Searched for: subject%3A%22No%255C%2BAdverse%255C%2BEffect%255C%2BLevel%22
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Westerhout, J. (author), Baumert, J.L. (author), Blom, W.M. (author), Allen, K.J. (author), Ballmer-Weber, B. (author), Crevel, R.W.R. (author), Dubois, A.E.J. (author), Fernández-Rivas, M. (author), Greenhawt, M.J. (author), Hourihane, J.O. (author), Koplin, J.J. (author), Kruizinga, A.G. (author), Le, T.M. (author), Sampson, H.A. (author), Shreffler, W.G. (author), Turner, P.J. (author), Taylor, S.L. (author), Houben, G.F. (author), Remington, B.C. (author)
Background: Food allergies are a significant public health issue, and the only effective management option currently available is strict avoidance of all foods containing the allergen. In view of the practical impossibility of limiting risks to zero, quantitative allergen risk assessment and management strategies are needed. Objective: We sought...
article 2019
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Braakhuis, H.M. (author), Slob, W. (author), Olthof, E.D. (author), Wolterink, G. (author), Zwart, E.P. (author), Gremmer, E.R. (author), Rorije, E. (author), van Benthem, J. (author), Woutersen, R. (author), van der Laan, J.W. (author), Luijten, M. (author)
Non-genotoxic carcinogens (NGTXCs) do not cause direct DNA damage but induce cancer via other mechanisms. In risk assessment of chemicals and pharmaceuticals, carcinogenic risks are determined using carcinogenicity studies in rodents. With the aim to reduce animal testing, REACH legislation states that carcinogenicity studies are only allowed...
article 2018
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Koivisto, A.J. (author), Kling, K.I. (author), Fonseca, A.S. (author), Brostrøm Bluhme, A. (author), Moreman, M. (author), Yu, M. (author), Costa, A.L. (author), Giovanni, B. (author), Ortelli, S. (author), Fransman, W. (author), Vogel, U. (author), Jensen, K.A. (author)
Nanoscale TiO2 (nTiO2) is manufactured in high volumes and is of potential concern in occupational health. Here, we measured workers exposure levels while ceramic honeycombs were dip coated with liquid photoactive nanoparticle suspension and dried with an air blade. The measured nTiO2 concentration levels were used to assess process specific...
article 2018
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Masthoff, L.J.N. (author), Blom, W.M. (author), Rubingh, C.M. (author), Klemans, R.J.B. (author), Remington, B.C. (author), Bruijnzeel-Koomen, C.A.F.M. (author), van Hoffen, E. (author), Houben, G.F. (author), Meyer, Y. (author), Pasmans, S.G.M.A. (author), Knulst, A.C. (author)
[No abstract available] Chemicals / CAS immunoglobulin E, 37341-29-0; Allergens; Antigens, Plant; Cor a 14 allergen, hazelnut; Cor a 9 protein, hazelnut; Immunoglobulin E; Plant Proteins.
article 2018
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Ponstein-Simarro Doorten, A.Y. (author), van de Wiel, J.A.G. (author), Jonker, D. (author), TNO Kwaliteit van Leven (author)
Tensguard™ is a milk protein hydrolysate containing the lactotripeptide IPP. It is derived from cow's milk, which is present in the human diet and has a safe history of consumption. The final Tensguard™ product, a supplement or a functional food ingredient, is intended for use by people who want to follow a healthy diet and lifestyle in order to...
article 2009
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Arts, J.H.E. (author), Muijser, H. (author), Kuper, C.F. (author), Woutersen, R.A. (author), TNO Kwaliteit van Leven (author)
The paper aims to evaluate the indoor air limit of 1 μg/m3 (0.8 ppb) formaldehyde as advised by the European Commission [the INDEX project; Kotzias, D., Koistinen, K., Kephalopoulos, S., Schlitt, C., Carrer, P., Maroni, M., Jantunen, M., Cochet, C., Kirchner, S., Lindvall, T., McLaughlin, J., Mølhave, L., de Oliveira Fernandes, E., Seifert, B.,...
article 2008
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Kroes, R. (author), Renwick, A.G. (author), Feron, V. (author), Galli, C.L. (author), Gibney, M. (author), Greim, H. (author), Guy, R.H. (author), Lhuguenot, J.C. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
The threshold of toxicological concern (TTC) has been used for the safety assessment of packaging migrants and flavouring agents that occur in food. The approach compares the estimated oral intake with a TTC value derived from chronic oral toxicity data for structurally-related compounds. Application of the TTC approach to cosmetic ingredients...
article 2007
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Peeters, K.A.B.M. (author), Koppelman, S.J. (author), van Hoffen, E. (author), van der Tas, C.W.H. (author), den Hartog Jager, C.F. (author), Penninks, A.H. (author), Hefle, S.L. (author), Bruijnzeel-Koomen, C.A.F.M. (author), Knol, E.F. (author), Knulst, A.C. (author), TNO Kwaliteit van Leven (author)
Background: Recognition of specific peanut allergens or the diversity of IgE binding to peanut allergens may play a role in the elicitation of severe allergic reactions. Objective: To investigate whether sensitization to individual allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 is correlated with clinical severity. Methods: The reactivity of...
article 2007
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Adams, T.B. (author), McGowen, M.M. (author), Williams, M.C. (author), Cohen, S.M. (author), Feron, V.J. (author), Goodman, J.I. (author), Marnett, L.J. (author), Munro, I.C. (author), Portoghese, P.S. (author), Smith, R.L. (author), Waddell, W.J. (author), TNO Kwaliteit van Leven (author)
This publication is the 11th in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. The list of GRAS substances has now...
article 2007
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Hendriksen, P.J.M. (author), Freidig, A.P. (author), Jonker, D. (author), Thissen, U. (author), Bogaards, J.J.P. (author), Mumtaz, M.M. (author), Groten, J.P. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)
The present research aimed to study the interaction of three chemicals, methyl mercury, benzene and trichloroethylene, on mRNA expression alterations in rat liver and kidney measured by microarray analysis. These compounds were selected based on presumed different modes of action. The chemicals were administered daily for 14 days at the Lowest...
article 2007
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Appel, M.J. (author), van Veen, H.A. (author), Vietsch, H. (author), Salaheddine, M. (author), Nuijens, J.H. (author), Ziere, B. (author), de Loos, F. (author), TNO Kwaliteit van Leven (author)
The oral toxicity of recombinant human lactoferrin (rhLF) produced in the milk of transgenic cows was investigated in Wistar rats by daily administration via oral gavage for 13 consecutive weeks, 7 days per week. The study used four groups of 20 rats/sex/dose. The control group received physiological saline and the three test groups received...
article 2006
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Arts, J.H.E. (author), Mommers, C. (author), de Heer, C. (author), TNO Kwaliteit van Leven (author)
A literature study was performed to evaluate dose-response relationships and no-effect levels for sensitization and elicitation in skin- and respiratory allergy. With respect to the skin, dose-response relationships and no-effect levels were found for both intradermal and topical induction, as well as for intradermal and topical elicitation of...
article 2006
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Arts, J.H.E. (author), Rennen, M.A.J. (author), de Heer, C. (author), TNO Kwaliteit van Leven (author)
Objectives: The critical health effects of formaldehyde exposure include sensory irritation and the potential to induce tumours in the upper respiratory tract. In literature, a concentration as low as 0.24 ppm has been reported to be irritating to the respiratory tract in humans. Nasal tumour-inducing levels in experimental animals seem to be 1...
article 2006
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Lina, B. (author), Korte, H. (author), Nyman, L. (author), Unkila, M. (author), TNO Kwaliteit van Leven (author)
Plant lignan 7-hydroxymatairesinol (7-HMR) is a novel precursor of the mammalian lignan enterolactone. A 13 week toxicity study at dietary levels of 0, 0.25, 1, and 4% (w/w) of potassium acetate complex of 7-HMR (HMRlignan) was conducted in the Wistar rat. These dietary levels resulted in an average daily intake of 160, 640, and 2600 mg...
article 2005
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Wolterbeek, A.P.M. (author), Roberts, A. (author), Korte, H. (author), Unkila, M. (author), Waalkens-Berendsen, D.H. (author), TNO Voeding (author)
Plant lignan 7-hydromatairesinol, a novel precursor of the mammalian lignan enterolactone was evaluated in a prenatal developmental toxicity study conducted in the Wistar rat. Mated female rats were fed diets containing 0, 0.25, 1, and 4% (w/w) of 7-hydroxymatairesinol in the form of potassium acetate complex (HMRlignan; potassium acetate level...
article 2004
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Lina, B.A.R. (author), Bär, A. (author), TNO Voeding (author)
The oral toxicity of α-cyclodextrin (α-CD) was examined in a 13-week feeding study in which groups of Beagle dogs received α-CD in the diet at concentrations of 0 (control), 5, 10, or 20% (4dogs/sex/group). No treatment-related changes were noted in behavior or appearance of the dogs and no mortalities occurred. Diarrhea occurred in all α-CD...
article 2004
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Arts, J.H.E. (author), Muijser, H. (author), Appel, M.J. (author), Kuper, C.F. (author), Bessems, J.G.M. (author), Woutersen, R.A. (author), TNO Voeding (author)
The subacute oral and inhalation toxicity of furfural vapour was studied in Fischer 344 rats to investigate whether route-to-route extrapolation could be employed to derive the limit value for inhalation exposure from oral toxicity data. Groups of 5 rats per sex were treated by gavage daily for 28 days at dose levels of 6-192 mg/kg bw/day, or...
article 2004
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van Helden, H.H.P.M. (author), Vanwersch, R.A.P. (author), Kuijpers, W.C. (author), Trap, H.C. (author), Philippens, I.H.C. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO (author)
The main purpose of this pilot study was to estimate the lowest observable adverse effect level (LOAEL) for the electroencephalogram (EEG) upon long-term, low-level exposure of vehicle-pretreated and pyridostigmine-pretreated marmoset monkeys to sarin vapour. This is the C·t value (t = 5 h) of exposure at which the EEG becomes significantly...
article 2004
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Arts, J.H.E. (author), de Koning, M.W. (author), Bloksma, N. (author), Kuper, C.F. (author), TNO Voeding (author)
The present study investigated whether airway responses of sensitized rats to trimellitic anhydride (TMA) were concentration dependent and whether these were related to irritation by TMA. Groups of BN and Wistar rats were sensitized by two dermal applications of TMA (50% w/v, followed by 25% w/v in vehicle). Controls received vehicle (acetone...
article 2004
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Rennen, M.A.J. (author), Bouwman, T. (author), Wilschut, A. (author), Bessems, J.G.M. (author), de Heer, C. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Due to a lack of route-specific toxicity data, the health risks resulting from occupational exposure are frequently assessed by route-to-route (RtR) extrapolation based on oral toxicity data. Insight into the conditions for and the uncertainties connected with the application of RtR extrapolation has not been clearly described in a systematic...
article 2004
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