (author), Thijs, C. (author)The aim of the present study was to find out whether the incorporation of organic dairy and meat products in the maternal diet affects the contents of the conjugated linoleic acid isomers (CLA) and trans-vaccenic acid (TVA) in human breast milk. To this purpose, milk samples from 312 breastfeeding mothers participating in the KOALA Birth Cohort...article 2007
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