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A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity

Desprez, B. (author), Birk, B. (author), Blaauboer, B. (author), Boobis, A. (author), Carmichael, P. (author), Cronin, M.T.D. (author), Curie, R. (author), Daston, G. (author), Hubesch, B. (author), Jennings, P. (author), Klaric, M. (author), Kroese, D. (author), Mahony, C. (author), Ouédraogo, G. (author), Piersma, A. (author), Richarz, A.N. (author), Schwarz, M. (author), van Benthem, J. (author), van de Water, B. (author), Vinken, M. (author)

Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this...

article 2019

document

Case-specific colleague guidance for general practitioners' management of sickness absence

Nordhagen, H.P. (author), Harvey, S.B. (author), Rosvold, E.O. (author), Bruusgaard, D. (author), Blonk, R. (author), Mykletun, A. (author)

Background General practitioners (GPs) report sickness absence certification as challenging. They express need for support with functional assessment beyond guidelines and reforms. Case-specific collegial oneto- one guidance for other clinical topics has proved popular with GPs and may be an acceptable and effective way to improve GPs skills and...

article 2017

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Allergenicity assessment strategy for novel food proteins and protein sources

Verhoeckx, K. (author), Broekman, H. (author), Knulst, A. (author), Houben, G. (author)

To solve the future food insecurity problem, alternative and sustainable protein sources (e.g. insects, rapeseed, fava bean and algae) are now being explored for the production of food and feed. To approve these novel protein sources for future food a comprehensive risk assessment is needed according to the European food legislation....

article 2016

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Locally sourced probiotics, the next opportunity for developing countries?

Sybesma, W. (author), Kort, R. (author), Lee, Y.K. (author)

We describe factors promoting the exploration of locally sourced probiotics, targeting local populations to balance human needs and market opportunities. This would be particularly beneficial for people in developing countries, who generally lack access to affordable probiotics and are often exposed to poor hygiene conditions, toxic compounds,...

article 2015

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Gastro-oesofageale reflux bij zuigelingen: Een grotere rol voor de jeugdarts [Gastro-oesophageal reflux in infants: A more prominent role for the youth healthcare physician]

de Jong, T. (author), Kamphuis, M. (author), Kivit-Schwengle, L. (author)

article 2014

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Results from an online computer-tailored weight management intervention for overweight adults: Randomized controlled trial

van Genugten, G.L. (author), van Empelen, E.P. (author), Boon, B. (author), Borsboom, G. (author), Visscher, T. (author), Oenema, A. (author)

article 2013

document

Technical note: Spine loading in automotive seating

Zenk, R. (author), Franz, M. (author), Bubb, H. (author), Vink, P. (author)

For car manufacturers, seat comfort is becoming more important in distinguishing themselves from their competitors. Therefore, many studies on participative seat comfort are carried out. In this paper, an objective assessment approach is reported which evaluates the concept of "optimal load distribution", based on the identification of a close...

article 2012

document

Sikkelcelziekte in de hielprikscreening I [Sickle cell disease in newborn screening: I. Children detected in the first year I}

Peters, M. (author), Appel, I.M. (author), Cnossen, M.H. (author), Breuning-Boers, J.M. (author), Heijboer, H. (author)

Doel Evalueren van de uitkomsten van het eerste jaar na invoering van de uitbreiding van de landelijke hielprikscreening met sikkelcelziekte (SCZ). Opzet Prospectieve landelijke registratie van kinderen met vermoedelijk SCZ of een andere vorm van ernstige hemoglobinopathie. Methode De bloedspots werden geanalyseerd met een...

article 2009

document

Should we screen for language delay in toddlers?

van der Ploeg, C.P.B. (author), Lanting, C.I. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)

article 2008

document

Prevention of work-related airway allergies; summary of the advice from the Health Council of the Netherlands

Rijnkels, J.M. (author), Smid, T. (author), van den Aker, E.C. (author), Burdorf, A. (author), van Wijk, R.G. (author), Heederik, D.J.J. (author), Houben, G.F. (author), van Loveren, H. (author), Pal, T.M. (author), van Rooy, F.G.B.G.J. (author), van der Zee, J.S. (author)

The Health Council of the Netherlands published a report in which the best procedure and method for recommending health-based occupational exposure limits (OELs) for inhaled allergens were identified by evaluating the scientific state of the art. Many respiratory disorders in the workplace arise from inhalation of substances which can cause...

article 2008

document

WHO child growth standards in action

van Buuren, S. (author), van Wouwe, J.P. (author), TNO Kwaliteit van Leven (author)

article 2008

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Prevention of sudden unexpected infant death

van Wouwe, J.P. (author), Hirasing, R.A. (author)

article 2006

document

Alcohol and ischaemic heart disease [7]

Beulens, J.W.J. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)

article 2006

document

Discovery of thrombin activatable fibrinolysis inhibitor (TAFI)

Bertina, R.M. (author), van Tilburg, N.H. (author), Haverkate, F. (author), Bouma, B.N. (author), von dem Borne, P.A.K. (author), Meijers, J.C.M. (author), Campbell, W. (author), Eaton, D. (author), Hendriks, D.F. (author), Willemse, J.L. (author), TNO Kwaliteit van Leven (author)

CAS: blood clotting factor 11, 9013-55-2; thrombin, 9002-04-4; tissue plasminogen activator, 105913-11-9; protein C, 60202-16-6; Carboxypeptidase U, 3.4.17.20; Protein C; Tissue Plasminogen Activator, 3.4.21.68

article 2006

document

Apolipoprotein AV: Low concentration, high impact

Rensen, P.C.N. (author), van Dijk, K.W. (author), Havekes, L.M. (author), TNO Kwaliteit van Leven (author)

Chemicals / CAS: lipoprotein lipase, 83137-80-8, 9004-02-8; APOA5 protein, human; Apolipoproteins A; Apolipoproteins; Triglycerides

article 2005

document

The effect of school screening on surgery for adolescent idiopathic scoliosis: Reanalysis is needed

Reijneveld, S.A. (author), Hirasing, R.A. (author)

article 2000

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Opsporing familiaire hypercholesterolemie bij kinderen geindiceerd? Bij uitzondering wel [Search for familial hypercholesterolaemia in children indicated? Only exceptionally]

Gevers Leuven, J.A. (author), TNO Preventie en Gezondheid (author)

Searching for familial hypercholesterolaemia (FH) in children is useful only if efficacious treatment is to be administered shortly and if there are relatives with ischaemic heart disease at very early ages. In all other cases, the (psychological) drawbacks probably outweigh the doubtful benefit of early intervention. The search for the major...

article 1997

document

On the in vivo and in vitro interaction of tissue-type plasminogen activator with liver cells

Otter, M. (author), Gaubius Laboratory, IVVO-TNO, Zernikedreef 9, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)

Dissertation abstract

article 1993

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Variant-specific monoclonal and group-specific polyclonal human immunodeficiency virus type 1 neutralizing antibodies raised with synthetic peptides from the gp120 third variable domain

Medisch Biologisch Laboratorium TNO (author), Laman, J.D. (author), Schellekens, M.M. (author), Abacioglu, Y.H. (author), Lewis, G.K. (author), Tersmette, M. (author), Fouchier, R.A.M. (author), Langedijk, J.P.M. (author), Claassen, E. (author), Boersma, W.J.A. (author)

The third variable (V3) domain of the human immunodeficiency virus type 1 (HIV-1) external membrane glycoprotein gp120 is of crucial importance in eliciting neutralizing antibodies in infected persons. Polyclonal (PAb) and monoclonal (MAb) antibodies directed against selected epitopes in the V3 domain are valuable tools for analysis of the...

article 1992