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Larsson, P.T. (author), Wallén, N.H. (author), Wiman, B. (author), Dooijewaard, G. (author), Gaubius instituut TNO (author)Objective: To study the influence of α- and β-adrenoceptor stimulation in vivo on fibrinolysis in healthy male volunteers. Design: Infusions were given in a single blind fashion and in a randomized order if placebo infusions were included. Setting: University Department (Karolinska Hospital). Subjects: Thirty-four healthy, non-smoking male...article 1999
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Sloot, W.N. (author), van der Sluijs-Gelling, A.J. (author), Gramsbergen, J.B.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Regional 45Ca2+ accumulation and analysis of monoamines and metabolites in dissected tissues were used to localize, quantify, and characterize brain damage after intracerebral injections of Mn2+ into striatum and hippocampus. The specificity of Mn2+-induced lesions is described in relation to brain damage produced by local Fe2+ or 6-...article 1994
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de Lange, J. (author), van Eck, P. (author), Elliott, G.R. (author), de Kort, W.L.A.M. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)To overcome most of the disadvantages of current models to investigate percutaneous penetration of drugs or toxic substances, a model is proposed here based on the isolated pig ear, which is obtained at the slaughterhouse, and perfused with oxygenated blood from the same pig. To determine the viability of the preparations, we measured glucose...article 1992
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CIVO Centraal instituut voor voedingsonderzoek TNO Werkgroep biomedische instrumentatie TNO (author), Langewouters, G.J. (author), Zwart, A. (author), Busse, R. (author), Wesseling, K.H. (author)Pressure-diameter relationships of segments of human finger arteries, aged 57-85 years, were measured in vitro. The arteries, obtained at autopsy within 48 h after death, were stored in glucose-free Tyrode at 4 degrees C. Experiments began within 40 h after autopsy. The diameter responses to various transmural pressure changes, with and without...article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), Odink, J. (author), van der Beek, E.J. (author), van den Berg, H. (author), Bogaards, J.J.P. (author), Thissen, J.T.N.M. (author)The effects of maximal performance capacity and different work load intensities on the response of free and sulfate-conjugated plasma catecholamines, prolactin (PRL), and cortisol were studied in six healthy male volunteers. In a first experiment, the volunteers had to perform a step-wise incremental bicycle ergometer test to determine the onset...article 1986
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Tas, A.C. (author), Odink, J. (author), Ten Noever De Brauw, M.C. (author), Schrijver, J. (author), Jonk, R.J.G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A method has been developed for the derivatization of both catecholamines (dopamine, noradrenaline and adrenaline) and their 3-O-methylated metabolites (3-methoxytyramine, normetanephrine and metanephrine) in a single run. The compounds were first incubated with methanolic hydrochloric acid to methylate those compounds that contain a benzylic...article 1984
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Speek, A.J. (author), Odink, J. (author), Schrijver, J. (author), Schreurs, W.H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A reliable high-performance liquid chromatographic method is presented for the determination of the urinary free catecholamines noradrenaline, adrenaline and dopamine. Urine is purified on a column of immobilized boric acid. Catecholamines are separated by ion-pair reversed phase high-performance liquid chromatography and detected...article 1983