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Fuijkschot, W.W. (author), Morrison, M.C. (author), Zethof, I.P.A. (author), Krijnen, P.A.J. (author), Kleemann, R. (author), Niessen, H.W.M. (author), Smulders, Y.M. (author)Background and Aims: Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intraplaque inflammation. We evaluated whether...article 2018
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Woudstra, L. (author), Meinster, E. (author), van Haren, L. (author), Kay, A.M. (author), Kooman, M. (author), Belien, J.A.M. (author), Morrison, M.C. (author), van Rossum, A.C. (author), Helder, M.N. (author), Juffermans, J.M. (author), Niessen, H.W.M. (author), Krijnen, P.A.J. (author)Background aims. After a myocardial infarction (MI) atherosclerosis is accelerated leading to destabilization of the atherosclerotic plaque. mesenchymal stromal cells are a promising therapeutic option for atherosclerosis. Previously, we demonstrated a novel stem cell delivery technique, with adipose stem cells coupled to microbubbles (i.e.,...article 2018
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Fuijkschot, W.W. (author), Morrison, M.C. (author), van der Linden, R. (author), Krijnen, P.A.J. (author), Zethof, I.P.A. (author), Theyse, L.F.H. (author), Kleemann, R. (author), Niessen, H.W.M. (author), Smulders, Y.M. (author)Background and aims Observational studies show a peak incidence of cardiovascular events after major surgery. For example, the risk of myocardial infarction increases 25-fold early after hip replacement. The acuteness of this increased risk suggests abrupt enhancement in plaque vulnerability, which may be related to intra-plaque inflammation,...article 2016
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González-Santamaría, J. (author), Villalba, M. (author), Busnadiego, O. (author), López-Olañeta, M.M. (author), Sandoval, P. (author), Snabel, J. (author), López-Cabrera, M. (author), Erler, J.T. (author), Hanemaaijer, R. (author), Lara-Pezzi, E. (author), Rodríguez-Pascual, F. (author)Aims After myocardial infarction (MI), extensive remodelling of the extracellular matrix contributes to scar formation. While aiming to preserve tissue integrity, this fibrotic response is also associated with adverse events, including a markedly increased risk of heart failure, ventricular arrhythmias, and sudden cardiac death. Cardiac fibrosis...article 2016
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Kühnast, S. (author), Fiocco, M. (author), van der Hoorn, J.W.A. (author), Princen, H.M.G. (author), Jukema, J.W. (author)Non-HDL-cholesterol is well recognised as a primary causal risk factor in cardiovascular disease. However, despite consistent epidemiological evidence for an inverse association between HDL-C and coronary heart disease, clinical trials aimed at raising HDL-C (AIM-HIGH, HPS2-THRIVE, dal-OUTCOMES) failed to meet their primary goals. This...article 2015
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Louwe, M.C. (author), Karper, J.C. (author), de Vries, M.R. (author), Nossent, A.Y. (author), Bastiaansen, A.J.N.M. (author), van der Hoorn, J.W.A. (author), Willems Van Dijk, K. (author), Rensen, P.C.N. (author), Steendijk, P. (author), Smit, J.W.A. (author), Quax, P.H.A. (author)Background Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signaling domain that competitively inhibits TLR4-signaling. Thus, we hypothesized that RP105 deficiency, by...article 2014
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Louwe, M.C. (author), Karper, J.C. (author), de Vries, M.R. (author), Bastiaansen, A.J.N.M. (author), van der Hoorn, J.W.A. (author), Willems Van Dijk, K. (author), Rensen, P.C.N. (author), Steendijk, P. (author), Smit, J.W.A. (author), Quax, P.H.A. (author)Purpose: Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signalling domain that competitively inhibits TLR4-signalling. Thus, we hypothesized that RP105 deficiency, by...article 2014
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van den Borne, S.W.M. (author), Cleutjens, J.P.M. (author), Hanemaaijer, R. (author), Creemers, E.E. (author), Smits, J.F.M. (author), Daemen, M.J.A.P. (author), Blankesteijn, W.M. (author), TNO Kwaliteit van Leven (author)Background: Infarct rupture is a usually fatal complication of myocardial infarction (MI), for which no molecular mechanism has been described in humans. Experimental evidence in mouse models suggests that the degradation of the extracellular matrix by matrix metalloproteinases (MMPs) plays an important role in infarct rupture. The present study...article 2009
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- TNO Kwaliteit van Leven (author), Timmers, L. (author), Sluijter, J.P.G. (author), van Keulen, J.K. (author), Hoefer, I.E. (author), Nederhoff, M.G.J. (author), Goumans, M.J. (author), Doevendans, P.A. (author), van Echteld, C.J.A. (author), Joles, J.A. (author), Quax, P.H. (author), Piek, J.J. (author), Pasterkamp, G. (author), de Kleijn, D.P.V. (author) article 2008
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Miedema, H.M.E. (author), TNO Bouw (author)This paper presents an overview of the following exposure-response relationships that can be used for assessing the impact of environmental noise: • Lden - annoyance relationships from the EU Position Paper on exposure-response relationships for transportation noise annoyance (EC-WG/2 2002; Env. Health Persp. 2001, 109 (4) 409-416). In addition,...conference paper 2007
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Zacharowski, K. (author), Zacharowski, P.A. (author), Friedl, P. (author), Mastan, P. (author), Koch, A. (author), Boehm, O. (author), Rother, R.P. (author), Reingruber, S. (author), Henning, R. (author), Emeis, J.J. (author), Petzelbauer, P. (author), TNO Kwaliteit van Leven (author)Many compounds have been shown to prevent reperfusion injury in various animal models, although to date, translation into clinic has revealed several obstacles. Therefore, the National Heart, Lung, and Blood Institute convened a working group to discuss reasons for such failure. As a result, the concept of adequately powered, blinded, randomized...article 2007
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Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...article 2004
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Gómez-Aracena, J. (author), Martin-Moreno, J.M. (author), Riemersma, R.A. (author), Bode, P. (author), Gutiérrez-Bedmar, M. (author), Gorgojo, L. (author), Kark, J.D. (author), Garcia-Rodríguez, A. (author), Gomez-Gracia, E. (author), Kardinaal, A.F.M. (author), Aro, A. (author), van 't Veer, P. (author), Wedel, H. (author), Kok, F.J. (author), Fernández-Crehuet, J. (author)The association between scandium status and risk of acute myocardial infarction (MI) was examined in a multicentre case control study in 10 centres from Europe and Israel. Scandium in toenails was assessed in 684 cases and 724 controls less than 70 years of age. Mean concentrations of toenail scandium were 6.74 μg/kg in cases and 7.75 μg/kg in...article 2002
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Guallar, E. (author), Aro, A. (author), Jiménez, F.J. (author), Martín-Moreno, J.M. (author), Salminen, I. (author), van 't Veer, P. (author), Kardinaal, A.F.M. (author), Gömez-Aracena, J. (author), Martin, B.C. (author), Kohlmeier, L. (author), Kark, J.D. (author), Mazaev, V.P. (author), Ringstad, J. (author), Guillén, J. (author), Riemersma, R.A. (author), Huttunen, J.K. (author), Thamm, M. (author), Kok, F.J. (author)Omega-3 fatty acids have potential antiatherogenic, antithrombotic, and antiarrhythmic properties, but their role in coronary heart disease remains controversial. To evaluate the association of omega-3 fatty acids in adipose tissue with the risk of myocardial infarction in men, a case-control study was conducted in eight European countries and...article 1999
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Klipstein-Grobusch, K. (author), Grobbee, D.E. (author), den Breeijen, J.H. (author), Boeing, H. (author), Hofman, A. (author), Witteman, J.C.M. (author)Free iron has been implicated in lipid peroxidation and ischemic myocardial damage, and it has been suggested that iron is an independent risk factor for myocardial infarction. The authors investigated whether dietary iron is associated with an increased risk of fatal and nonfatal myocardial infarction in the Rotterdam Study, a community-based...article 1999
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Su, L.C.J. (author), Bui, M. (author), Kardinaal, A. (author), Gomez-Aracena, J. (author), Martin-Moreno, J. (author), Martin, B. (author), Thamm, M. (author), Simonsen, N. (author), van 't Veer, P. (author), Kok, F. (author), Strain, S. (author), Kohlmeier, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids and tocopherols. The data consisted of samples from 91 men and 122 women, ages 45-70 years, from the control group of the European Community...article 1998
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van der Bom, J.G. (author), de Maat, M.P.M. (author), Bots, M.L. (author), Haverkate, F. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Kluft, C. (author), Grobbee, D.E. (author), Gaubius Instituut TNO (author)An association between increased plasma fibrinogen and an increased risk for myocardial infarction (MI) is well established, but the nature of this association is subject to debate. Our aim was to shed light on the potentially causal nature of this association. We examined whether increased plasma fibrinogen, due to a condition that is...article 1998
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Zito, F. (author), di Castelnuovo, A. (author), Amore, C. (author), D'Orazio, A. (author), Donati, M.B. (author), Iacoviello, L. (author), Gaubius Instituut TNO (author)The aim of this study was to investigate the association of the Bcl I β-chain fibrinogen polymorphism with the risk of acute myocardial infarction (AMI) and its relationship with fibrinogen levels in the Italian population. We studied 102 AMI patients, selected within the framework of the GISSI-2 trial, who had a familial history of arterial...article 1997
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van der Bom, J.G. (author), de Knijff, P. (author), Haverkate, F. (author), Bots, M.L. (author), Meijer, P. (author), de Jong, P.T.V.M. (author), Hofman, A. (author), Kluft, C. (author), Grobbee, D.E. (author), Gaubius Instituut TNO (author)Background: Impaired fibrinolytic capacity, as assessed by euglobulin clot lysis time or plasma concentration of fibrinolytic parameters, has been associated with an increased risk of myocardial infarction (MI). We studied the association of a polymorphism in the gene for TPA and of plasma concentrations of TPA (antigen and activity) with the...article 1997
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Juhan-Vague, I. (author), Pyke, S.D.M. (author), Alessi, M.C. (author), Jespersen, J. (author), Haverkate, F. (author), Thompson, S.G. (author), Hematology Laboratory, CHU Timone, Marseille, France Medical Statistics Unit, London (UK) Sch. of Hyg./Trop. Med. Centralsygehuset, Esbjerg, Denmark Gaubius Laboratory Hematology Laboratory, CHU Timone, 13385 Marseille Cedex 5, France TNO Preventie en Gezondheid (author)Background: Disturbances of the fibrinolytic system that lead to decreased removal of fibrin deposits may be important risk factors for coronary thrombosis. There is as yet no consensus on the prognostic value of fibrinolytic parameters, which may be attributed in part to the choice of confounding variables controlled for. Methods and Results:...article 1996
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