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van Rooij, L. (author), Elrofai, H.B.H. (author), Philippens, M.M.G.M. (author), Daanen, H.A.M. (author)It is important to understand human kinematics and muscle activation patterns in emergency maneuvers for the design of safety systems and for the further development of human models. The objective of this study was to quantify kinematic behavior and muscle activation in simulated steering tests in several realistic conditions. In total 108 tests...article 2013
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van Dieën, J.H. (author), Putten, E.P. (author), Kingma, I. (author), de Looze, M.P. (author), TNO Kwaliteit van Leven (author)This study was designed to determine whether trunk extensor fatigue occurs during low-level activity and whether this is associated with a drop in muscle tissue oxygenation. Electromyography (EMG) feedback was used to impose constant activity in a part of the trunk extensor muscles. We hypothesized that electromyographic manifestations of...article 2009
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de Korte, E.M. (author), de Kraker, H. (author), Bongers, P.M. (author), van Lingen, P. (author), TNO Kwaliteit van Leven (author)To study the effects of a tactile feedback signal in a computer mouse on reduction of hovering behaviour and consequently on changes in muscle load, productivity, comfort and user friendliness, a comparative, experimental study with repeated measures was conducted. Fifteen subjects performed five trials with different mouse actions and a...article 2008
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Bosch, T. (author), de Looze, M.P. (author), van Dieën, J.H. (author), TNO Kwaliteit van Leven (author)Optimization of the temporal aspects of task design requires a better understanding of the development of muscle fatigue in the neck and shoulder region over time. The objective of the study was to investigate this in two production companies and to determine the relationship between objective and subjective estimates of fatigue. Indicators of...article 2007
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van Weel, V. (author), Seghers, L. (author), de Vries, M.R. (author), Kuiper, E.J. (author), Schlingemann, R.O. (author), Bajema, I.M. (author), Lindeman, J.H.N. (author), van Delis-Diemen, P.M. (author), van Hinsbergh, V.W.M. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)OBJECTIVE - Vascular endothelial growth factor (VEGF)-induced stromal cell-derived factor-1 (SDF-1) has been implicated in angiogenesis in ischemic tissues by recruitment of CXCR4-positive bone marrow-derived circulating cells with paracrine functions in preclinical models. Here, evidence for this is provided in patients with peripheral artery...article 2007
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van Bezooijen, R.L. (author), Svensson, J.P. (author), Eefting, D. (author), Visser, A. (author), van der Horst, G. (author), Karperien, M. (author), Quax, P.H.A. (author), Vrieling, H. (author), Papapoulos, S.E. (author), ten Dijke, P. (author), Löwik, W.G.M.C. (author), TNO Kwaliteit van Leven (author)Sclerostin is an osteocyte-derived negative regulator of bone formation. It inhibits BMP-stimulated bone formation both in vitro and in vivo but has no direct effect on BMP signaling. Instead, sclerostin inhibits Wnt signaling that is required for BMP-stimulated osteoblastic differentiation. Introduction: Sclerostin is a member of the Dan family...article 2007
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Eefting, D. (author), Grimbergen, J.M. (author), de Vries, M.R. (author), van Weel, V. (author), Kaijzel, E.L. (author), Que, I. (author), Moon, R.T. (author), Löwik, C.W. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)For the successful application of RNA interference in vivo, it is desired to achieve (local) delivery of small interfering RNAs (siRNAs) and long-term gene silencing. Nonviral electrodelivery is suitable to obtain local and prolonged expression of transgenes. By intramuscular electrodelivery of a plasmid in which two opposing human polymerase...article 2007
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Visser, B. (author), van Dieën, J.H. (author), TNO Kwaliteit van Leven (author)A review of the literature on the pathophysiology of upper extremity muscle disorders (UEMDs) was performed. An overview is given of clinical findings and hypotheses on the pathogenesis of UEMDs. The literature indicates that disorders of muscle cells and limitations of the local circulation underlie UEMDs. However, these disorders identified do...article 2006
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Visser, B. (author), Nielsen, P.K. (author), de Kraker, H. (author), Smits, M. (author), Jensen, B.R. (author), Veeger, D. (author), van Dieën, J.H. (author), TNO Kwaliteit van Leven (author), KvL (author)The object of the current study was to determine whether static contraction of proximal musculature has an effect on the blood flow more distally in the upper extremity. Static contractions of muscles in the neck shoulder region at three levels (relaxed, shoulders elevated and shoulders elevated loaded with 4.95 kg each) were combined with...article 2006
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Boshuizen, H.C. (author), Stemmerik, L. (author), Westhoff, M.H. (author), Hopman-Rock, M. (author), TNO Kwaliteit van Leven (author)Elderly participants experiencing difficulty in chair rising and with a maximum knee-extensor torque below 87.5 N · m were randomized to different versions of a strength-training program for the knee-extensors: to a high-guidance group (HG; two group sessions supervised by a physical therapist and one unsupervised home session per week, n = 17),...article 2005
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TNO Kwaliteit van Leven (author), Heijboer, A.C. (author), Donga, E. (author), Voshol, P.J. (author), Dang, Z.C. (author), Havekes, L.M. (author), Romijn, J.A. (author), Corssmit, E.P.M. (author)Fasting readily induces hepatic steatosis. Hepatic steatosis is associated with hepatic insulin resistance. The purpose of the present study was to document the effects of 16 h of fasting in wild-type mice on insulin sensitivity in liver and skeletal muscle in relation to 1) tissue accumulation of triglycerides (TGs) and 2) changes in mRNA...article 2005
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van Weel, V. (author), Deckers, M.M.L. (author), Grimbergen, J.M. (author), van Leuven, K.J.M. (author), Lardenoye, J.W.H.P. (author), Schlingemann, R.O. (author), van Nieuw Amerongen, G.P. (author), van Bockel, J.H. (author), van Hinsbergh, V.W.M. (author), Quax, P.H.A. (author), Gaubius Instituut TNO (author)Therapeutic angiogenesis using vascular endothelial growth factor (VEGF) is considered a promising new therapy for patients with arterial obstructive disease. Clinical improvements observed consist of improved muscle function and regression of rest pain or angina. However, direct evidence for improved vascularization, as evaluated by angiography...article 2004
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Visser, B. (author), de Looze, M.P. (author), de Graaff, M.P. (author), van Dieën, J.H. (author)The objective of the present study was to gain insight into the effects of precision demands and mental pressure on the load of the upper extremity. Two computer mouse tasks were used: an aiming and a tracking task. Upper extremity loading was operationalized as the myo-electric activity of the wrist flexor and extensor and of the trapezius...article 2004
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TNO Preventie en Gezondheid (author), Schaap, F.G. (author), Rensen, P.C.N. (author), Voshol, P.J. (author), Vrins, C. (author), van der Vliet, H.N. (author), Chamuleau, R.A.F.M. (author), Havekes, L.M. (author), Groen, A.K. (author), van Dijk, K.W. (author)ApoAV has been discovered recently as a novel modifier of triglyceride (TG) metabolism, but the pathways involved are currently unknown. To gain insight into the function of apoAV, adenovirus-mediated gene transfer of murine apoa5 to C57Bl/6 mice was employed. The injection of low doses of Ad-apoa5 (1-5 x 108 plaque-forming units/mouse) dose...article 2004
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Voshol, P.J. (author), Haemmerle, G. (author), Ouwens, D.M. (author), Zimmermann, R. (author), Zechner, R. (author), Teusink, B. (author), Maassen, J.A. (author), Havekes, L.M. (author), Romijn, J.A. (author)Hormone-sensitive lipase (HSL) is a major enzyme for triglyceride (TG) lipolysis in adipose tissue. In HSL-knockout mice, plasma free fatty acid and TG levels are low, associated with low liver TG content. Because a decreased hepatic insulin sensitivity has been reported to be associated with high liver TG levels, our aim was to determine...article 2003
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Proper, K.I. (author), Koning, M. (author), van der Beek, A.J. (author), Hildebrandt, V.H. (author), Bosscher, R.J. (author), van Mechelen, W. (author)Objective: To critically review the literature with respect to the effectiveness of worksite physical activity programs on physical activity, physical fitness, and health. Data Sources: A search for relevant English-written papers published between 1980 and 2000 was conducted using MEDLINE, EMBASE, Sportdiscus, CINAHL, and Psychlit. The key...article 2003
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Visser, B. (author), de Looze, M.P. (author), Veeger, D. (author), Douwes, M. (author), Groenesteijn, L. (author), de Korte, E. (author), van Dieën, J.H. (author), TNO Preventie en Gezondheid (author)High precision demands in manual tasks can be expected to cause more selective use of a part of the muscular synergy involved. To test this expectation, load sharing of the index finger and middle finger was investigated during a pinching task. Myoelectric activation of lower arm and neck-shoulder muscles was measured to see if overall level of...article 2003
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Gaubius Instituut TNO (author), Goudriaan, J.R. (author), Dahlmans, V.E.H. (author), Teusink, B. (author), Ouwens, D.M. (author), Febbraio, M. (author), Maassen, J.A. (author), Romijn, J.A. (author), Havekes, L.M. (author), Voshol, P.J. (author)CD36 (fatty acid translocase) is involved in high-affinity peripheral fatty acid uptake. Mice lacking CD36 exhibit increased plasma free fatty acid and triglyceride (TG) levels and decreased glucose levels. Studies in spontaneous hypertensive rats lacking functional CD36 link CD36 to the insulin-resistance syndrome. To clarify the relationship...article 2003
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TNO Preventie en Gezondheid (author), Verkerke, G.J. (author), Lemmink, K.A.P.M. (author), Slagers, A.J. (author), Westhoff, M.H. (author), van Riet, G.A.J. (author), Rakhorst, G. (author)The mechanical performance, repeatability and comfort of the Quadrisotester, which assesses isometric knee extensor muscle strength, were examined. Twenty healthy subjects and 20 patients treated for unilateral anterior ligamenta cruciata insufficiency were tested. Intra-rater repeatability was determined by the testing and retesting of subjects...article 2003
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Delleman, N.J. (author), Berndsen, M.B. (author), TNO Technische Menskunde (author)At a VDU workstation professional touch-typing operators worked at eight different combined adjustments of visual target height and chair backrest inclination. Working posture, workers' perceptions and work performance were measured. Two conclusions were drawn. First, in order to minimize the load on the musculoskeletal system for touch-typing...article 2002
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