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Tsikas, D. (author), Hanff, E. (author), Bollenbach, A. (author), Kruger, R. (author), Pham, V.V. (author), Chobanyan-Jürgens, K. (author), Wedekind, D. (author), Arndt, T. (author), Jörns, A. (author), Berbée, J.F.P. (author), Princen, H.M.G. (author), Lücke, T. (author), Mariotti, F. (author), Huneau, J.F. (author), Ückert, S. (author), Frölich, J.C. (author), Lenzen, S. (author)We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO2−), an abundant reservoir of nitric oxide (NO) in tissues and cells. Impaired NO synthesis in the endothelium and decreased NO bioavailability in the circulation are considered major contributors to the development and progression of...article 2018
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Tsikas, D. (author), Pham, V.V. (author), Suchy, M.T. (author), van de Ree, M.A. (author), Huisman, M.V. (author), Frölich, J.C. (author), Princen, H.M.G. (author)The present study describes the effects of atorvastatin on whole body synthesis of nitric oxide (NO), prostacyclin (PGI2), and thromboxane A2 (TxA2), on oxidative stress and nitrite/nitrate-related renal carbonic anhydrase (CA) activity in patients with type 2 diabetes mellitus (T2DM). A double-blind, randomized, placebo-controlled parallel...article 2015
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Bodin, J. (author), Kocbach Bølling, A. (author), Wendt, A. (author), Eliasson, L. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development of diabetes in non-obese diabetic (NOD) mice. Here, we hypothesized that...article 2015
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Hafkamp-de Groen, E. (author), van der Valk, R.J.P. (author), Mohangoo, A.D. (author), van der Wouden, J.C. (author), Duijts, L. (author), Jaddoe, V.W. (author), Hofman, A. (author), de Koning, H.J. (author), de Jongste, J.C. (author), Raat, H. (author)Objectives: This study aimed to evaluate the effectiveness of systematic assessment of asthma-like symptoms and environmental tobacco smoke (ETS) exposure during regular preventive well-child visits between age 1 and 4 years by wellchild professionals. Methods: Sixteen well-child centres in Rotterdam, the Netherlands, were randomised into 8...article 2014
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Wolterbeek, A.P.M. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Piersma, A.H. (author), van Loveren, H. (author)The susceptibility of developing immune system to chemical disruption warrants the assessment of immune parameters in reproductive and developmental testing protocols. In this study, a wide range of immune endpoints was included in an extended one-generation reproduction toxicity study (EOGRTS) design to determine the relative sensitivity of...article 2013
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Offermans, P. (author), Crego-Calama, M. (author), Brongersma, S.H. (author)Vertical InAs nanowires are contacted in situ using an air-bridge construction and functionalized with a metalloporphyrin (Hemin). The response of bare and functionalized vertical InAs nanowire arrays to ppb-level concentrations of NO2 and NO is demonstrated. Hemin enhances the response to NO whereas NO2 is also detected without...article 2012
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Knoben, W. (author), Crego-Calama, M. (author), Brongersma, S.H. (author)The nitric oxide (NO) binding properties of monolayers of four different protoporphyrins IX adsorbed on aluminum oxide surfaces have been investigated. XPS and AFM results are consistent with the presence of a monolayer of porphyrins, bound to the surface by their carboxylic acid groups and with the porphine ring oriented more or less...article 2012
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Willems, F.P.T. (author), Cloudt, R.P.M. (author)Selective catalytic reduction (SCR) is a promising diesel aftertreatment technology that enables low nitrogen oxides (NOx) tailpipe emissions with relatively low fuel consumption. Future emission legislation is pushing the boundaries for SCR control systems to achieve high NOx conversion within a tailpipe ammonia (NH3) slip constraint, and to...article 2011
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Meijerink, J. (author), Plastina, P. (author), Vincken, J.P. (author), Poland, M. (author), Attya, M. (author), Balvers, M. (author), Gruppen, H. (author), Gabriele, B. (author), Witkamp, R.F. (author)Several mechanisms have been proposed for the positive health effects associated with dietary consumption of long-chain n-3 PUFA (n-3 LC-PUFA) including DHA (22 : 6n-3) and EPA (20 : 5n-3). After dietary intake, LC-PUFA are incorporated into membranes and can be converted to their corresponding N-acylethanolamines (NAE). However, little is known...article 2011
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Andringa, A-M. (author), Spijkman, M-J. (author), Mathijssen, S.G.J. (author), Smits, E.C.P. (author), van Hal, P.A. (author), Setayesh, S. (author), Willard, N.P. (author), Borshchev, O.V. (author), Ponomarenko, S.A. (author), Blom, P.W.M. (author), de Leeuw, D.M. (author)A new sensitive gas sensor based on a self-assembled monolayer field-effect transistor (SAMFET) was used to detect the biomarker nitric oxide. A SAMFET based sensor is highly sensitive because the analyte and the active channel are separated by only one monolayer. SAMFETs were functionalised for direct NO detection using iron porphyrin as a...article 2010
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Mihaescu, R. (author), Detmar, S.B. (author), Cornel, M.C. (author), van der Flier, W.M. (author), Heutink, P. (author), Hol, E.M. (author), Rikkert, M.G.M.O. (author), van Duijn, C.M. (author), Janssens, A.C.J.W. (author), TNO Kwaliteit van leven (author)Alzheimer's disease (AD) is the most prevalent form of dementia and the number of cases is expected to increase exponentially worldwide. Three highly penetrant genes (AβPP, PSEN1, and PSEN2) explain only a small number of AD cases with a Mendelian transmission pattern. Many genes have been analyzed for association with non-Mendelian AD, but the...article 2010
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Pronk, A. (author), Preller, L. (author), Doekes, G. (author), Wouters, I.M. (author), Rooijackers, J. (author), Lammers, J.-W. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)Associations have been observed between exposure to isocyanates, consisting mainly of oligomers, and respiratory symptoms and isocyanate specific sensitisation in spray painters. The aim of the present study was to assess associations between isocyanate exposure and more objective respiratory effect measures such as bronchial hyperresponsiveness...article 2009
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Dragomir, O.E. (author), Tummers, M.J. (author), van Veen, E.H. (author), van der Heijden, A.E.D.M. (author), Roekaerts, D.J.E.M. (author), TNO Defensie en Veiligheid (author)This paper presents the results of a series of experiments on the condensed phase decomposition and the gas phase combustion of hydrazinium nitroformate (HNF). The experiments include SEM analysis of quenched samples that showed evidence of the formation of a foam layer. FTIR spectrometry and mass spectrometry provide details on species...article 2009
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Appeldoorn, M.M. (author), Venema, D.P. (author), Peters, T.H.F. (author), Koenen, M.E. (author), Arts, I.C.W. (author), Vincken, J.-P. (author), Gruppen, H. (author), Keuer, J. (author), Hollman, P.C.H. (author), TNO Kwaliteit van Leven (author)The vasorelaxing properties of chocolate and wine might relate to the presence of phenolic compounds. One of the potential mechanisms involved is stimulation of endothelial nitric oxide (NO) production, as NO is a major regulator of vasodilatation. This study aimed to develop an in vitro assay using the hybrid human endothelial cell line EA...article 2009
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Bansal, S. (author), Gaspari, M. (author), Raj, H.G. (author), Kumar, A. (author), Cuda, G. (author), Verheij, E. (author), Tyagi, Y.K. (author), Ponnan, P. (author), Rastogi, R.C. (author), Parmar, V.S. (author), TNO Kwaliteit van Leven (author)Our earlier investigations identified acetoxy drug: protein transacetylase (TAase), a unique enzyme in the endoplasmic reticulum (ER) catalyzing the transfer of acetyl groups from polyphenolic acetates (PA) to certain functional proteins. Recently we have established the identity of TAase with ER protein calreticulin (CR) and subsequently...article 2008
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Beerkens, R.G.C. (author), van Limpt, J.A.C. (author), TNO Industrie en Techniek (author)The mechanism of nitrogen oxide (NOx) formation in combustion chambers of glass furnaces is briefly described. The most important parameters governing the NOx emissions of glass furnaces are discussed. Elimination or minimisation of conditions that cause the formation of nitrogen oxides in regenerative furnaces have been tested in industrial...article 2008
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TNO Kwaliteit van Leven (author), Ceconi, C. (author), Fox, K.M. (author), Remme, W.J. (author), Simoons, M.L. (author), Bertrand, M. (author), Parrinello, G. (author), Kluft, C. (author), Blann, A. (author), Cokkinos, D. (author), Ferrari, R. (author)Objectives: EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease [EUROPA] demonstrates reduction in cardiovascular mortality and myocardial infarction for a possible vascular and antiatherosclerotic effect of angiotensin-converting enzyme (ACE) inhibition with perindopril. Our objective was to study...article 2007
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TNO Bouw en Ondergrond (author), Pilegaard, K. (author), Skiba, U. (author), Ambus, P. (author), Beier, C. (author), Brüggemann, N. (author), Butterbach-Bahl, K. (author), Dick, J. (author), Dorsey, J. (author), Duyzer, J. (author), Gallagher, M. (author), Gasche, R. (author), Horvath, L. (author), Kitzler, B. (author), Leip, A. (author), Pihlatie, M.K. (author), Rosenkranz, P. (author), Seufert, G. (author), Vesala, T. (author), Westrate, H. (author), Zechmeister-Boltenstern, S. (author)Soil emissions of NO and N2O were measured continuously at high frequency for more than one year at 15 European forest sites as part of the EU-funded project NOFRETETE. The locations represent different forest types (coniferous/deciduous) and different nitrogen loads. Geographically they range from Finland in the north to Italy in the south and...article 2006
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Rookmaaker, M.B. (author), Verhaar, M.C. (author), Loomans, C.J.M. (author), Verloop, R. (author), Peters, E. (author), Westerweel, P.E. (author), Murohara, T. (author), Staal, F.J.T. (author), van Zonneveld, A.J. (author), Koolwijk, P. (author), Rabelink, T.J. (author), van Hinsbergh, V.W.M. (author), TNO Kwaliteit van Leven (author)Objective - Emerging evidence suggests that human blood contains bone marrow (BM)-derived endothelial progenitor cells that contribute to postnatal neovascularization. Clinical trials demonstrated that administration of BM-cells can enhance neovascularization. Most studies, however, used crude cell populations. Identifying the role of different...article 2005
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Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...article 2004
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