Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats

To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway rats. Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m(3)...

Chemically modified tetracyclines stimulate matrix metalloproteinase-s production by periodontal ligament cells

Background and Objective: The purpose of this study was to investigate the effects of chemically modified tetracyclines (CMTs) on the production of gelatinases [matrix metalloproteinase (MMP)-2 and -9] by human periodontal ligament (PDL) cells, and on the activity of recombinant gelatinases. Material and Methods: Human PDL cells were cultured...

Effects of Perinatal Exposure to PCBs on Neuropsychological Functions in the Rotterdam Cohort at 9 Years of Age

PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old children of the Rotterdam PCB-dioxin cohort,...

Functional adaptation of equine articular cartilage: The formation of regional biochemical characteristics up to age one year

Biochemical heterogeneity of cartilage within a joint is well known in mature individuals. It has recently been reported that heterogeneity for proteoglycan content and chondrocyte metabolism in sheep develops postnatally under the influence of loading. No data exist on the collagen network in general or on the specific situation in the horse....

Maintenance operations - Workstation adjustment, working posture, and workers' perceptions

In the study maintenance workers were involved in pneumatic wrenching, oxy-gas cutting, and grinding at 5 different heights. Working posture and workers' perceptions were measured. Guidelines on working height were formulated in order to minimize the load on the musculoskeletal system. Data trom the present experiment as weIl as from literature...