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Krishnan, S. (author), Vermeulen, R. (author), Pronk, A. (author), Gyori, B.M. (author), Bachman, J.A. (author), Vlaanderen, J. (author), Stierum, R. (author)BACKGROUND: Mechanistic data is increasingly used in hazard identification of chemicals. However, the volume of data is large, challenging the efficient identification and clustering of relevant data. OBJECTIVES: We investigated whether evidence identification for hazard assessment can become more efficient and informed through an automated...article 2022
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Sewell, F. (author), Strupp, C. (author), van der Laan, J.W. (author), Wolf, D.C. (author), Wolterink, G. (author), Woutersen, R. (author), Zvonar, Z. (author), Heusinkveld, H. (author), Braakhuis, H. (author)Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive power and results has been scientifically challenged. With increased availability of innovative...article 2020
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Luijten, M. (author), Olthof, E.D. (author), Hakkert, B.C. (author), Rorije, E. (author), van der Laan, J.-W. (author), Woutersen, R.A. (author), van Benthem, J. (author)Assessment of genotoxic and carcinogenic potential is considered one of the basic requirements when evaluating possible human health risks associated with exposure to chemicals. Test strategies currently in place focus primarily on identifying genotoxic potential due to the strong association between the accumulation of genetic damage and cancer...article 2016
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- de Marchi, T. (author), Braakman, R.B.H. (author), Stingl, C. (author), van Duijn, M.M. (author), Smid, M. (author), Foekens, J.A. (author), Luider, T.M. (author), Martens, J.W.M. (author), Umar, A. (author) article 2016
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Buist, H.E. (author), Devito, S. (author), Goldbohm, R.A. (author), Stierum, R.H. (author), Venhorst, J. (author), Kroese, E.D. (author)Carbon capture and storage (CCS) technologies are considered vital and economic elements for achieving global CO2 reduction targets, and is currently introduced worldwide (for more information on CCS, consult for example the websites of the International Energy Agency (http://www.iea.org/topics/ccs/) and the Global CCS Institute (http://www...article 2015
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Koppes, L.J.J. (author), Geuskens, G.A. (author), Pronk, A. (author), Vermeulen, R.C.H. (author), de Vroome, E.M.M. (author)Experimental studies in animals indicate that disruption of the circadian rhythm is carcinogenic, and night work has been suggested to be a probable breast cancer cause in humans. Findings among humans, however are inconsistent, often gathered with retrospective study designs, and only based on specific populations, such as nurses. We used data...article 2014
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Heinen, M.M. (author), Verhage, B.A.J. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), Schouten, H.C. (author), van den Brandt, P.A. (author)Results from epidemiological studies suggest that alcohol drinkers have a decreased risk of lymphoid neoplasms, whereas results for myeloid neoplasms are inconsistent. However, most of these studies have used retrospective data. We examined prospectively whether alcohol consumption decreases the risk of both lymphoid and myeloid neoplasms,...article 2013
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Simons, C.C.J.M. (author), Hughes, L.A.E. (author), van Engeland, M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author)We investigated occupational energy expenditure and sitting time in the longest held job (in men only), nonoccupational physical activity, and former sports participation in relation to colorectal cancer endpoints. The Netherlands Cohort Study includes 120,852 participants who completed a self-administered questionnaire in 1986 when they were...article 2013
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Zeegers, M.P. (author), Nekeman, D. (author), Khan, H.S. (author), van Dijk, B.A.C. (author), Goldbohm, R.A. (author), Schalken, J. (author), Shajahan, S. (author), Pearlman, A. (author), Oddoux, C. (author), van den Brandt, P.A. (author), Schouten, L.J. (author), Ostrer, H. (author), TNO Preventie en Gezondheid (author)Background:Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate...article 2013
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van Keulen, H.M. (author), Otten, W. (author), Ruiter, R.A.C. (author), van Steenbergen, J. (author), Paulussen, T.W.G.M. (author), Fekkes, M. (author), Paulussen, T.W.G.M. (author)Onderzoeken welke factoren deelname aan de HPV-vaccinatie bepaalden in 2009 en 2010. Opzet Retrospectief dwarsdoorsnede-onderzoek. Methode Uit een telepanel werden aselecte steekproeven getrokken van Nederlandse meisjes die in 2009 en 2010 werden opgeroepen voor de HPV-vaccinatie, evenals hun moeders. Gegevens werden verzameld via een online...article 2013
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Geybels, M.S. (author), Verhage, B.A.J. (author), van Schooten, F.J. (author), Goldbohm, A. (author), van den Brandt, P.A. (author)BACKGROUND: Selenium may prevent advanced prostate cancer (PCa), but most studies on this topic were conducted in populations with moderate to high selenium status. We investigated the association of toenail selenium, reflecting long-term selenium exposure, and advanced PCa risk in a population from the Netherlands where low selenium status is...article 2013
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Goede, J. (author), Hofman, H.A. (author), Wagenvoort, A.M. (author), Pierik, F.H. (author), Hack, W.W.M. (author)Background: Testicular microlithiasis (TM) is a relatively uncommon and usually asymptomatic condition that is characterized by multiple 1-3 mm nonshadowing echogenic foci within the parenchyma of the testis. Objectives: The prevalence of testicular microlithiasis was assessed retrospectively in males ranging from 0-18 years who had been...article 2012
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Keszei, A.P. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)Background: Prospective data on red and processed meat in relation to risk of subtypes of esophageal and gastric cancer are scarce. We present analyses of association between red and processed meat and the risk of esophageal and gastric cancer subtypes within The Netherlands Cohort Study on Diet and Cancer. Design: 120 852 individuals aged 55-69...article 2012
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Koushik, A. (author), Spiegelman, D. (author), Albanes, D. (author), Anderson, K.E. (author), Bernstein, L. (author), van den Brandt, P.A. (author), Bergkvist, L. (author), English, D.R. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Genkinger, J.M. (author), Giles, G.G. (author), Goldbohm, R.A. (author), Horn-Ross, P.L. (author), Männistö, S. (author), McCullough, M.L. (author), Millen, A.E. (author), Miller, A.B. (author), Robien, K. (author), Rohan, T.E. (author), Schatzkin, A. (author), Shikany, J.M. (author), Stolzenberg-Solomon, R.Z. (author), Willett, W.C. (author), Wolk, A. (author), Ziegler, R.G. (author), Smith-Warner, S.A. (author)Fruit and vegetable intake may protect against pancreatic cancer, since fruits and vegetables are rich in potentially cancer-preventive nutrients. Most case-control studies have found inverse associations between fruit and vegetable intake and pancreatic cancer risk, although bias due to reporting error cannot be ruled out. In most prospective...article 2012
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Steevens, J. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)Prospective epidemiologic data on vegetables and fruits consumption and risk of subtypes of esophageal and gastric cancer are sparse. We studied the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric...article 2011
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Bongaerts, B.W.C. (author), de Goeij, A.F.P.M. (author), Wouters, K.A.D. (author), van Engeland, M. (author), Gottschalk, R.W.H. (author), van Schooten, F.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author)Within the Netherlands Cohort Study (1986), we examined associations between alcohol consumption, the alcohol dehydrogenase 1C (ADH1C) genotype, and risk of colorectal cancer (CRC). After a follow-up period of 7.3 years, 594 CRC cases with information on genotype and baseline alcohol intake were available for analyses. Adjusted incidence rate...article 2011
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Hughes, L.A.E. (author), Simons, C.C.J.M. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), van Engeland, M. (author), Weijenberg, M.P. (author)A large body size may differentially influence risk of colorectal cancer (CRC) by anatomic location. The Netherlands Cohort Study includes 120,852 men and women aged 55-69 years who self-reported weight, height, and trouser/skirt size at baseline (1986), as well as weight at age 20 years. Derived variables included body mass index (BMI; weight ...article 2011
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Reproductive and hormonal factors in association with ovarian cancer in the Netherlands cohort studyBraem, M.G.M. (author), Onland-Moret, N.C. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Peeters, P.H.M. (author), Kruitwagen, R.F.P.M. (author), Schouten, L.J. (author), TNO Kwaliteit van Leven (author)Parity, oral contraceptive use, and hysterectomy are known to protect against ovarian cancer, whereas the effect of other reproductive factors remains unclear. The authors investigated the association between several reproductive and hormonal factors and the risk of epithelial invasive ovarian cancer among postmenopausal women participating in...article 2010
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Hughes, L.A.E. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), d Goeij, A.F.P.M. (author), de Bruïne, A.P. (author), van Engeland, M. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)Background: Energy restriction during childhood and adolescence is suggested to lower colorectal cancer (CRC) risk. We investigated this in the Netherlands Cohort Study. Methods: Information on diet and other risk factors was collected by a baseline questionnaire in 1986 when cohort members were 55-69 years of age (n = 120 852). Three indicators...article 2010
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Smits, K.M. (author), Schouten, L.J. (author), Hudak, E. (author), Verhage, B. (author), van Dijk, B.A.C. (author), van de Hulsbergen - Kaa, C.A. (author), Goldbohm, R.A. (author), Oosterwijk, E. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Purpose: Body mass index (BMI) is an important risk factor for clear-cell renal cancer (cc-RCC). A common molecular alteration in cc-RCC is loss-of-function of the von Hippel-Lindau (VHL) gene. We evaluated the association between BMI and VHL mutations in cc-RCC by using data from the Netherlands Cohort Study (NLCS), a prospective study, which...article 2010