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Kraaijeveld, A.O. (author), de Jager, S.C.A. (author), de Jager, W.J. (author), Prakken, B.J. (author), McColl, S.R. (author), Haspels, I. (author), Putter, H. (author), van Berkel, T.J.C. (author), Nagelkerken, L. (author), Jukema, J.W. (author), Biessen, E.A.L. (author), TNO Kwaliteit van Leven (author)BACKGROUND - Chemokines play an important role in atherogenesis and in ischemic injury and repair; however, prospective data on individual chemokines in unstable angina pectoris (UAP) are scarce. Therefore, we assessed chemokine patterns in a prospective cohort of patients with UAP. METHODS AND RESULTS - Plasma samples of 54 patients with...article 2007
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- Beulens, J.W.J. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author) article 2006
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Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...article 2004
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Mohrschladt, M.F. (author), Westendorp, R.G.J. (author), Gevers Leuven, J.A. (author), Smelt, A.H.M. (author), Gaubius Instituut TNO (author)Patients with familial hypercholesterolemia (FH) are at an increased risk of premature cardiovascular disease (CVD). The benefits of statin therapy are not well known since no placebo controlled studies have been performed in these patients. The aim of this study was to determine the CVD event and mortality risk in statin-treated patients with...article 2004
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de Maat, M.P.M. (author), Green, F. (author), de Knijff, P. (author), Jespersen, J. (author), Kluft, C. (author), Gaubius Instituut TNO (author)Increased plasma factor VII coagulant activity (FVII:C) has been associated with the risk of ischemic heart disease (IHD). Differences in plasma FVII:C among individuals are associated with three common polymorphisms in the FVII gene. Therefore, we investigated FVII polymorphisms in four populations that differ in their risk of developing...article 1997
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TNO Preventie en Gezondheid (author), Biasucci, L.M. (author), Liuzzo, G. (author), Caligiuri, G. (author), Quaranta, G. (author), Andreotti, F. (author), Sperti, G. (author), van de Greef, W. (author), Rebuzzi, A.G. (author), Kluft, C. (author), Maseri, A. (author)Background: Although a major role of coronary thrombosis in the pathogenesis of unstable angina has been demonstrated, the results of a series of studies have suggested that activation of the hemostatic system may not be confined to ischemic episodes. The purpose of this study was to investigate the temporal relation between ischemic episodes...article 1996