Searched for: subject:"Mucosal%5C+immunity"
(1 - 9 of 9)
document
Minihane, A.M. (author), Vinoy, S. (author), Russell, W.R. (author), Baka, A. (author), Roche, H.M. (author), Tuohy, K.M. (author), Teeling, J.L. (author), Blaak, E.E. (author), Fenech, M. (author), Vauzour, D. (author), McArdle, H.J. (author), Kremer, B.H.A. (author), Sterkman, L. (author), Vafeiadou, K. (author), Benedetti, M.M. (author), Williams, C.M. (author), Calder, P.C. (author)
The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's...
article 2015
document
Zaura, E. (author), Nicu, E.A. (author), Krom, B.P. (author), Keijser, B.J. (author)
The oral microbiota survives daily physical and chemical perturbations from the intake of food and personal hygiene measures, resulting in a long-term stable microbiome. Biological properties that confer stability in the microbiome are important for the prevention of dysbiosis-a microbial shift toward a disease, e.g., periodontitis or caries....
article 2014
document
Vandebriel, R. (author), Callant Cransveld, C. (author), Crommelin, D. (author), Diamant, Z. (author), Glazenburg, B. (author), Joos, G. (author), Kuper, F. (author), Natsch, A. (author), Nijkamp, F. (author), Noteborn, H. (author), Pieters, R. (author), Roberts, D. (author), Roggen, E. (author), Rorije, E. (author), Seed, M. (author), Sewald, K. (author), van den Heuvel, R. (author), van Engelen, J. (author), Verstraelen, S. (author), van Loveren, H. (author)
Respiratory sensitization provides a case study for a new approach to chemical safety evaluation, as the prevalence of respiratory sensitization has increased considerably over the last decades, but animal and/or human experimental/predictive models are not currently available. Therefore, the goal of a working group was to design a road map to...
article 2011
document
End, C. (author), Bikker, F.J. (author), Renner, M. (author), Bergmann, G. (author), Lyer, S. (author), Blaich, S. (author), Hudler, M. (author), Helmke, B. (author), Gassler, N. (author), Autschbach, F. (author), Ligtenberg, A.J.M. (author), Benner, A. (author), Holmskov, U. (author), Schirmacher, P. (author), Nieuw Amerongen, A.V. (author), Rosenstiel, P. (author), Sina, C. (author), Franke, A. (author), Hafner, M. (author), Kioschis, P. (author), Schreiber, S. (author), Poustka, A. (author), Mollenhauer, J. (author)
Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS-induced TLR4-mediated NF-kappaB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the molecular basis of its function...
article 2009
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Kuper, C.F. (author), Arts, J.H.E. (author), Feron, V.J. (author), TNO Voeding (author)
The mucosal membranes form a weak mechanical barrier, but they are provided with an extensive specific and non-specific defence system. Antigenic stimulation of the mucosal immune system of the oronasal passages induces specific, local immune responses, and activates immune components of mucosae elsewhere as well as the systemic immune system....
article 2003
document
Kruisselbrink, A. (author), Heijne Den Bak-Glashouwer, M.J. (author), Havenith, C.E.G. (author), Thole, J.E.R. (author), Janssen, R. (author)
Recent evidence suggests that chronic exposure to lactobacilli, which are part of the normal intestinal flora, inhibits the development of allergic disorders. Allergy is mediated by Th2 cells, which produce high levels of IL4 and IL5, and suppressive effects of lactic acid bacteria on the development of allergy have been attributed to their Th1...
article 2001
document
Thole, J.E.R. (author), van Dalen, P.J. (author), Havenith, C.E.G. (author), Pouwels, P.H. (author), Seegers, J.F.M.L. (author), Tielen, F.D. (author), van der Zee, M.D. (author), Zegers, N.D. (author), Shaw, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
By expression of foreign antigens in attenuated strains derived from bacterial pathogens and in non-pathogenic commensal bacteria, recombinant vaccines are being developed that aim to stimulate mucosal immunity. Recent advances in the pathogenesis and molecular biology of these bacteria have allowed rational development of new and improved...
article 2000
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Maassen, C.B.M. (author), van Holten-Neelen, C. (author), Balk, F. (author), den Bak-Glashouwer, M.-J.H. (author), Leer, R.J. (author), Laman, J.D. (author), Boersma, W.J.A. (author), Claassen, E. (author)
Different Lactobacillus strains are frequently used in consumer food products. In addition, recombinant lactobacilli which contain novel expression vectors can now be used in immunotherapeutic applications such as oral vaccination strategies and in T cell tolerance induction approaches for autoimmune disease. Both for food and clinical...
article 2000
document
Bruder, M.C. (author), Spanhaak, S. (author), Bruijntjes, J.P. (author), Michielsen, C.P.P.C. (author), Vos, J.G. (author), Kuper, C.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In order to study the intestinal mucosal immune cells, with emphasis on single T lymphocytcs, an inventory was made of single and organized lymphocytes in the epithelium and lamina propria of the small intestines of untreated Wistar, Fischer 344, and Lewis rats. The single and organized lymphocytes were examined microscopically. In addition, the...
article 1999
Searched for: subject:"Mucosal%5C+immunity"
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