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Mihaescu, R. (author), Detmar, S.B. (author), Cornel, M.C. (author), van der Flier, W.M. (author), Heutink, P. (author), Hol, E.M. (author), Rikkert, M.G.M.O. (author), van Duijn, C.M. (author), Janssens, A.C.J.W. (author), TNO Kwaliteit van leven (author)Alzheimer's disease (AD) is the most prevalent form of dementia and the number of cases is expected to increase exponentially worldwide. Three highly penetrant genes (AβPP, PSEN1, and PSEN2) explain only a small number of AD cases with a Mendelian transmission pattern. Many genes have been analyzed for association with non-Mendelian AD, but the...article 2010
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Pronk, A. (author), Preller, L. (author), Doekes, G. (author), Wouters, I.M. (author), Rooijackers, J. (author), Lammers, J.-W. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Associations have been observed between exposure to isocyanates, consisting mainly of oligomers, and respiratory symptoms and isocyanate specific sensitisation in spray painters. The aim of the present study was to assess associations between isocyanate exposure and more objective respiratory effect measures such as bronchial hyperresponsiveness...article 2009
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Bansal, S. (author), Gaspari, M. (author), Raj, H.G. (author), Kumar, A. (author), Cuda, G. (author), Verheij, E. (author), Tyagi, Y.K. (author), Ponnan, P. (author), Rastogi, R.C. (author), Parmar, V.S. (author), TNO Kwaliteit van Leven (author)Our earlier investigations identified acetoxy drug: protein transacetylase (TAase), a unique enzyme in the endoplasmic reticulum (ER) catalyzing the transfer of acetyl groups from polyphenolic acetates (PA) to certain functional proteins. Recently we have established the identity of TAase with ER protein calreticulin (CR) and subsequently...article 2008
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TNO Kwaliteit van Leven (author), Ceconi, C. (author), Fox, K.M. (author), Remme, W.J. (author), Simoons, M.L. (author), Bertrand, M. (author), Parrinello, G. (author), Kluft, C. (author), Blann, A. (author), Cokkinos, D. (author), Ferrari, R. (author)Objectives: EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease [EUROPA] demonstrates reduction in cardiovascular mortality and myocardial infarction for a possible vascular and antiatherosclerotic effect of angiotensin-converting enzyme (ACE) inhibition with perindopril. Our objective was to study...article 2007
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Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...article 2004
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Sengupta, S. (author), Toh, S.A. (author), Sellers, L.A. (author), Skepper, J.N. (author), Koolwijk, P. (author), Leung, H.W. (author), Yeung, H.W. (author), Wong, R.N.S. (author), Sasisekharan, R. (author), Fan, T.P.D. (author)Background-Ginseng is a commonly used nutraceutical. Intriguingly, existing literature reports both wound-healing and antitumor effects of ginseng extract through opposing activities on the vascular system. To elucidate this perplexity, we merged a chemical fingerprinting approach with a deconstructional study of the effects of pure molecules...article 2004
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Hoebe, K.H.N. (author), Witkamp, R.F. (author), Fink-Gremmels, J. (author), van Miert, A.S.J.P.A.M. (author), Monshouwer, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This study focuses on the importance of direct contact between Kupffer cells (KCs) and hepatocytes (HCs) during the hepatic inflammatory response using an in vitro approach. The lipopolysaccharide (LPS)-induced inflammatory response in monocultures of porcine HCs and KCs were compared with cocultures prepared either with direct contact between...article 2001
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van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)Chemicals/CAS: 5,6,7,8-tetrahydrobiopterin, 17528-72-2; Biopterin, 22150-76-1; Hydrogen Peroxide, 7722-84-1; Nitric Oxide Synthase Type II, EC 1.14.13.39; Nitric Oxide Synthase Type III, EC 1.14.13.39; Nitric Oxide Synthase, EC 1.14.13.39; Nitric Oxide, 10102-43-9; NOS3 protein, human, EC 1.14.13.39; Nos3 protein, mouse, EC 1.14.13.39article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Hoebe, K.H.N (author), Gonzalez-Ramon, N. (author), Nijmeijer, S.M. (author), Witkamp, R.F. (author), van Leengoed, L.A.M.G (author), van Miert, A.S.J.P.A.M (author), Monshouwer, M. (author)Pentoxifylline (PTX) has been shown to exert hepatoprotective effects in various liver injury models. However, little information is available about the effect of PTX on the hepatic acute phase response. In the present study, the effect of PTX on a lipopolysaccharide (LPS)-induced acute phase response in primary porcine liver cell cultures was...article 2001
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Dorrepaal, C.A. (author), van Bel, F. (author), Steendijk, P. (author), Shadid, M. (author), van de Velde, E.T. (author), Baan, J. (author), TNO Preventie en Gezondheid (author)The aim of the present study was to investigate the effect of immediate post-hypoxic-ischemic (HI) inhibition of nitric oxide synthesis by N(ω)- nitro-L-arginine (NLA) on cardiac function and reactive oxygen species production. Fifteen newborn lambs were subjected to severe HI. Upon resuscitation 5 received 10 mg NLA/kg, 4 40 mg NLA/kg and 6 a...article 2000