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Wickramasinghe, K. (author), Mathers, J.C. (author), Wopereis, S. (author), Marsman, D.S. (author), Griffiths, J.C. (author)Across the globe, there has been a marked increase in longevity, but significant inequalities remain. These are exacerbated by inadequate access to proper nutrition and health care services and to reliable information to make the decisions related to nutrition and health care. Many in economically developing as well as developed societies are...article 2020
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Kiesswetter, E. (author), Hengeveld, L.M. (author), Keijser, B.J. (author), Volkert, D. (author), Visser, M. (author)Objective: Poor oral health might be a modifiable determinant of malnutrition in older age. We aimed to investigate the associations of multiple oral health characteristics with incident malnutrition in community-dwelling older adults. Methods: This exploratory analysis is based on prospective data from 893 participants, aged 55–80 years without...article 2019
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Fallaize, R. (author), Livingstone, K.M. (author), Celis-Morales, C. (author), Macready, A.L. (author), San-Cristobal, R. (author), Navas-Carretero, S. (author), Marsaux, C.F.M. (author), O’Donovan, C.B. (author), Kolossa, S. (author), Moschonis, G. (author), Walsh, M.C. (author), Gibney, E.R. (author), Brennan, L. (author), Bouwman, J. (author), Manios, Y. (author), Jarosz, M. (author), Martinez, J.A. (author), Daniel, H. (author), Saris, W.H.M. (author), Gundersen, T.E. (author), Drevon, C.A. (author), Gibney, M.J. (author), Mathers, J.C. (author), Lovegrove, J.A. (author)Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore,...article 2018
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van den Broek, T.J. (author), Kremer, B.H.A. (author), marcondes Rezende, M. (author), Hoevenaars, F.P.M. (author), Weber, P. (author), Hoeller, U. (author), van Ommen, B. (author), Wopereis, S. (author)Background. Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respond to a physiological challenge, is an essential indicator of health status. Therefore, health can be measured by applying a...article 2017
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Hendriksen, M.A.H. (author), Verkaik-Kloosterman, J. (author), Noort, M.W. (author), van Raaij, J.M.A. (author)Background/objectives: Sodium intake in the Netherlands is substantially above the recommended intake of 2400 mg/day. This study aimed to estimate the effect of two sodium reduction strategies, that is, modification of the composition of industrially processed foods toward the technologically feasible minimum level or alteration of consumers’...article 2015
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Raiten, D.J. (author), Sakr Ashour, F.A. (author), Ross, A.C. (author), Meydani, S.N. (author), Dawson, H.D. (author), Stephensen, C.B. (author), Brabin, B.J. (author), Suchdev, P.S. (author), van Ommen, B. (author), Ahluwalia, N. (author), Ahmed, T. (author), Allen, L. (author), Beck, M. (author), Blanchard, H. (author), Brindle, E. (author), Brown, K. (author), Calder, P. (author), Checkley, W. (author), Claycombe, K. (author), Coles, C. (author), Esamai, F. (author), Friis, H. (author), Gardner, E. (author), Grinspoon, S. (author), Guerrant, R. (author), Hellerstein, M. (author), Hunt, J. (author), King, J. (author), Klasing, K. (author), Kramer, B. (author), Koski, K. (author), Northrop-Clewes, C. (author), Pfeiffer, C. (author), Prentice, A. (author), Ramirez-Zea, M. (author), van Rheenan, P. (author), Rink, L. (author), Srinivasa, S. (author), Benn, C.S. (author), Stephensen, C. (author), Suchdev, P. (author), Sullivan, K. (author), Thurnham, D. (author), Varadhan, R. (author), Van Der Ven, A. (author), Walston, J. (author), Xia, J. (author)An increasing recognition has emerged of the complexities of the global health agenda-specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and...article 2015
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Smits, K.M. (author), Schouten, L.J. (author), Hudak, E. (author), Verhage, B. (author), van Dijk, B.A.C. (author), van de Hulsbergen - Kaa, C.A. (author), Goldbohm, R.A. (author), Oosterwijk, E. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Purpose: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which...article 2010
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Ashwell, M. (author), Lambert, J.P. (author), Alles, M.S. (author), Branca, F. (author), Bucchini, L. (author), Brzozowska, A. (author), de Groot, L.C.P.G.M. (author), Dhonukshe-Rutten, R.A.M. (author), Dwyer, J.T. (author), Fairweather-Tait, S. (author), Koletzko, B. (author), Pavlovic, M. (author), Raats, M.M. (author), Serra-Majem, L. (author), Smith, R. (author), van Ommen, B. (author), Veer, P.V. (author), Von Rosen, J. (author), Pijls, L.T.J. (author), TNO Kwaliteit van Leven (author)Background: There is considerable variation in the recommended micronutrient intakes used by countries within Europe, partly due to different methodologies and concepts used to determine requirements and different approaches used to express the recommendations. As populations become more mobile and multi-national, and more traditional foods...article 2008
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TNO Kwaliteit van Leven (author), van Ommen, B. (author), Fairweather-Tait, S. (author), Freidig, A. (author), Kardinaal, A. (author), Scalbert, A. (author), Wopereis, S. (author)Micronutrients are involved in specific biochemical pathways and have dedicated functions in the body, but they are also interconnected in complex metabolic networks, such as oxidative-reductive and inflammatory pathways and hormonal regulation, in which the overarching function is to optimise health. Post-genomic technologies, in particular...article 2008
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van Uffelen, J.G.Z. (author), Chin A Paw, M.J.M. (author), Hopman-Rock, M. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)Objectives: To examine the effect of walking and vitamin B supplementation on quality-of-life (QoL) in community-dwelling adults with mild cognitive impairment. Methods: One year, double-blind, placebo-controlled trial. Participants were randomized to: (1) twice-weekly, group-based, moderate-intensity walking program (n = 77) or a light...article 2007
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Beulens, J.W.J. (author), Rimm, E.B. (author), Ascherio, A. (author), Spiegelman, D. (author), Hendriks, H.F.J. (author), Mukamal, K.J. (author), TNO Kwaliteit van Leven (author)Background: Heavy alcohol consumption increases risk for hypertension, which is in itself a strong risk factor for cardiovascular disease (CVD). However, data on the association between alcohol consumption and CVD among individuals with hypertension are scarce. Objective: To assess whether alcohol consumption is inversely associated with CVD...article 2007
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TNO Kwaliteit van Leven (author), Joost, H.G. (author), Gibney, M.J. (author), Cashman, K.D. (author), Görman, U. (author), Hesketh, J.E. (author), Mueller, M. (author), van Ommen, B. (author), Williams, C.M. (author), Mathers, J.C. (author)Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine...article 2007
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van der Greef, J. (author), Hankemeier, T. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)Personalized medicine - defined as customized medical care for each patient's unique condition - in the broader context of personalized health, will make significant strides forward when a systems approach is implemented to achieve the ultimate in disease phenotyping and to create novel therapeutics that address system-wide molecular...article 2006
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Finglas, P.M. (author), de Meer, K. (author), Molloy, A. (author), Verhoef, P. (author), Pietrzik, K. (author), Powers, H.J. (author), van der Straeten, D. (author), Jägerstad, M. (author), Varela-Moreiras, G. (author), van Vliet, T. (author), Havenaar, R. (author), Buttriss, J. (author), Wright, A.J.A. (author), TNO Kwaliteit van Leven (author)In the past decade, the understanding of folate bioavailability, metabolism and related health issues has increased, but several problems remain, including the difficulty of delivering the available knowledge to the populations at risk. Owing to the low compliance of taking folic acid supplements, for example, among women of child-bearing age...article 2006
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Verwei, M. (author), Freidig, A.P. (author), Havenaar, R. (author), Groten, J.P. (author), TNO Kwaliteit van Leven (author)The nutritional quality of new functional or fortified food products depends on the bioavailability of the nutrient(s) in the human body. Bioavailability is often determined in human intervention studies by measurements of plasma or serum profiles over a certain time period. These studies are time and cost consuming and often appear to lack an...article 2006
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Schaafsma, G. (author), TNO Kwaliteit van Leven (author)Loss of muscle mass as a consequence of changes in protein metabolism during periods of catabolic stress is a serious complication in a variety of conditions. These conditions are weight loss programs, sarcopenia in the elderly and several clinical states. It appears from many studies that improved protein nutrition by ingestion of high-quality...article 2006
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Dhonukshe-Rutten, R.A.M. (author), van Dusseldorp, M. (author), Schneede, J. (author), de Groot, L.C.P.G.M. (author), van Staveren, W.A. (author), TNO Kwaliteit van Leven (author)Background: Cobalamin deficiency is prevalent in vegetarians and has been associated with increased risk of osteoporosis. Aim of the study: To examine the association between cobalamin status and bone mineral density in adolescents formerly fed a macrobiotic diet and in their counterparts. Methods: In this cross-sectional study bone mineral...article 2005
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Dagnelie, P.C. (author), Schuurman, A.G. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding (author)We reviewed 37 prospective cohort and four intervention studies on potential dietary risk factors for prostate cancer, published between 1966 and September 2003. Some studies were limited by small size, crude measurement of dietary exposure and limited control for confounders. Intervention and prospective cohort studies support a protective role...article 2004
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Fox, T.E. (author), van den Heuvel, E.G.H.M. (author), Atherton, C.A. (author), Dainty, J.R. (author), Lewis, D.J. (author), Langford, N.J. (author), Crews, H.M. (author), Luten, J.B. (author), Lorentzen, M. (author), Sieling, F.W. (author), van Aken-Schneyder, P. (author), Hoek, M. (author), Kotterman, M.J.J. (author), van Dael, P. (author), Firweather-Tail, S.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To measure the bioavailability of selenium from cooked and raw fish in humans by estimating and comparing apparent absorption and retention of selenium in biosynthetically labelled fish with labelled selenate and biosynthetically labelled selenium in brewers yeast. Design: The intervention study was a parallel, randomised, reference...article 2004
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Jansen, M.C.J.F. (author), van Kappel, A.L. (author), Ocké, M.C. (author), van 't Veer, P. (author), Boshuizen, H.C. (author), Riboli, E. (author), Bueno-de-Mesquita, H.B. (author), TNO Voeding (author)Objective: Fruit and vegetable intake is inversely associated with cancer risk in many epidemiological studies. Accurate assessment of consumption of these foods is difficult, and biomarkers of intake would overcome several drawbacks of currently used dietary assessment methods. Therefore, we investigated the relation between plasma carotenoids...article 2004