Searched for: subject%3A%22Myofibroblast%22
(1 - 7 of 7)
document
Ruiz-Zapata, A.M. (author), Heinz, A. (author), Kerkhof, M.H. (author), van de Westerlo-van Rijt, C. (author), Schmelzer, C.E.H. (author), Stoop, R. (author), Kluivers, K.B. (author), Oosterwijk, E. (author)
Fibroblast to myofibroblast differentiation is a key feature of wound-healing in soft tissues, including the vagina. Vaginal fibroblasts maintain the integrity of the vaginal wall tissues, essential to keep pelvic organs in place and avoid pelvic organ prolapse (POP). The micro-environment of vaginal tissues in POP patients is stiffer and has...
article 2020
document
González-Santamaría, J. (author), Villalba, M. (author), Busnadiego, O. (author), López-Olañeta, M.M. (author), Sandoval, P. (author), Snabel, J. (author), López-Cabrera, M. (author), Erler, J.T. (author), Hanemaaijer, R. (author), Lara-Pezzi, E. (author), Rodríguez-Pascual, F. (author)
Aims After myocardial infarction (MI), extensive remodelling of the extracellular matrix contributes to scar formation. While aiming to preserve tissue integrity, this fibrotic response is also associated with adverse events, including a markedly increased risk of heart failure, ventricular arrhythmias, and sudden cardiac death. Cardiac fibrosis...
article 2016
document
Blaauboer, M.E. (author), Boeijen, F.R. (author), Emson, C.L. (author), Turner, S.M. (author), Zandieh-Doulabi, B. (author), Hanemaaijer, R. (author), Smit, T.H. (author), Stoop, R. (author), Everts, V. (author)
Lung fibrosis is characterized by excessive deposition of extracellular matrix. This not only affects tissue architecture and function, but it also influences fibroblast behavior and thus disease progression. Here we describe the expression of elastin, type V collagen and tenascin C during the development of bleomycin-induced lung fibrosis. We...
article 2014
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Blaauboer, M.E. (author), Smit, T.H. (author), Hanemaaijer, R. (author), Stoop, R. (author), Everts, V. (author)
In lung fibrosis tissue architecture and function is severely hampered by myofibroblasts due to excessive deposition of extracellular matrix and tissue contraction. Myofibroblasts differentiate from fibroblasts under the influence of transforming growth factor (TGF) β<sub>1</sub> but this process is also controlled mechanically by cytoskeletal...
article 2011
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Rubbens, M.P. (author), Mol, A. (author), van Marion, M.H. (author), Hanemaaijer, R. (author), Bank, R.A. (author), Baaijens, F.P.T. (author), Bouten, C.V.C. (author), TNO Kwaliteit van Leven (author)
Similar to native cardiovascular tissues, the mechanical properties of engineered cardiovascular constructs depend on the composition and quality of the extracellular matrix, which is a net result of matrix remodeling processes within the tissue. To improve tissue remodeling, and hence tissue mechanical properties, various mechanical...
article 2009
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Balguid, A. (author), Mol, A. (author), van Marion, M.H. (author), Bank, R.A. (author), Bouten, C.V.C. (author), Baaijens, F.P.T. (author), TNO Kwaliteit van Leven (author)
Despite the attractive features of nanofibrous scaffolds for cell attachment in tissue-engineering (TE) applications, impeded cell ingrowth has been reported in electrospun scaffolds. Previous findings have shown that the scaffold can function as a sieve, keeping cells on the scaffold surface, and that cell migration into the scaffold does not...
article 2009
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TNO Kwaliteit van Leven (author), Hawinkels, L.J.A.C. (author), Verspaget, H.W. (author), van Duijn, W. (author), van der Zon, J.M. (author), Zuidwijk, K. (author), Kubben, F.J.G.M. (author), Verheijen, J.H. (author), Hommes, D.W. (author), Lamers, C.B.H.W. (author), Sier, C.F.M. (author)
Transforming growth factor-beta1 (TGF-beta1), a tumour suppressing as well as tumour-promoting cytokine, is stored as an extracellular matrix-bound latent complex. We examined TGF-beta1 activation and localisation of TGF-beta1 activity in gastric cancer. Gastric tumours showed increased stromal and epithelial total TGF-beta1 staining by...
article 2007
Searched for: subject%3A%22Myofibroblast%22
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