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Kuper, C.F. (author), van Zijverden, M. (author), Klaassen, C. (author), Tegelenbosch-Schouten, M. (author), Wolterbeek, A.P.M. (author), TNO Kwaliteit van Leven (author)The effects of cyclosporin A (CY) and cyclophosphamide (CPS) on Peyer's patches (PP) were studied in Wistar rats, exposed in utero and neonatally or during adult age. In one study, pregnant dams received 5 or 15 mg/kg bw/day CY from gestation day 6 to day 21 of lactation. In two other studies, animals were exposed at young adult age: female rats...article 2007
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van den Akker-van Marle, M.E. (author), Rijnders, M.E.B. (author), Amelink-Verburg, M.P. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)COBJECTIVE: To estimate the costs and effects of different treatment strategies with intrapartum antibiotic prophylaxis to prevent early-onset group B streptococcal (GBS) disease in the Netherlands. The treatment strategies include a risk-based strategy, a screening-based strategy, a combined screening/risk-based strategy and the current Dutch...article 2006
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Peters, J.W.B. (author), Koot, H.M. (author), Grunau, R.E. (author), de Boer, J. (author), van Druenen, M.J. (author), Tibboel, D. (author), Duivenvoorden, H.J. (author), TNO Preventie en Gezondheid (author)Objective: The objectives of this study were to: (1) evaluate the validity of the Neonatal Facial Coding System (NFCS) for assessment of postoperative pain and (2) explore whether the number of NFCS facial actions could be reduced for assessing postoperative pain. Design: Prospective, observational study. Patients: Thirty-seven children (0-18...article 2003
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Walther, F.J. (author), den Ouden, A.L. (author), Verloove-Vanhorick, S.P. (author)In 1983, Dutch pediatricians collaborated on a national level and collected perinatal data on 1338 liveborn infants with a gestational age <32 weeks and/or a birthweight <1500 g (project on preterm and small for gestational age infants, POPS). Their outcome was assessed at 2 years of age by their pediatricians, at 5 years by a team of...article 2000